Prostate-Specific Antigen Kinetics After Hypofractionated Stereotactic Body Radiation Therapy Boost and Whole-Pelvic Radiation Therapy for Intermediate- and High-Risk Prostate Cancer

Abstract

Cox regression analysis. PSA doubling time and nadir before increase were prognostically significant in case of PSA recurrence (10-year overall survival of 71% vs. 41% with PSA doubling time >6 months vs. <6 months; P Z 0.01; 63% vs. 46% with a nadir <1ng/mL vs. >1ng/mL; P Z 0.02). Conclusion: Rising PSA levels particularly in the second year following RT after reaching a nadir <1ng/mL indicates a prognostically favorable PSA bounce. A short PSA doubling time and a higher nadir are associated with an adverse prognosis in case of a PSA recurrence.