Prostacyclin and thromboxane in diabetic children

Käär, M.‐L.; Kääpä, Pietari; Viinikka, Lasse; Ylikorkala, Olavi

doi:10.1016/0262-1746(83)90045-8

Cited by 7 publications

(1 citation statement)

References 26 publications

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“…Therefore patients with varicose veins were studied, and moreover, veins with small varicosities are sometimes accepted as better vascular conduits than prosthetic material knowing that the presence varicose veins is a risk factor for development of thrombosis [8][9][10], Another control group would have been patients undergoing lower limb amputation, but in the present age group, they have similar risk factors as the group studied, Prostacyclin release from the vessel wall in diabetics is poorly investigated and studies on prostacyclin release into the blood stream show contradictory results. The basal release of prostacyclin in diabetics is not lower than in normal healthy volunteers when determined as the blood level of 6-keto-PGF~,, or their urinary metabolites [11,12]. During exercise, healthy individuals increase their urinary output of 2, 3 dinor 6-keto-PGF1= [13].…”

Section: Discussionmentioning

confidence: 94%

Prostacyclin release from the human saphenous vein in diabetics is lower than in nondiabetics

Brunkwall

Bergqvist

1992

World j. surg.

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The balance between prostacyclin and thromboxane has been suggested to be of great importance for the maintenance of patency in veins. In order to investigate prostacyclin and thromboxane release, segments from the human saphenous veins were investigated in 53 patients. Twenty-seven patients (10 males, 17 females) underwent surgery for varicose veins. Twenty-six patients (14 nondiabetics, 12 diabetics) underwent surgery for lower limb ischemia (rest pain or gangrene) with use of the saphenous vein as arterial conduit. Vein segments were gently excised and perfused ex vivo for five 15 minute periods, with a balanced salt solution and determination of the stable degradation products 6-keto-PGF1 alpha and TxB2. Saphenous veins from patients with varicose veins had an initial prostacyclin release of 61 +/- 13 pg/mm2/15 min declining to 4 +/- 1 pg/mm2/15 min after 60 min (p < 0.001) and increasing after addition to arachidonic acid to 37 +/- 7 pg/mm2/15 min (p < 0.001). Segments from nondiabetic patients with lower limb ischemia did not differ from those of varicectomy patients, but diabetic segments had a significantly lower prostacyclin release than both these groups, 34 +/- 11 pg/mm2/15 min, 1 +/- 1 pg/mm2/15 min, and 7 +/- 5 pg/mm2/15 min, respectively (p < 0.05). The addition of arachidonic acid failed to increase the prostacyclin release in diabetics. Three patients from each group were studied regarding thromboxane release and there was almost no detectable thromboxane in any group. These findings suggest that diabetics have a lowered prostacyclin release from the saphenous vein and that the deficiency is at the cyclo-oxygenase level.(ABSTRACT TRUNCATED AT 250 WORDS)

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