Prostate cancer in dogs: Comparative and clinical aspects

LeRoy, Bruce E.; Northrup, Nicole C.

doi:10.1016/j.tvjl.2008.07.012

Cited by 186 publications

(254 citation statements)

References 95 publications

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“…Prostatic carcinomas occur in sexually intact and neutered dogs and pulmonary and bone metastases are common [6]. Some Authors reported that the risk to be associated to pulmonary and bone metastases increase in castrated dogs [4]. The frequency of prostatic carcinoma in dog is low and the prevalence reported from necroscopy studies ranges between 0.2% and 0.6% [6].…”

Section: Discussionmentioning

confidence: 99%

“…The early stage of human prostate cancer is an intra-epithelial neoplasia (PIN) in dog the relationship between PIN and prostate carninoma is unknown. Canine prostate neoplasia does not express androgen receptor and the castration may be associated with an increased risk of prostate adenocarcinoma [4,10]. Castration modified the stromal component of the gland from primarily actin-positive smooth muscle cells to vimentin-positive mesenchymal cells.…”

Section: Discussionmentioning

confidence: 99%

“…In old men the frequency of prostate cancer at autopsy has been reported to exceed 40% [3]. Dogs are the only large mammals other than humans with a significant incidence of spontaneous prostate cancer [4].…”

Section: Introductionmentioning

confidence: 99%

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Canine Prostate Carcinoma: Four Clinical Cases in Sexually Intact and Neutered Dogs

Bigliardi¹,

Bresciani²,

Cantoni³

et al. 2012

OJU

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Prostate cancer is one of the most important malignancies in men. In old men the frequency of prostate cancer at necroscopy has been reported to exceed 40%. Dogs are the only large mammals other than humans with a significant incidence of spontaneous prostate cancer. Adenocarcinoma, transitional cell carcinoma and undifferentiated carcinoma are the most common histological type but the precise cell of origin in dog is not known. The incidence of prostatic carcinoma in dogs is low (0.2% -0.6%). Prostatic carcinomas occur in sexually intact and neutered dogs and the risk increase in castrated dogs associated to pulmonary and bone metastases. The castration does not initiate the development of prostatic carcinoma in dog but does favour tumour progression. In men the early stage detection of prostate cancer can offer various therapies as radical prostatectomy, radial therapy, thermal ablation, anti-androgen therapy, chemotherapy. In dogs the diagnosis is often in advanced stage of the cancer and the survival time for dogs with prostate cancer is poor. The median time reported is 30 days after diagnosis. In this study we reported three cases of prostatic carcinoma in intact sexually dogs and one in a neutered dog. The sexually intact subjects were older (mean age = 10.5 years) and they had prostatic adenocarcinoma (PCA). The interval between castration and onset of prostatic problems was 3 years. All the dogs showed dysuria, macroscopic hematuria, dyschezia and ataxia. All dogs have been euthanized in order to relieve pain and suffering.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Canine Prostate Carcinoma: Four Clinical Cases in Sexually Intact and Neutered Dogs

Bigliardi¹,

Bresciani²,

Cantoni³

et al. 2012

OJU

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show abstract

“…Acredita-se que cães com ocorrência natural de câncer prostático são modelos relevantes para estudos da doença em humanos e terapias em cães podem beneficiar tanto estes quanto os homens. (LEROY et al, 2007;LEROY & NORTHRUP, 2009).…”

Section: Doenças Prostáticasunclassified

“…O septo mediano na face dorsal divide a glândula em dois lobos, um direito e um esquerdo. Cada lobo é dividido em lóbulos, que consistem em uma numerosa composição de glândulas tubuloalveolares (EVANS & CHRISTENSEN, 1993;BARSANTI & FINCO, 1995;LEROY & NORTHRUP, 2009).…”

Section: Introductionunclassified