Prospective Study to Compare Endometrial Cytology and Transvaginal Ultrasonography for Identification of Endometrial Malignancies

Tsuda, Hiroshi; Kawabata, Masami; Yamamoto, Kumio; Inoue, Takeshi; Umesaki, Naohiko

doi:10.1006/gyno.1997.4699

Cited by 35 publications

(18 citation statements)

References 12 publications

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“…endometrial thickness or progesterone challenge test). The 15 remaining studies had been performed in nine different countries. Thirteen studies were published in English, one in Portuguese and one in Italian.…”

Section: Resultsmentioning

confidence: 99%

Capacity of endometrial thickness measurement to diagnose endometrial carcinoma in asymptomatic postmenopausal women: a systematic review and meta‐analysis

Breijer¹,

Peeters

Opmeer

et al. 2012

Ultrasound in Obstet & Gyne

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Section: Resultsmentioning

confidence: 99%

Capacity of endometrial thickness measurement to diagnose endometrial carcinoma in asymptomatic postmenopausal women: a systematic review and meta‐analysis

Breijer¹,

Peeters

Opmeer

et al. 2012

Ultrasound in Obstet & Gyne

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“…In addition, this cytological testing can be used in premenopausal women who tend to exhibit false-positive abnormalities on ultrasonography scans and CA-125 assays. Moreover, endometrial cytological smears are inexpensive, well tolerated by patients, and easily performed by gynaecologists in clinical settings (Ferenczy and Gelfand, 1984; Byrne, 1990; Tsuda et al , 1997). Finally, this testing can detect endometrial carcinomas, which sometimes develop in women with breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Several case reports have shown that endometrial cytological tests developed to screen endometrial cancer (Ferenczy and Gelfand, 1984; Byrne, 1990) can detect intraepithelial and microinvasive fallopian tube carcinomas (Ikarashi et al , 1995; Luzzatto et al , 1996; Minato et al , 1998; Gocho et al , 2009, Maeda et al , 2010). In Japan, endometrial cancer screening using such cytological tests is widely performed for women at risk of the disease (Tsuda et al , 1997), including breast cancer patients treated with tamoxifen (Gocho et al , 2009; Otsuka et al , 2010), and women who request the screening. In the present study, we examined the data of patients with epithelial ovarian, fallopian tube, and primary peritoneal cancer to evaluate the role of endometrial cytological testing in detecting HGSC, particularly for screening setting.…”

mentioning

confidence: 99%

Early detection of ovarian and fallopian tube cancer by examination of cytological samples from the endometrial cavity

2013

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Background:Accumulating evidence suggests that many ovarian high-grade serous carcinomas (HGSCs) originate in the fallopian tube. Malignant cells shed by tubal lesions can be detected by examination of cytological samples from the endometrial cavity (endometrial cytological testing). To evaluate the use of this method for detecting HGSC, we examined epithelial ovarian, fallopian tube, and primary peritoneal cancer patients.Methods:Endometrial cytological testing was performed for endometrial cancer screening in asymptomatic women and for pre-treatment evaluation in symptomatic suspected ovarian, tubal, and peritoneal cancer patients.Results:Of the 122 ovarian, tubal, and peritoneal cancer patients, malignant cells were identified in 5 patients who did not show detectable abnormalities on imaging studies. Cervicovaginal cytology was positive in only one of these five patients. Four patients were asymptomatic and one was symptomatic. Three asymptomatic patients had early-stage HGSCs, and the other asymptomatic patient had positive peritoneal cytology findings but no detectable tumour. HGSC patients were significantly more likely to have positive findings on endometrial cytology than patients with other histological types (23% vs 6%, P=0.02).Conclusion:Endometrial cytological testing can detect early-stage ovarian, tubal, and peritoneal HGSCs without detectable pelvic masses and may be useful for ovarian cancer screening.

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“…In previous studies, like that of Tsuda et al [14], the endometrial carcinoma detected on Pap smears was almost entirely symptomatic; only 6% (1/16) had no symptoms. Compared to our detected cases, 11% (4/36) were asymptomatic, and 25% (1/4) of these were premenopausal.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

et al. 2015

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Objective: The presence of degenerative endometrial debris and abnormal endometrial cells is considered to be the hint for endometrial pathology. The purpose of this study was to evaluate the efficacy of Papanicolaou (Pap) smears in detecting endometrial cancers. Study Design: There were 146 cases of endometrial cancer diagnosed at our institute in 2000-2002 and 271 in 2010-2012. Among them, 57 and 95 relevant reports of Pap smears 6 months prior to the histology diagnosis were retrieved for this study, respectively. In the first time period, new criteria for detecting endometrial lesions had not yet been incorporated into routine screening. Results: Twenty cases (21%) of adenocarcinoma, 12 (13%) of atypical glandular cells, 4 (4%) of endometrial debris and 59 (62%) negative reports were found among the more recent 95 relevant Pap smears. The overall efficacy of the Pap smear for detecting endometrial malignancy was 38%, higher than 10 years previously (30%). Conclusion: Although the Pap smear was originally designed to screen cervical lesions, more effective detection of endometrial lesions could be achieved by adding new criteria to the routine screening.

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Prospective Study to Compare Endometrial Cytology and Transvaginal Ultrasonography for Identification of Endometrial Malignancies

Cited by 35 publications

References 12 publications

Capacity of endometrial thickness measurement to diagnose endometrial carcinoma in asymptomatic postmenopausal women: a systematic review and meta‐analysis

Capacity of endometrial thickness measurement to diagnose endometrial carcinoma in asymptomatic postmenopausal women: a systematic review and meta‐analysis

Early detection of ovarian and fallopian tube cancer by examination of cytological samples from the endometrial cavity

The Diagnostic Value of Routine Papanicolaou Smears for Detecting Endometrial Cancers: An Update

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