Prospects of ‘Omics Based Molecular Approaches in Colorectal Cancer Diagnosis and Treatment in the Developing World: A Case Study in Cape Town, South Africa

Adeola, Henry Ademola; Goosen, Ryan; Goldberg, P. J. P.; JonathanBlackburn,

doi:10.5772/57485

Cited by 1 publication

(3 citation statements)

References 150 publications

(153 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proteomics domain deals with the detection of the complete peptide and protein complement produced in an organism, tissue, or a cell and can be, in theory, more specifically linked to phenotypic modifications related to the pathogenesis of a certain disease. Proteomic studies may describe the functional situation of protein activities, protein-protein as well as proteinligand interactions (54). Unlike transcriptomics, proteomics methods take the post-transcription, translation, and posttranslational changes of polypeptides into account (55).…”

Section: Cancer Proteomicsmentioning

confidence: 99%

“…Metabolomics is the new omics technique used for the investigation of the presence and the abundance of metabolites (low weight biomolecules) in body fluids and cells (54). Urine, tissue, and serum are the most common specimens compatible with metabolomics analysis.…”

Section: Cancer Metabolomicsmentioning

confidence: 99%

“…Urine, tissue, and serum are the most common specimens compatible with metabolomics analysis. Through genomics and proteomics, the metabolome changes according to the individual's physiological and pathological condition and the detection of particular metabolites provide a potentially useful insight towards pathogenetic disease mechanisms (54). Metabolomic research is currently the prevailing approach for early detection and precise medicine and it may also provide information from a metabolic point of view regarding the development of cancers (42).…”

Section: Cancer Metabolomicsmentioning

confidence: 99%

See 2 more Smart Citations

Cancer Omics in Africa: Present and Prospects

et al. 2020

View full text Add to dashboard Cite

During the last century, cancer biology has been arguably one of the most investigated research ﬁelds. To gain deeper insight into cancer mechanisms, scientists have been attempting to integrate multi omics data in cancer research. Cancer genomics, transcriptomics, metabolomics, proteomics, and metagenomics are the main multi omics strategies used currently in the diagnosis, prognosis, treatment, and biomarker discovery in cancer. In this review, we describe the use of different multi omics strategies in cancer research in the African continent and discuss the main challenges facing the implementation of these approaches in African countries such as the lack of training programs in bioinformatics in general and omics strategies in particular and suggest paths to address deficiencies. As a way forward, we advocate for the establishment of an “African Cancer Genomics Consortium” to promote intracontinental collaborative projects and enhance engagement in research activities that address indigenous aspects for cancer precision medicine.

show abstract

Section: Cancer Proteomicsmentioning

confidence: 99%

Section: Cancer Metabolomicsmentioning

confidence: 99%