Prostate-specific antigen and prostate-specific antigen density cutoff points among Indonesian population suspected for prostate cancer

Shahab, Ahmad Anies; Soebadi, Doddy M.; Djatisoesanto, Wahjoe; Hardjowijoto, Sunaryo; Soetojo,; Hakim, Lukman

doi:10.12954/pi.12003

Cited by 23 publications

(23 citation statements)

References 20 publications

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“…Another study in Surabaya was carried out including 404 patients who underwent prostate biopsy with indication of PSA >10 ng/ml or PSAD >0.15 if the PSA was between 4 and 10 ng/ml; with these criteria, they found 11.1% prostate cancer. To increase the positive biopsy rate, this study suggests using a PSA cutoff point of 14.55 ng/ml in patients using catheter due to retention (23). In 1994, trans-rectal ultrasound (TRUS) guided prostate biopsy was introduced in Indonesia and becomes the standard method for prostate cancer diagnosis.…”

Section: Prostate Cancermentioning

confidence: 99%

Urologic cancer in Indonesia

Umbas

Safriadi

Mochtar

et al. 2015

Jpn. J. Clin. Oncol.

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Non-communicable diseases, including cancer, start to become more common in Indonesia. According to the government statement, incidence of malignant diseases increased annually up to 8% in the last decade and these diseases become the seventh leading cause of death in Indonesia. On the basis of the latest Globocan report on cancer incidence in Indonesia, prostate cancer ranks sixth; followed by bladder (12th) and kidney (18th). More than half of patients with kidney cancer are diagnosed in the advanced stage. Besides renal cell carcinoma, there are significant number of people affected with squamous cell and transitional cell carcinoma because of kidney stones. Radical nephrectomy or cytoreductive nephrectomy was the primary treatment, mostly done as an open procedure. Transitional cell carcinoma is the commonest histology type in bladder cancer cases followed by squamous cell carcinoma, which almost always related to bladder stones. Unfortunately, >70% of our cases were diagnosed with muscle invasive bladder cancer, and ∼60% of these patients refused further radical treatment. Incidence of prostate cancer is increasing rapidly and it becomes the third most common cancer in men. However, most of our patients are diagnosed in the advanced stage. Radical prostatectomy or external beam radiotherapy is the treatment of choice in localized disease. Nearly 40% of the elderly patients are treated with primary androgen deprivation therapy. Therefore, it requires more research by the Indonesian urologists and other healthcare providers to diagnose these cancers in earlier stage as well as community education for prevention.

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Section: Prostate Cancermentioning

confidence: 99%

Urologic cancer in Indonesia

Umbas

Safriadi

Mochtar

et al. 2015

Jpn. J. Clin. Oncol.

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“…Significant research efforts are ongoing to identify the optimal PSA threshold to recommend a prostate biopsy in an asymptomatic patient ( 5 , 8 ). Catalona et al reported this PSA level or higher was appropriate as the PSA cut-off value for the screening of PCa.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Recently, various strategies were introduced to improve the sensitivity and specificity of the PSA ( 5 ). In these studies, prostate volume, PSA level and age were clinically significant predictors of positive biopsy findings ( 5 , 6 ). Patel et al ( 7 ) developed a novel formula that incorporates age, prostate volume, race and PSA level into a single score for prostate cancer detection.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey

Üçer

Yücetaş²,

Çelen³

et al. 2015

Int. braz j urol.

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Objectives:To evaluate PSA-age volume (AV) scores in predicting positive prostate biopsy findings in Turkey.Materials and Methods:PSA-AV was calculated by multiplying the patient's age by the prostate volume and dividing it by the PSA level. Sensitivities and specificities of the PSA-AV were assessed by retrospective analysis of findings from 4,717 prostate biopsies.Results:The population's average age was 63.71±7.63 years, the mean PSA level was 9.73±17.01ng/mL, the mean prostate volume was 44.46±23.88 cm3. Of the 4,717 prostate biopsies, 1,171 biopsy specimens (24.8%) were positive for prostate cancer. A PSA-AV score of 700 had a sensitivity and specificity of 95% and 15%, respectively. These values were similar to the sensitivity and specificity for a PSA cut-off of 4ng/mL (94% and 13%, respectively). Although the sensitivity of a PSA-AV cut-off of 700 in patients over 60 years was similar to the PSA cut-off of 4ng/mL and the age-adjusted PSA, in patients <60 years, its sensitivity was higher. While the sensitivities of a PSA-AV cut-off of 700 in patients with low prostate volume was higher than a PSA cut-off of 4ng/ mL, the sensitivities of both methods with moderate prostate volumes were similar.Conclusions:Considering all the biopsies, the sensitivity and specificity of a PSA-AV of 700 for predicting positive biopsy findings were similar to a PSA of 4ng/mL. We suggest the PSA-AV cut-off of 700 should only be used in patients younger than 60 with low prostate volumes (<20cm3).

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“…1,2 Statistics suggest that its incidence and the death rate are rapidly increasing, despite improved detection rates. This may be due to rapid increases in the population age and changes in dietary habits.…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome in patients with prostate cancer undergoing intermittent androgen-deprivation therapy

Rezaei¹,

Rezaei²,

Ghoreifi

et al. 2016

CUAJ

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Introduction: The presence of metabolic syndrome in men with prostate cancer (PCa) undergoing androgen-deprivation therapy (ADT), especially intermittent type, has not been completely evaluated. The aim of this study is to evaluate metabolic syndrome in men with PCa undergoing intermittent ADT. Methods: In this longitudinal study, we studied the prevalence of metabolic syndrome and its components in 190 patients who were undergoing intermittent ADT. The metabolic syndrome was defined according to the Adult Treatment Panel III criteria. All metabolic parameters, including lipid profile, blood glucose, blood pressures, and waist circumferences of the patients were measured six and 12 months after treatment. Results: Mean age of the patients was 67.5 ± 6.74 years. The incidence of metabolic syndrome after six and 12 months was 6.8% and 14.7%, respectively. Analysis of various components of the metabolic syndrome revealed that patients had significantly higher overall prevalence of hyperglycemia, abdominal obesity, and hypertriglyceridemia in their six-and 12-month followups, but blood pressure has not been changed in the same period except for diastolic blood pressure after six months. Conclusions: Although there was an increased risk of metabolic syndrome in patients receiving intermittent ADT, it was lower than other studies that treated the same patients with continuous ADT. Also it seems that intermittent ADT has less metabolic complications than continuous ADT and could be used as a safe alternative in patients with advanced and metastatic PCa.

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Prostate-specific antigen and prostate-specific antigen density cutoff points among Indonesian population suspected for prostate cancer

Cited by 23 publications

References 20 publications

Urologic cancer in Indonesia

Urologic cancer in Indonesia

Assessment of PSA-Age volume score in predicting positive prostate biopsy findings in Turkey

Metabolic syndrome in patients with prostate cancer undergoing intermittent androgen-deprivation therapy

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