Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle

Huang, Na; Liu, Bo; Dong, Zhong; Mao, Wei; Zhang, Nan; Li, Changyou; Cao, Jinshan

doi:10.1016/j.prostaglandins.2015.08.002

Cited by 19 publications

(5 citation statements)

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“…This idea is further corroborated by the finding that FeSP neurons express ptger4b in an ovarian estrogen-dependent manner, as PGE 2 signaling has been implicated in female receptivity across vertebrate phyla. Similar induction of EP4 expression by estrogens has been reported in the smooth muscle of the ewe cervix and bovine oviduct 25 , 26 . Additionally, in female rats, PGE 2 affects the excitability of preoptic gonadotropin-releasing hormone 1 (GnRH1) neurons via EP4, depending on the presence of estrogens 27 , suggesting that the expression of EP4 in these neurons is dependent on estrogens, as is the case in FeSP neurons.…”

Section: Discussionsupporting

confidence: 81%

Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

et al. 2022

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In vertebrates, female receptivity to male courtship is highly dependent on ovarian secretion of estrogens and prostaglandins. We recently identified female-specific neurons in the medaka (Oryzias latipes) preoptic area that express Npba, a neuropeptide mediating female sexual receptivity, in response to ovarian estrogens. Here we show by transcriptomic analysis that these neurons express a multitude of neuropeptides, in addition to Npba, in an ovarian-dependent manner, and we thus termed them female-specific, sex steroid-responsive peptidergic (FeSP) neurons. Our results further revealed that FeSP neurons express a prostaglandin E2 receptor gene, ptger4b, in an ovarian estrogen-dependent manner. Behavioral and physiological examination of ptger4b-deficient female medaka found that they exhibit increased sexual receptivity while retaining normal ovarian function and that their FeSP neurons have reduced firing activity and impaired neuropeptide release. Collectively, this work provides evidence that prostaglandin E2/Ptger4b signaling mediates the estrogenic regulation of FeSP neuron activity and female sexual receptivity.

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Section: Discussionsupporting

confidence: 81%

Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

et al. 2022

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“…Transport of gametes and embryos through the oviduct is directly and/or indirectly regulated by E 2 and P 4 . For example, these hormones regulate the spatiotemporal expression of the prostaglandin receptors for PGE 2 and PGF 2a , which control the activities of secreted ECs and smooth muscle for optimal embryo transport through the oviduct (34). As E 2 promotes muscular contraction and P 4 stimulates relaxation (35), the loss of Egr1 in the oviduct may affect smooth muscle activity.…”

Section: Discussionmentioning

confidence: 99%

Estrogen induces EGR1 to fine‐tune its actions on uterine epithelium by controlling PR signaling for successful embryo implantation

Kim

Yoon

et al. 2018

FASEB j.

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The harmonized actions of ovarian E and progesterone (P) regulate the proliferation and differentiation of uterine cells in a spatiotemporal manner. Imbalances between these hormones often lead to infertility and gynecologic diseases. Whereas numerous factors that are involved in P signaling have been identified, few local factors that mediate E actions in the uterus have been revealed. Here, we demonstrate that estrogen induces the transcription factor, early growth response 1 ( Egr1), to fine-tune its actions in uterine epithelial cells (ECs) that are responsible for uterine receptivity for embryo implantation. In the presence of exogenous gonadotrophins, ovulation, fertilization, and embryonic development normally occur in Egr1 mice, but these animals experience the complete failure of embryo implantation with reduced artificial decidualization. Although serum levels of E and P were comparable between Egr1 and Egr1 mice on d 4 of pregnancy, aberrantly reduced levels of progesterone receptor in Egr1 uterine ECs caused enhanced E activity and impaired P response. Ultrastructural analyses revealed that Egr1 ECs are not fully able to provide proper uterine receptivity. Uterine mRNA landscapes in Egr1 mice revealed that EGR1 controls the expression of a subset of E-regulated genes. In addition, P signaling was unable to modulate estrogen actions, including those that are involved in cell-cycle progression, in ECs that were deficient in EGR1. Furthermore, primary coculture of Egr1 ECs with Egr1 stromal cells, and vice versa, supported the notion that Egr1 is required to modulate E actions on ECs to prepare the uterine environment for embryo implantation. In contrast to its role in ECs, loss of Egr1 in stroma significantly reduced stromal cell proliferation. Collectively, our results demonstrate that E induces EGR1 to streamline its actions for the preparation of uterine receptivity for embryo implantation in mice.-Kim, H.-R., Kim, Y. S., Yoon, J. A., Yang, S. C., Park, M., Seol, D.-W., Lyu, S. W., Jun, J. H., Lim, H. J., Lee, D. R., Song, H. Estrogen induces EGR1 to fine-tune its actions on uterine epithelium by controlling PR signaling for successful embryo implantation.

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“…The smooth muscle contraction in the oviduct is regulated by prostaglandins (PGs) through prostanoid receptors, which are modulated by E 2 (Spilman & Harper 1975, Ball et al 2013, Huang et al 2015. In humans, the oviductal PGs are mainly PGE and PGF produced by epithelial cells (Lindblom et al 1983).…”

Section: Smooth Muscle Contractionmentioning

confidence: 99%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

209

191

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Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental regulation, oviductal fluid composition and its role in protecting embryos and supplying nutrients. Finally, the review compares different aspects of naturally occurring fertilization and assisted reproductive technology (ART)-achieved fertilization and embryo development, giving insight into potential areas for improvement in this technology.

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Prostanoid receptors EP2, EP4, and FP are regulated by estradiol in bovine oviductal smooth muscle

Cited by 19 publications

References 50 publications

Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

Estrogen induces EGR1 to fine‐tune its actions on uterine epithelium by controlling PR signaling for successful embryo implantation

Oviduct: roles in fertilization and early embryo development

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