Prostaglandins and the Lung

Mathé, Aleksander A.

doi:10.1007/978-1-4615-8055-3_7

Cited by 11 publications

(4 citation statements)

References 194 publications

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“…An infusion of this rate increases the concentration of PGE2 in the renal arterial plasma by only 25 pg/ml. The lung can also synthesize PGE2 (Mathe, 1977) and only a very low rate of release would be required to have a significant effect on renal function under these conditions. Other studies have not documented such sensitivity of the kidney to PGE2, although effects on renal function have previously been demonstrated during intra-renal infusions of 20 ng PGEJ/min (Vander, 1968).…”

Section: Resultsmentioning

confidence: 99%

A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E₂ AND I₂ ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS

1981

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SUMMARYProstaglandin E2 (PGE2) and prostaglandin I2 (PGI2) were infused into the renal artery ofeither sodium-loaded or sodium-depleted dogs. Systemic blood pressure was decreased and arterial plasma renin concentration increased in the sodium-loaded dogs by infusion of PGI2 (1200 ng/min). Both compounds increased renal blood flow but PGE2 had a much more potent effect than PGI2 on increasing urine flow and sodium excretion. In the sodium-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions ofPGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min). Both compounds stimulated urine flow and renal blood flow but PGE2 induced a much larger increase in sodium excretion than PGI2. PGI2 exerts its actions on renal function by inducing vasodilatation whereas PGE2 also has a direct action on tubular function.

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Section: Resultsmentioning

confidence: 99%

A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E₂ AND I₂ ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS

1981

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“…0007-1188/79/020197-08 $01.00 consequences on lung function (Mathe, 1977;Rose & Kot, 1977). When released into the bloodstream prostaglandins may also affect the systemic circulation (Malik & McGiff, 1976).…”

Section: Introductionmentioning

confidence: 99%

“…If pulmonary hypertension and/or oedema stimulate prostaglandin synthesis in lung tissue this may have important physiological and pathophysiological 1 Present address: Hormone and Isotope Laboratory, Aker Hospital, Oslo 5 Norway. 0007-1188/79/020197-08 $01.00 consequences on lung function (Mathe, 1977;Rose & Kot, 1977). When released into the bloodstream prostaglandins may also affect the systemic circulation (Malik & McGiff, 1976).…”

Section: Introductionmentioning

confidence: 99%

Lack of Release of Prostaglandins From Isolated Per-Fused Lungs During Pulmonary Hypertension and Oedema

Scott

Vaage

1979

British Journal of Pharmacology

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1 The effects on pulmonary prostaglandin synthesis of pulmonary hypertension and oedema have been studied. 2 Seventeen isolated lungs of rabbit, cat and guinea-pig were perfused with plasma, whole blood or Krebs Ringer solution in a recirculating system. 3 The venous effluent from the lungs superfused (10 ml/min) a series of smooth muscle tissues sensitive to prostaglandins and thromboxane A2; these were: rat stomach strip, rat colon, chick rectum and rabbit aorta. 4 Left atrial pressure was increased by between 10 and 30 mmHg for periods of 3 to 59 minutes. Gross alveolar oedema eventually developed in all experiments. 5 Neither pulmonary hypertension nor subsequent oedema caused release of prostaglandins into the venous effluent.

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“…F series prostaglandins (PGs) are widely distributed in various mammalian organs and exhibit a variety of biological activities including contraction of smooth muscles in the uterus (Embrey and Morrison 1968;Karim et al 1968) and pulmonary arteries (Hyman 1969;Mathè 1977). PGF 2 (PGF 2α or 9α, 11β-PGF 2 ) is synthesized from PGD 2 , PGE 2 , or PGH 2 .…”

Section: Introductionmentioning

confidence: 99%

Identification of prostaglandin F-producing cells in the liver

Suzuki-Yamamoto

Yokoi

Tsuruo

et al. 1999

Histochemistry and Cell Biology

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Prostaglandin (PG) F synthase forms PGF(2alpha) and 9alpha, 11beta-PGF2 from PGH2 and PGD2, respectively. PGH2 is synthesized from arachidonic acid by cyclooxygenase (COX) and then metabolized to various PGs and thromboxane by specific enzymes. PGD2 is synthesized from PGH2 by PGD synthase. To identify PGF2-producing cells in the rat liver, the occurrence and localization of PGF synthase and COX were studied with immunochemical and immunohistochemical techniques using anti-liver-type PGF synthase and anti-COX antibodies. In Western blot analyses, positive bands of liver-type PGF synthase and constitutive COX-1 were observed at positions approximately 37 kDa and 70-72 kDa, respectively. However, inducible COX-2 was not detected. In the immunohistochemical study, PGF synthase was present in the cytoplasm of the sinusoidal endothelial cells. COX-1 was present on the membranes of the nucleus and endoplasmic reticulum of the endothelial cells and Kupffer cells. Double immunostaining for PGF synthase and COX-1 showed that both enzymes were present in the same endothelial cells. These results suggest that the main site of PGF2 synthesis in the liver is the sinusoidal endothelial cell.

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Prostaglandins and the Lung

Cited by 11 publications

References 194 publications

A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E₂ AND I₂ ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS

A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E₂ AND I₂ ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS

Lack of Release of Prostaglandins From Isolated Per-Fused Lungs During Pulmonary Hypertension and Oedema

Identification of prostaglandin F-producing cells in the liver

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Prostaglandins and the Lung

Cited by 11 publications

References 194 publications

A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E2 AND I2 ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS

A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E2 AND I2 ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS

Lack of Release of Prostaglandins From Isolated Per-Fused Lungs During Pulmonary Hypertension and Oedema

Identification of prostaglandin F-producing cells in the liver

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A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E₂ AND I₂ ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS

A COMPARISON OF THE EFFECTS OF PROSTAGLANDINS E₂ AND I₂ ON RENAL FUNCTION AND RENIN RELEASE IN SALT‐LOADED AND SALT‐DEPLETED ANAESTHETIZED DOGS