Prostate Cancer Incidence in Guadeloupe, a French Caribbean Archipelago

Mallick, S.; Blanchet, Pascal; Multigner, Luc

doi:10.1016/j.eururo.2005.02.020

Cited by 45 publications

(29 citation statements)

References 7 publications

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“…In addition, there is evidence that African-Americans are more likely to be diagnosed at a younger age and have more aggressive forms of prostate cancer than European-American men [39]. High incidence rates have also been reported among men in the French Caribbean archipelago of Guadeloupe, where 90% of the residents are of African descent [40] This contrasts with the lower rates of prostate cancer diagnosed among Asian men [25,41]. While the exact reasons for these racial differences are unclear [39], they could include genetic susceptibility to prostate cancer, different levels of androgenic activity within the prostate gland [25, 39, 41 -43], in addition to differences in diet, socioeconomic status, environmental and lifestyle factors [39].…”

Section: Racial Variationmentioning

confidence: 95%

International epidemiology of prostate cancer: Geographical distribution and secular trends

Baade

Youlden

Krnjacki

2009

Molecular Nutrition Food Res

378

314

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This review outlines current international patterns in prostate cancer incidence and mortality rates and survival, including recent trends and a discussion of the possible impact of prostate-specific antigen (PSA) testing on the observed data. Internationally, prostate cancer is the second most common cancer diagnosed among men (behind lung cancer), and is the sixth most common cause of cancer death among men. Prostate cancer is particularly prevalent in developed countries such as the United States and the Scandinavian countries, with about a six-fold difference between high-incidence and low-incidence countries. Interpretation of trends in incidence and survival are complicated by the increasing impact of PSA testing, particularly in more developed countries. As Western influences become more pronounced in less developed countries, prostate cancer incidence rates in those countries are tending to increase, even though the prevalence of PSA testing is relatively low. Larger proportions of younger men are being diagnosed with prostate cancer and living longer following diagnosis of prostate cancer, which has many implications for health systems. Decreasing mortality rates are becoming widespread among more developed countries, although it is not clear whether this is due to earlier diagnosis (PSA testing), improved treatment, or some combination of these or other factors.

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Section: Racial Variationmentioning

confidence: 95%

International epidemiology of prostate cancer: Geographical distribution and secular trends

Baade

Youlden

Krnjacki

2009

Molecular Nutrition Food Res

378

314

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“…Moreover, its worldwide increasing incidence, unknown etiology and an observed high prevalence among farmers [10,11] and in areas of high pesticides use called for investigating the impact of environmental and occupational exposures [12].…”

Section: Introductionmentioning

confidence: 99%

Organochlorine pesticides and prostate cancer, Is there an association? A meta-analysis of epidemiological evidence

Lewis-Mikhael

Olmedo-Requena

Martínez-Ruiz

et al. 2015

Cancer Causes Control

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“…(11). In the absence of a cancer registry for Guadeloupe, we considered data published by urologists of the University Hospital of Pointe-a-Pitre in Guadeloupe (9). Although the evolution of incidence rates for prostate cancer in Guadeloupe tends to be similar to the one in Martinique, we could not use published data from Guadeloupe for comparison, because these data were established without using the standardized procedures and criteria set up by the French National Cancer Registry (12).…”

Section: Introductionmentioning

confidence: 99%

“…Prostate cancer has become very frequent in Martinique and Guadeloupe and these two places are presently regarded as having one of the highest world age standardized incidence rates (9,10). Martinique and Guadeloupe are two tropical islands in the French West Indies.…”

Section: Introductionmentioning

confidence: 99%

Prostate cancer as an environmental disease: An ecological study in the French Caribbean islands, Martinique and Guadeloupe

Belpomme¹

2009

Int J Oncol

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Abstract. Using a transdisciplinary methodological approach we have conducted a multifactorial analysis in Martinique and Guadeloupe in order to elucidate the aetiology of prostate cancer. In 2002, world age standardized rates of prostate cancer were 152 new cases per 100,000 person-years in the two islands; one of the highest worldwide rates and much higher than those reported for other Caribbean islands and metropolitan France. Using a linear regression analysis, we found that the growth curves of incidence rates for Martinique and metropolitan France have been significantly diverging since 1983. That these curves are not parallel suggests that although a Caribbean genetic susceptibility factor may be involved in carcinogenesis, this factor cannot per se account for the observed growing incidence. On the basis of mapping analysis of soil pollution, we further showed that water contamination by pesticides originates from banana plantations. Moreover, we have established retrospectively that general population subjects investigated in 1972 in Martinique for the presence of organochlorinated pesticides in their adipose tissue had been contaminated by extremely high levels of DDT, DDE, ·, ß and ÁHCH, aldrin and dieldrin. Our study leads to the conclusion that the growing incidence of prostate cancer cannot be related either to a modification of ethnographic factors nor to a change in lifestyle and therefore suggests that environmental factors such as the intensive and prolonged exposure to carcinogenic, mutagenic and reproductive toxin pesticides may cause prostate cancer.

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Prostate Cancer Incidence in Guadeloupe, a French Caribbean Archipelago

Cited by 45 publications

References 7 publications

International epidemiology of prostate cancer: Geographical distribution and secular trends

International epidemiology of prostate cancer: Geographical distribution and secular trends

Organochlorine pesticides and prostate cancer, Is there an association? A meta-analysis of epidemiological evidence

Prostate cancer as an environmental disease: An ecological study in the French Caribbean islands, Martinique and Guadeloupe

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