Prostate Cancer Screening

Prostate Cancer Screening in the Midst of Controversy: Canadian Men’s Knowledge, Beliefs, Utilization, and Future Intentions

“…3,4 Fredrick D. Ashbury, PhD, 5,6 Donald C. Iverson, PhD, 5,7 Neill A. Iscoe, MD, MSc, FRCPC 1,8 should undergo pretest counselling and should give informed consent. 3,4,10,15,[26][27][28] Yet, some U.S. groups recommend annual PSA screening from age 50. 9 Although most groups maintain that there is insufficient evidence to recommend DRE screening, several U.S. and Canadian groups recommend annual DRE from age 40.…”

“…6,[8][9][10] Both tests have low sensitivity (DRE: 40%-77%; PSA: 43%-79%) and specificity (DRE: 50%-97%; PSA: 59%-90%) and a high false positive rate (DRE: 5%-11%; PSA: 8%-26%). 3,4,7,8,[10][11][12][13][14][15][16][17] PSA testing finds many early tumours. 5,7 Prostate cancer, however, may grow slowly or remain in a latent stage.…”

“…19 Determining which early cancers will become life-threatening is currently impossible. 3,15,20 Also, evidence is limited regarding whether treating early prostate cancer reduces mortality. 15,[21][22][23][24][25] Moreover, treatment side effects include incontinence, impotence, and bowel injury.…”

“…3,15,20 Also, evidence is limited regarding whether treating early prostate cancer reduces mortality. 15,[21][22][23][24][25] Moreover, treatment side effects include incontinence, impotence, and bowel injury. 3,22,26 Prostate cancer incidence rises with age.…”

Rapid Bispecific Antibodies Based Homogeneous Immunoassay for Detection of Prostate-Specific Antigen (PSA)

“…Whole blood analysis of prostate-specific antigen spotted on a solid support is patented by Savajani [7]. Prostate-specific antigen (PSA), an important tumor associated marker [8,9] is produced by the prostatic epithelium.…”