Prostaglandins Modulate Arterial Cholesteryl Ester Metabolism

Hajjar, David P.

doi:10.1159/000469481

Cited by 13 publications

(3 citation statements)

References 16 publications

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“…It has been reported that prostaglandins modulate arterial cholesteryl-ester metabolism by stimulating the enzyme cholesteryl-hydrolase (44). Therefore, an increased prostacyclin production in the HDL-treated group might also account for the observed antiatherogenic effect.…”

Section: Discussionmentioning

confidence: 95%

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

Badimón¹,

Badimón²,

Fuster³

1990

J. Clin. Invest.

726

365

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The effects of homologous plasma HDL and VHDL fractions on established atherosclerotic lesions were studied in cholesterol-fed rabbits. Atherosclerosis was induced by feeding the animals a 0.5% cholesterol-rich diet for 60 d (group 1). Another group of animals were maintained on the same diet for 90 d (group 2). A third group was also fed the same diet for 90 d but received 50 mg HDL-VHDL protein per wk (isolated from normolipemic rabbit plasma) during the last 30 d (group 3). Aortic atherosclerotic involvement at the completion of the study was 34±4% in group 1, 38.8±5% in group 2, and 17.8±4% in group 3 (P < 0.005). Aortic lipid deposition was also significantly reduced in group 3 compared with group 1 (studied at only 60 d) and group 2. This is the first in vivo, prospective evidence of the antiatherogenic effect of HDL-VHDL against preexisting atherosclerosis. Our results showed that HDL plasma fractions were able to induce regression of established aortic fatty streaks and lipid deposits. Our results suggest that it may be possible not only to inhibit progression but even to reduce established atherosclerotic lesions by HDL administration. (J. Clin. Invest. 1990.

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Section: Discussionmentioning

confidence: 95%

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

Badimón¹,

Badimón²,

Fuster³

1990

J. Clin. Invest.

726

365

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“…It is possible that the fats affect the prostaglandin metabolism in the arterial wall. 26 It has been observed that feeding olive oils to rabbits results in a higher arterial PGI 2 production than feeding corn oil. 27 The effect of these oils may be caused by their fatty acid content but may also be due to one or more of the many other constituents in the oils.…”

Section: Downloaded Frommentioning

confidence: 99%

Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

et al. 1988

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Two groups of 18 rabbits were fed Isocalorlc, cholesterol-enriched diets for 8 weeks. The diet for one group was supplemented with 5% corn oil. The concentration of cholesterol in plasma was determined weekly and the amount of cholesterol In the diet was adjusted Individually so that each rabbit had a mean plasma cholesterol concentration of about 45 mM during the experimental period. The aortic cholesterol concentrations were 122 ± 29 and 193 ± 38 (mean ± SEM) /xmol/g protein for the cornoil group and the control group, respectively (p<0.05). In a similar experiment, each of 36 rabbits was given a mean plasma cholesterol level of about 20 mM over a period of 12 weeks. One-third of the rabbits received 10% to 15% corn oil, another third 10% to 15% olive oil, while the last third served as a control group. The aortic cholesterol concentrations were 98 ± 25, 57 ± 9, and 131 ± 32 ^mol/g protein, respectively. The value for the olive-oil group was significantly (p<0.01) lower than the value for the control group. The trlglycerlde concentrations and the distributions of cholesterol between HDL, LDL, and VLDL In plasma showed no significant differences between the plant-oil groups and their control groups. This suggests that plant oils have a direct effect on the aortic cholesterol metabolism. (Arteriosclerosis 8:281-287, May/June 1988)

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“…17) [105]. On the basis of the investigations discussed here, this local deficiency [104,105] in prostacyclin could result in the vascular tissue no longer being capable of effectively counteracting further deposition of cholesterol esters, so that the atheromatosis would advance rapidly. The cAMP in its turn stimulates the breakdown of the cholesterol esters by activating cholesterol ester hydrolase.…”

Section: Antiatherogenic Actionmentioning

confidence: 91%

Prostacyclin and Hypertension

Bönner¹,

Rahn²

1990

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Prostaglandins Modulate Arterial Cholesteryl Ester Metabolism

Cited by 13 publications

References 16 publications

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit.

Antiatherogenic effect of olive and corn oils in cholesterol-fed rabbits with the same plasma cholesterol levels.

Prostacyclin and Hypertension

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