Prostate Cancer

Abstract

suggests the primary risk factors are obesity, age and family history. Prostate cancer is very uncommon in men younger than 45, but becomes more common with advancing age. The average age at the time of diagnosis is 70 years 1 . However, many men never know they have prostate cancer. Autopsy studies of Chinese's, German, Israeli, Jamaican, Swedish, and Ugandan men who died of other causes have found prostate cancer in 30% of men in their 50s, and in 80% of men in their 70s 2 . Men whom have first degree family members with prostate cancer appear to have doubled the risk of getting and disease compared to men without prostate cancer in the family 3 . This risk appears to be grater for men with an affected brother than for men with an affected father. Men with high blood pressure are more likely to develop prostate cancer. There is a small increased risk of prostate cancer associated with lack of exercise 4 . A 2010 study found that prostate basal cells were the most common site of origin for prostate cancers 6 . IntroductionAdenocarcinoma of prostate is the most common form of cancer in men 25% by incidence and second by 10% morality throughout the World. There is one in six lifetime probability of being diagnosed with prostate cancer in men. Prostate cancer a disease of men over 50 years. In autopsy the incidence of prostate cancer is very high 20% in 50s to 70% between 70-80 years. Prostate cancer is uncommon in Asian and occurs most frequently in blacks. Androgen play on important role in prostate cancer. Growth and survival of prostate cancer cells depends on androgen which is bound to the androgen receptor (AR) and induce the expression of progrowth and prosurvival genes. The active metabolite of testosterone (Dihydroxy Testesterone) DHT constitutes about 90% of prostatic androgens 1 . Risk FactorsUnderstanding of the different causes of prostate cancer remains research interest. Accumulative evidence from the already done research work 7(2)