Prostate cancers in men under the age of 50: about a series in Togo, Sub-Saharan Africa

Djiwa, Toukilnan; Kpatcha, Tchilabalo Matchonna; Padja, Essodina; Napo‐Koura, Gado; Darré, Tchin

doi:10.1186/s12885-022-10425-6

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…These results are similar to those of Tengue et al who described symptoms of the lower urinary tract in 89.2% [9]. Darré et al had also found functional urinary signs in 37.93% [12]. This high frequency of functional urinary disorders could be explained by the fact that they constitute a nuisance in daily life forcing the patient to consult.…”

Section: Data Related To Late Diagnosis Of Prostate Cancersupporting

confidence: 90%

“…Histologically, these were adenocarcinomas in 99% and squamous cell carcinoma in 1%. These were only adenocarcinomas in the series by Darré et al [12]. A predominance of prostate adenocarcinomas was also reported by Ndoye et al in 97.7% of cases [16].…”

Section: Data Related To Late Diagnosis Of Prostate Cancersupporting

confidence: 63%

“…A family history of prostate cancer was noted in 17.7% of patients. Darré et al found a family history of prostate cancer in 41.38% [12].…”

Section: Epidemiological Datamentioning

confidence: 99%

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Factors associated with late diagnosis of prostate cancer in Togo, Sub-Saharan Africa

Darré,

Djiwa,

Padja

et al. 2024

Preprint

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Background : Prostate cancer represents a real public health issue in countries with limited resources and is often diagnosed at late stages. The aim of the study was to determine the factors associated with late diagnosis of prostate cancer in Togo. Methods: This was a cross-sectional study with a descriptive and analytical, relating to cases of prostate cancer, diagnosed in the Urology department and histologically confirmed at the Pathological Anatomy and Cytology Laboratory of the Lomé; from April 4, 2022 to April 28, 2023, in Togo. Results: A total, 102 cases of prostate cancer were recorded. The average age was 67.79 ± 8.5 years. The mean PSA level was 521.3933±1060 ng/ml. Histologically, it was acinar adenocarcinoma in 99.02%. All patients in our study were diagnosed at the late stage with 31.37% pT3NxMx stage and 68.63% pT4NxMx stage of the pTNM classification. It was Gleason score 9 in 31 patients (30.39%). After multivariate analysis, two factors were associated with late diagnosis of prostate cancer : diagnostic error (p-value = 0.032; ORC = 1.30; 95% CI [1.10-24.9]); taking a second opinion (p-value = 0.0170; ORa = 2.62; 95% CI [2.01-4.7]). However, factors involving easy access to the health system before prostate cancer diagnosis appear to be major protective factors for diagnosis at an advanced stage of disease. Conclusion: The diagnosis error and the taking of a second opinion are the factors on which it will be necessary to act to make an early diagnosis of prostate cancer in our context.

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Section: Data Related To Late Diagnosis Of Prostate Cancersupporting

confidence: 90%

Section: Data Related To Late Diagnosis Of Prostate Cancersupporting

confidence: 63%

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Factors associated with late diagnosis of prostate cancer in Togo, Sub-Saharan Africa

Darré,

Djiwa,

Padja

et al. 2024

Preprint

Self Cite

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Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old from a single tertiary referral centre: a propensity score matched analysis

Pang,

Fallara,

Hemat

et al. 2024

Int J Impot Res

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Penile cancer (PeCa) is rare, and the oncological outcomes in younger men are unclear. We aimed to analyse and compare oncological outcomes of men age ≤50 years (y) and >50 years with PeCa. A retrospective analysis of men ≤50 y with penile squamous cell carcinoma managed at a tertiary centre was performed. A propensity score matched cohort of men >50 y was identified for comparison. Matching was according to tumour, nodal stage and the types of primary surgery. Overall survival (OS), disease-specific survival (DSS), recurrence-free survival (RFS), and metastasis-free survivals (MFS) were estimated using Kaplan–Meier plots and compared using log-rank tests. Between 2005–2020, 100 men ≤50 y (median (IQR) age, 46 y (40–49)) were identified and matched with 100 men >50 y (median (IQR) age, 65 y (59–73)). 10, 24, 32, 34 men age ≤50 y were diagnosed in 2005–2007, 2008–2012, 2013–2016 and 2017–2020 respectively. Median (IQR) follow-up was 53.5 (18–96) months. OS at 2 years: ≤50 y, 86%>50 y, 80.6%; 5 years: ≤50 y, 78.1%, >50 y, 63.1%; 10 years: ≤50 y, 72.3%, >50 y, 45.6% (p = 0.01). DSS at 2 years: ≤50 y, 87.2%>50 y, 87.8%; 5 years: ≤50 y, 80.9%>50 y, 78.2%; 10 years: ≤50 y, 78%, >50 y, 70.9% (p = 0.74). RFS was 93.1% in the ≤50 y group (vs. >50 y, 96.5%) at 2 year, and 90% (vs. >50 y, 88.5%) at 5 years, p = 0.81. Within the ≤50 y group, 2 years and 5 years MFS was 93% (vs. >50 y, 96.5%), and 89.5% (vs. >50 y, 92.7%) respectively, (p = 0.40). There were no statistical significance in DFS, RFS and MFS in men age ≤50 y and >50 y. PeCa in younger patients is fatal, public awareness and patient education are crucial for early detection and management.

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Prostate cancers in men under the age of 50: about a series in Togo, Sub-Saharan Africa

Cited by 2 publications

References 21 publications

Factors associated with late diagnosis of prostate cancer in Togo, Sub-Saharan Africa

Factors associated with late diagnosis of prostate cancer in Togo, Sub-Saharan Africa

Long-term outcomes of penile squamous cell carcinoma in men age ≤50 years old compared with men >50 years old from a single tertiary referral centre: a propensity score matched analysis

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