Prostate cancer assessment using MR elastography of fresh prostatectomy specimens at 9.4 T

Reiter, Rolf; Majumdar, Shreyan; Kearney, Steven; Kajdacsy-Balla, André; Macias, Virgilia; Crivellaro, Simone; Caldwell, Brandon; Abern, Michael R.; Royston, Thomas J.; Klatt, Dieter

doi:10.1002/mrm.28127

Cited by 14 publications

(11 citation statements)

References 27 publications

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“…The driver was tested in prostate-mimicking gelatin phantoms to explore the imaging parameters of transurethral MRE and to determine whether they encompass the requirements for prostate cancer localization. A more recent study carried out by Reiter et al [177] investigated the limitations present in MRI, such as interobserver variability and low specificity. For this purpose, fourteen fresh prostate specimens from men were examined.…”

Section: Prostatementioning

confidence: 99%

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Rus

Faris

Torres

et al. 2020

Sensors

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The adoption of multiscale approaches by the biomechanical community has caused a major improvement in quality in the mechanical characterization of soft tissues. The recent developments in elastography techniques are enabling in vivo and non-invasive quantification of tissues’ mechanical properties. Elastic changes in a tissue are associated with a broad spectrum of pathologies, which stems from the tissue microstructure, histology and biochemistry. This knowledge is combined with research evidence to provide a powerful diagnostic range of highly prevalent pathologies, from birth and labor disorders (prematurity, induction failures, etc.), to solid tumors (e.g., prostate, cervix, breast, melanoma) and liver fibrosis, just to name a few. This review aims to elucidate the potential of viscous and nonlinear elastic parameters as conceivable diagnostic mechanical biomarkers. First, by providing an insight into the classic role of soft tissue microstructure in linear elasticity; secondly, by understanding how viscosity and nonlinearity could enhance the current diagnosis in elastography; and finally, by compounding preliminary investigations of those elastography parameters within different technologies. In conclusion, evidence of the diagnostic capability of elastic parameters beyond linear stiffness is gaining momentum as a result of the technological and imaging developments in the field of biomechanics.

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Section: Prostatementioning

confidence: 99%

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Rus

Faris

Torres

et al. 2020

Sensors

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“…One of its main applications so far has been the assessment of hepatic fibrosis 13–16 and, more recently, hepatic inflammation 17–19 . Moreover, technical advances have improved the spatial resolution and noise robustness of elastograms, allowing the examination of smaller organs such as the prostate 10,20 and pancreas 21,22 …”

mentioning

confidence: 99%

Feasibility of IntestinalMRElastography in Inflammatory Bowel Disease

Reiter

Loch

Kamphues

et al. 2021

Magnetic Resonance Imaging

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Background While MR enterography allows detection of inflammatory bowel disease (IBD), the findings continue to be of limited use in guiding treatment—medication vs. surgery. Purpose To test the feasibility of MR elastography of the gut in healthy volunteers and IBD patients. Study Type Prospective pilot. Population Forty subjects (healthy volunteers: n = 20, 37 ± 14 years, 10 women; IBD patients: n = 20 (ulcerative colitis n = 9, Crohn's disease n = 11), 41 ± 15 years, 11 women). Field Strength/Sequence Multifrequency MR elastography using a single‐shot spin‐echo echo planar imaging sequence at 1.5 T with drive frequencies of 40, 50, 60, and 70 Hz. Assessment Maps of shear‐wave speed (SWS, in m/s) and loss angle (φ, in rad), representing stiffness and solid–fluid behavior, respectively, were generated using tomoelastography data processing. Histopathological analysis of surgical specimens was used as reference standard in patients. Statistical Tests Unpaired t‐test, one‐way analysis of variance followed by Tukey post hoc analysis, Pearson's correlation coefficient and area under the receiver operating characteristic curve (AUC) with 95%‐confidence interval (CI). Significance level of 5%. Results MR elastography was feasible in all 40 subjects (100% technical success rate). SWS and φ were significantly increased in IBD by 21% and 20% (IBD: 1.45 ± 0.14 m/s and 0.78 ± 0.12 rad; healthy volunteers: 1.20 ± 0.14 m/s and 0.65 ± 0.06 rad), whereas no significant differences were found between ulcerative colitis and Crohn's disease (P = 0.74 and 0.90, respectively). In a preliminary assessment, a high diagnostic accuracy in detecting IBD was suggested by an AUC of 0.90 (CI: 0.81–0.96) for SWS and 0.84 (CI: 0.71–0.95) for φ. Data Conclusion In this pilot study, our results demonstrated the feasibility of MR elastography of the gut and showed an excellent diagnostic performance in predicting IBD. Evidence Level 1 Technical Efficacy Stage 1

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“…Taking the curl of the Helmholtz equation increases the differentiation order but physically isolates the shear component of interest. This approach has become prominent when the Helmholtz equation is employed to retrieve storage and loss moduli [172,187,189,190,198,199,232,247,248]. To improve resolution and stabilize the direct inversion of the monofrequency Helmholtz equation, a multi-frequency approach named MDEV (multi-frequency dual elasto visco inversion) was introduced [200].…”

Section: Direct Methodsmentioning

confidence: 99%

Viscoelasticity Imaging of Biological Tissues and Single Cells Using Shear Wave Propagation

Flé

Bhatt

et al. 2021

Front. Phys.

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Changes in biomechanical properties of biological soft tissues are often associated with physiological dysfunctions. Since biological soft tissues are hydrated, viscoelasticity is likely suitable to represent its solid-like behavior using elasticity and fluid-like behavior using viscosity. Shear wave elastography is a non-invasive imaging technology invented for clinical applications that has shown promise to characterize various tissue viscoelasticity. It is based on measuring and analyzing velocities and attenuations of propagated shear waves. In this review, principles and technical developments of shear wave elastography for viscoelasticity characterization from organ to cellular levels are presented, and different imaging modalities used to track shear wave propagation are described. At a macroscopic scale, techniques for inducing shear waves using an external mechanical vibration, an acoustic radiation pressure or a Lorentz force are reviewed along with imaging approaches proposed to track shear wave propagation, namely ultrasound, magnetic resonance, optical, and photoacoustic means. Then, approaches for theoretical modeling and tracking of shear waves are detailed. Following it, some examples of applications to characterize the viscoelasticity of various organs are given. At a microscopic scale, a novel cellular shear wave elastography method using an external vibration and optical microscopy is illustrated. Finally, current limitations and future directions in shear wave elastography are presented.

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Prostate cancer assessment using MR elastography of fresh prostatectomy specimens at 9.4 T

Cited by 14 publications

References 27 publications

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?

Feasibility of IntestinalMRElastography in Inflammatory Bowel Disease

Viscoelasticity Imaging of Biological Tissues and Single Cells Using Shear Wave Propagation

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