2020
DOI: 10.1016/j.jchromb.2020.122298
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Prostate cancer screening using chemometric processing of GC–MS profiles obtained in the headspace above urine samples

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Cited by 19 publications
(12 citation statements)
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“…Production of VOCs by the human body differs greatly by individual, since VOCs are influenced by genetic background, environmental factors, and medical history, such as a comorbidity [14]. However, VOCs have been associated with many cancer types [15][16][17][18][19][20][21][22][23][24][25][26][27], and it has been suggested that they can be used as alternative cancer screening markers. Canine cancer detection, as well as the recent Caenorhabditis elegans cancer detection method, are believed to be based on these cancer-related VOCs [18,28].…”
Section: Discussionmentioning
confidence: 99%
“…Production of VOCs by the human body differs greatly by individual, since VOCs are influenced by genetic background, environmental factors, and medical history, such as a comorbidity [14]. However, VOCs have been associated with many cancer types [15][16][17][18][19][20][21][22][23][24][25][26][27], and it has been suggested that they can be used as alternative cancer screening markers. Canine cancer detection, as well as the recent Caenorhabditis elegans cancer detection method, are believed to be based on these cancer-related VOCs [18,28].…”
Section: Discussionmentioning
confidence: 99%
“…Raja et al 26 conducted a metabolomics study based on 1 H NMR for cancer targeting and metabolic engineering, using traditional chemometric methods such as principal component analysis (PC) and partial least-squares discriminant analysis (PLS-DA) to examine metabolic differences. Deev et al 27 developed prostate cancer screening methodologies using chemometric processing of GC−MS profiles obtained in the headspace above urine samples, where they applied the PC for exploratory data analysis, the methods k-nearest neighbors (KNN), and the PLS-DA to make the models allowing attribution of a urine sample to the particular class. Drivelos et al 28 developed methodologies for identifying the geographical origin and botanical type honey authentication through elemental metabolomics via chemometrics.…”
Section: ■ Introductionmentioning
confidence: 99%
“…The most used method to enhance compounds to headspace in urine is based on salt addition, which produces a variation in the equilibrium where neutral organic compounds move to the gas phase [ 28 ]. Studies that tested the salt addition found an increase in the number of compounds extracted in the headspace[ 27 , 29 32 ]. Nevertheless, salt saturation can be contra-productive due to opposite effects: a decrease in the number of compounds [ 30 , 33 ], and an increase in the degraded compounds [ 34 ].…”
Section: Urine Pretreatmentmentioning
confidence: 99%