Prostaglandin (PTG) E and F receptors in the porcine corpus luteum; effect of tumor necrosis factor-α

Chang, Jing; Frandsen, S.; D’Annibale-Tolhurst, M.; Palumbo, N.; Gadsby, John E.

doi:10.1016/j.anireprosci.2018.05.017

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…2e, f). Approximately 37% of the DEgenes in the Uni-S vs Mul-S group and 41% in the Uni-L vs Mul-L group were reported to be associated with mammalian reproduction, such as TNFAIP6, MMP9, INSL3, LEPR, 3BHSD, LHCGR, ARL4C, CD36, CYP11A1, AMDHD1, SPOCK2, AMDHD1, MFAP5, CCL21, PTGFR, and SERPINA5 [23,[47][48][49][50][51][52][53][54][55][56][57][58][59][60]. Of these genes, TNFAIP6, CYP11A1, CD36, PTGFR, and SER-PINA5 were found to be associated with the ovulation rate.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of mRNAs and miRNAs in the ovarian follicles of uniparous and multiple goats at estrus phase

Zou

Zhao

et al. 2020

BMC Genomics

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Background: Fertility is an important economic trait in the production of meat goat, and follicular development plays an important role in fertility. Although many mRNAs and microRNAs (miRNAs) have been found to play critical roles in ovarian biological processes, the interaction between mRNAs and miRNAs in follicular development is not yet completely understood. In addition, less attention has been given to the study of single follicle (dominant or atretic follicle) in goats. This study aimed to identify mRNAs, miRNAs, and signaling pathways as well as their interaction networks in the ovarian follicles (large follicles and small follicles) of uniparous and multiple Chuanzhong black goats at estrus phase using RNAsequencing (RNA-seq) technique. Results: The results showed that there was a significant difference in the number of large follicles between uniparous and multiple goats (P < 0.05), but no difference in the number of small follicles was observed (P > 0.05). For the small follicles of uniparous and multiple goats at estrus phase, 289 differentially expressed mRNAs (DEmRNAs) and 16 DEmiRNAs were identified; and for the large follicles, 195 DEmRNAs and 7 DEmiRNAs were identified. The functional enrichment analysis showed that DE genes in small follicles were significantly enriched in ovarian steroidogenesis and steroid hormone biosynthesis, while in large follicles were significantly enriched in ABC transporters and steroid hormone biosynthesis. The results of quantitative real-time polymerase chain reaction were consistent with those of RNA-seq. Analysis of the mRNA-miRNA interaction network suggested that CD36 (miR-122, miR-200a, miR-141), TNFAIP6 (miR-141, miR-200a, miR-182), CYP11A1 (miR-122), SERPINA5 (miR-1, miR-206, miR-133a-3p, miR-133b), and PTGFR (miR-182, miR-122) might be related to fertility, but requires further research on follicular somatic cells. Conclusions: This study was used for the first time to reveal the DEmRNAs and DEmiRNAs as well as their interaction in the follicles of uniparous and multiple goats at estrus phase using RNA-seq technology. Our findings provide new clues to uncover the molecular mechanisms and signaling networks of goat reproduction that could be potentially used to increase ovulation rate and kidding rate in goat.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of mRNAs and miRNAs in the ovarian follicles of uniparous and multiple goats at estrus phase

Zou

Zhao

et al. 2020

BMC Genomics

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“…In the ovary, macrophages are the most abundant type of immune cells and play important roles in maintaining ovarian vascular integrity . Similarly, there are many infiltrated macrophages in the developing CL in cows, pigs and humans . As research has progressed, the role of macrophages has been clarified in inflammatory angiogenesis in the CL.…”

Section: Introductionmentioning

confidence: 99%

“…Clearly, this phenomenon is beneficial to the formation of vasculature in the CL. Additionally, macrophages are the predominant source of tumor necrosis factor alpha (TNFα) in the CL of cows, pigs and human, and TNFα is the critical inflammatory factor in regulation of luteal angiogenesis. First, TNFα can increase the level of vascular endothelial growth factor (VEGF, the main regulator of angiogenesis) and the number of its receptor in the early and middle equine luteal phases .…”

Section: Introductionmentioning

confidence: 99%

Inflammation and angiogenesis in the corpus luteum

Wang

et al. 2019

J of Obstet and Gynaecol

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Angiogenesis is a very important process that helps establish and maintain the normal structure and function of the corpus luteum (CL). Early luteal development can be considered a kind of physiological injury with an inflammatory response; therefore, the inflammatory response may play an important role in the luteal angiogenesis. The inflammatory response is companied by activated leukocytes and their mediators. For luteal tissue, numerous activated leukocytes such as macrophages, neutrophils and eosinophils are present in the early luteal phase and are widely involved in neovascularization. The objective of this review is to describe the role of the inflammatory factors in the angiogenesis and to discuss their mechanism. Knowledge of action and mechanism of these inflammatory factors on angiogenic activity will be beneficial for the understanding of luteal function.

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Progesterone inhibits cytokine/TNF-α production by porcine CL macrophages via the genomic progesterone receptor

Gadsby

Frandsen

Chang

et al. 2020

Domestic Animal Endocrinology

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Prostaglandin (PTG) E and F receptors in the porcine corpus luteum; effect of tumor necrosis factor-α

Cited by 5 publications

References 44 publications

Comprehensive analysis of mRNAs and miRNAs in the ovarian follicles of uniparous and multiple goats at estrus phase

Comprehensive analysis of mRNAs and miRNAs in the ovarian follicles of uniparous and multiple goats at estrus phase

Inflammation and angiogenesis in the corpus luteum

Progesterone inhibits cytokine/TNF-α production by porcine CL macrophages via the genomic progesterone receptor

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