Prostate‐specific antigen recurrence and mortality after conventional dose radiation therapy in select men with low‐risk prostate cancer

Abstract

Underlying the importance of research on the biology of aging is the fact that many nations face the demographic reality of a rapidly aging populace and the looming healthcare challenges that it brings. This reality is a result of aging itself being the most significant risk factor for a range of the most prevalent diseases, including many cancers, cardiovascular disease, and diabetes. Accordingly, interventions are sorely needed that would be able to delay or prevent diseases and disorders associated with the aging process and thereby increase the period of time that aging individuals are in good health (the health‐span). Caloric restriction (CR) has emerged as a model of major interest as it is widely agreed that CR is the most potent environmental intervention that delays the onset of aging and extends life span in diverse experimental organisms. A better understanding of the mechanisms by which CR delays aging will reveal new insights into the aging process and the underlying causes of disease vulnerability with age. These novel insights will allow the development of novel treatments and preventive measures for age‐associated diseases and disorders. Am. J. Hum. Biol. 2012. © 2012 Wiley Periodicals, Inc.

Influence of Trigger PSA and PSA Kinetics on 11C-Choline PET/CT Detection Rate in Patients with Biochemical Relapse After Radical Prostatectomy

“…Moreover, it is known that rapid change in PSA kinetics, either before or after treatment, is an indicator of poor prognosis after surgery or radiation therapy (27)(28)(29). Therefore, it is possible that 11 C-choline PET/CT is more likely to be positive not only in patients with high levels of trigger PSA but also in patients with faster changes in PSA kinetics.…”

The normal post-surgical anatomy of the male pelvis following radical prostatectomy as assessed by magnetic resonance imaging

“…Radical prostatectomy is the most frequently used treatment for carcinoma confined to the prostate [1][2][3]. It involves removal of the entire prostate gland and the seminal vesicles, with the formation of an anastomosis between the membranous urethra and the bladder.…”

Role of Kinetic Performance of Psa in Selection of the Patients for Conduction of ¹¹c-Choline Pet/Ct Aimed to Reveal Local Recurrences of Prostate Cancer

“…Для решения этой проблемы за последние годы стало активно развиваться изучение кинетических характеристик ПСА. По результатам ряда исследований кинетические характеристики ПСА зарекомендовали себя при прогнозировании возникновения рецидивов и выживаемости при РПЖ [2,8,[13][14][15]. К кинетическим характеристикам ПСА относятся скорость нарастания ПСА и время удвоения ПСА.…”

“…11 C-холин-позитронно-эмиссионная томография (ПЭТ) уже продемонстрировала свою эффективность при выявлении рецидивов РПЖ у пациентов после РТ, но была клинически менее точной при обследовании пациентов после РП [1, 5,12,16,17]. ПСА и его кинетические характеристики рассматриваются как прогностически значимые параметры при отборе пациентов для проведения 11 C-холин-ПЭТ с целью выявления местных рецидивов РПЖ [2,[13][14][15].…”