Prostate Stereotactic Body Radiation Therapy With a Focal Simultaneous Integrated Boost: 5-Year Toxicity and Biochemical Recurrence Results From a Prospective Trial

Focal radiotherapy boost to MR-visible tumor for prostate cancer: a systematic review

“…All studies except for 2SMART described the sequences used to delineate IPLs; they utilized at least T 2 -weighted imaging (T2W). Three studies utilized at least T2W and DWI [ 10 , 12 , 14 , 17 ]. DWI generally includes generation of ADC maps, where specifically cited in one study [ 17 ] and are the primary images for most lesions according to PI-RADS radiologist guidelines [ 9 ].…”

“…Three studies utilized at least T2W and DWI [ 10 , 12 , 14 , 17 ]. DWI generally includes generation of ADC maps, where specifically cited in one study [ 17 ] and are the primary images for most lesions according to PI-RADS radiologist guidelines [ 9 ]. The FLAME trial utilized the following sequences: T2W, DWI, and DCE.…”

“…All but one study described techniques used for verification of patient setup [ 8 ]. Five studies required gold fiducial placement at simulation [ 10 , 12 , 14 – 17 ]. One study used infrared external markers [ 7 ].…”

“…Six studies treated patients using IMRT/VMAT; these studies utilized a simultaneous integrated boost approach [ 8 , 10 , 12 , 14 – 17 ]. One study treated patients with a sequential boost and utilized 3D conformal radiation therapy for the initial course followed by IMRT boost [ 7 ].…”

“…One study had separate arms that treated patients with standard fractionation and moderate hypofractionation [ 12 ]. There were three SBRT trials with two studies investigating five-fraction SBRT [ 15 , 17 ] and one trial studying two-fraction SBRT [ 16 ].…”