2019
DOI: 10.1111/ans.15479
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Prostate‐specific membrane antigen for the surgical oncologist: interpreting expression beyond the prostate

Abstract: The use of prostate-specific membrane antigen (PSMA) radiotracer in positron emission tomography (PET) has been successfully incorporated into the clinical management of prostate cancer. However, PSMA tracer uptake is not limited to prostate cancer tissue. We reviewed studies exploring PSMA expression beyond the prostate gland using techniques of 68 Ga-PSMA PET imaging and immunohistochemistry. PSMA expression has been associated with a variety of solid tumours, and the vasculature associated with neoplastic d… Show more

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Cited by 6 publications
(8 citation statements)
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“…PSMA expression in NPCaT is more commonly associated with tumours which undergo neovascularization such as RCC, breast, glial tumours, gastrointestinal, pancreatic and lung tumours, all of which were represented in our cohort [ 24 29 ]. Further tumours reported to express PSMA not represented in our study include oral SCC, salivary ductal carcinoma, medullary thyroid carcinoma, small cell lung cancer, osteosarcoma, gynaecological malignancies, and adenoid cystic tumours [ 30 , 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…PSMA expression in NPCaT is more commonly associated with tumours which undergo neovascularization such as RCC, breast, glial tumours, gastrointestinal, pancreatic and lung tumours, all of which were represented in our cohort [ 24 29 ]. Further tumours reported to express PSMA not represented in our study include oral SCC, salivary ductal carcinoma, medullary thyroid carcinoma, small cell lung cancer, osteosarcoma, gynaecological malignancies, and adenoid cystic tumours [ 30 , 31 ].…”
Section: Discussionmentioning
confidence: 99%
“…[16] There are a number of potential reasons for this, including differing demographics, de nitions of 'major' clinical signi cance, with stricter evidence-based criteria used in our study, the use of subspecialist radiologists to exclude benign pathologies along with our exclusion of pre-existing known pathologies PSMA expression in non-prostate cancer tumors is more commonly associated with tumors which undergo neovascularization such as RCC, breast, glial tumors, gastrointestinal, pancreatic and lung tumors, all of which were represented in our cohort. [17][18][19][20][21][22] Such expression is variable but has signi cant clinical implications.…”
Section: Discussionmentioning
confidence: 99%
“…It is noteworthy that these concepts remain in the realm of research and the full clinical impact of these applications is yet to be determined. [17,26] This study bene ted from large numbers and a multicenter international database. Limitations include its retrospective design and not all patients having histopathological con rmation.…”
Section: Discussionmentioning
confidence: 99%
“…Endothelial PSMA expression appears in almost all non‐prostatic solid malignant tumours associated with neovasculature but is rare in benign endothelial tissue 3,5 . Due to this, some have raised hypotheses about the role of PSMA in neoangiogenesis and vascular growth factor regulation 6,7 .…”
Section: Figmentioning
confidence: 99%