Prostatic Carcinoma with Concomitant Non-Hodgkin Lymphoma

Richter, S; Bechar, Leon

doi:10.1159/000280959

Cited by 11 publications

(12 citation statements)

References 3 publications

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“…We encountered three cases in our series that were T‐cell lymphoma, as well as four cases of diffuse, small noncleaved cell type, non‐Burkitt's lymphoma. Eight of our patients had coexistent prostatic adenocarcinoma, similar to two cases reported previously 36…”

Section: Discussionsupporting

confidence: 90%

Malignant lymphoma involving the prostate

Bostwick

Iczkowski

Amin

et al. 1998

Cancer

133

149

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BACKGROUND Malignant lymphoma involving the prostate is rare, and to the authors' knowledge the factors determining patient outcome have not been studied in a large series. METHODS The authors evaluated the clinical and pathologic findings in 60 cases of non‐Hodgkin's lymphoma and 2 cases of Hodgkin's lymphoma involving the prostate. A variety of clinical and histologic findings were considered as factors predictive of patient outcome. RESULTS Lymphoma tended to occur in elderly men, with a mean age at diagnosis of 62 years (range, 5‐89 years), although 6 patients were age < 40 years (ages 5, 19, 30, 32, 38, and 38 years, respectively). Clinical signs and symptoms were due to lower urinary tract obstruction. Twenty‐two patients (35%) presented with primary extranodal lymphoma of the prostate with a variety of histologic subtypes, including small lymphocytic (4 patients); follicular center cell, diffuse, small cell (2 patients); follicular center cell, Grade 1 (according to the revised European‐American classification (small cleaved) (1 patient); Grade 2 (mixed) (1 patient); diffuse large B‐cell (12 patients); and high grade B‐cell lymphoma, Burkitt‐like (2 patients). At the time of presentation, none of these patients had hepatosplenomegaly, inguinal lymphadenopathy, or an abnormal complete blood count. Thirty other patients (48%) with previously documented lymphoma at other sites developed prostatic involvement; these secondary prostatic lymphomas displayed a variety of subtypes, including small lymphocytic (8 patients, all with concomitant leukemia); follicular center cell lymphoma, diffuse, small cell (2 patients); follicular center, Grade 1 (small cell) (1 patient); follicular center, Grade 2 (1 patient); diffuse large B‐cell (11 patients); peripheral T‐cell lymphoma (2 patients); high grade B‐cell lymphoma, Burkitt‐like (1 patient); Burkitt's lymphoma (1 patient); Hodgkin's lymphoma (nodular sclerosing [1 patient] and mixed cellularity [1 patient]); and unknown (1 patient). Ten cases were not classifiable as primary or secondary lymphomas. Twenty‐five patients died of malignant lymphoma, 14 died of unknown or other causes, 18 patients were alive 12‐20 months after diagnosis (8 primary and 10 secondary tumors; 3 had persistent lymphoma; all treated since 1981), and 5 were lost to follow‐up. Lymphoma specific survival was 64% at 1 year (95% confidence interval [CI], 51‐80%), 50% at 2 years (95% CI, 36‐68%), 33% at 5 years, 33% at 10 years, and 16% at 15 years. There was no difference in median survival after diagnosis of prostatic involvement between primary and secondary lymphoma (23 months vs. 28 months, respectively) or among histologic types. CONCLUSIONS Although malignant lymphoma involving the prostate is rare, it should be considered in the differential diagnosis of lower urinary tract obstruction, particularly in patients with a previous history of lymphoma. Cancer 1998;83:732‐738. © 1998 American Cancer Society.

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Section: Discussionsupporting

confidence: 90%

Malignant lymphoma involving the prostate

Bostwick

Iczkowski

Amin

et al. 1998

Cancer

133

149

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“…Concomitance of lymphoid and urogenital malignan cies has been reported several times [1][2][3]. Interestingly, aberrations of chromosome 17, with particular involve ment of the proximal portion of the 17 short arm, are…”

Section: Discussionmentioning

confidence: 99%

“…chromosome 17 long arm [6], Worthy of note is that the 2 cases of B cell chronic lymphocytic leukemia reported by Vahdati et al [8] with the isochromosome 17q (long arm) in their cell lines underwent a prostatectomy at that time. Prostatic malignancy was not reported then [8] but it has happened that malignancy was not detected on histopathologic ex aminations [1].…”

Section: Casementioning

confidence: 99%

“…When multiple primary malignancies have a simultaneous occurrence, it is reasonable to assume that a common etiologic agent might be involved. Groset al [1] recently pointed out the concomitance of lymphomas with prostatic cancer. That prompted us to report other cases of concomitant, or better still simultaneous, occur rences of urogenital and other malignancies, and to ad vance a hypothesis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Concomitance of Urogenital with Lymphoid and Intestinal Malignancies: More Than a Coincidence

Shabtai¹,

Lask²,

Kimchi³

et al. 1985

Urol Int

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Concomitance of different primary malignant neoplasms in the same individual has been observed and explained by several possible mechanisms. For urogenital malignancies in concomitance with lymphoid or with intestinal malignancies some data indicate that common etiologic factor(s) with pleiotropic effects may be involved. Concomitance of these particular different primary malignant neoplasms must therefore be kept in mind in the evaluation of patients’ conditions.

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“…The authors found only eight such cases in a review of 62 primary and secondary prostatic lymphomas retrieved from the files of several American Institutions. Besides this review, only one previous report with two additional cases has been recorded in recent years 2 . A new case of this association is presented with special attention to the diagnostic difficulties on small core prostatic biopsies…”

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confidence: 96%