Prostatic lesions: Histopathological study in a tertiary care hospital

Bhatta, Sushama; Hirachan, Suzita

doi:10.3126/jmmihs.v4i1.21133

Cited by 5 publications

(15 citation statements)

References 10 publications

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“…Our findings are comparable with other studies done by Bhatta S et al [16] and Deshmukh et al [15] . (Table 5).…”

Section: Discussionsupporting

confidence: 93%

Histopathological study of prostatic lesions at a tertiary care hospital, Gujarat

Shaikh,

Parikh,

Parikh

et al. 2024

Int. J. Clin. Diagn. Pathol.

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Introduction: Prostatitis, benign nodular hyperplasia, and prostatic adenocarcinoma are the common diseases affecting men commonly after their fifth decade. Prostatic tumors are a very important cause of male morbidity and mortality. Aim and Objectives:The objective of this study was to observe the histopathological spectrum of prostatic lesions, to estimate the frequency of various prostatic lesions and to correlate them with demographic and clinical findings. Materials and Methods: A descriptive and observational study was conducted in the department of pathology at Narendra Modi Medical College and Sheth LG General Hospital from January 2022 to January 2024.This study was conducted on 50 prostatic specimens received from surgery department. Results: The age of the patients ranged from 43 to 91 years with peak age group of 61-70 years. Transurethral resection of prostate (TURP) was done in 21 (42%) cases, tru-cut core needle biopsy was done in 13(26%) cases and prostatectomy was done in 16 (32%) cases. Out of 50 prostatic specimens received, 44 cases were benign lesions and 6 cases showed prostatic malignancy. All 6 cases of prostatic adenocarcinoma were of acinar type. Gleason score 7 was the commonest score seen in 4 (66.66%) out of 6 cases. All cases of prostatic carcinoma had S.PSA level >10 ng/ml. In present study among all prostatic carcinoma cases, perineural invasion were reported in 3 (50%) cases. Conclusion: Histopathological examination of prostatic lesions plays an important role in diagnosis, management and prognosis of the patients. Early diagnosis and treatment help to reduce mortality and morbidity related to prostatic lesions.

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“…Our findings are comparable with other studies done by Bhatta S et al [16] and Deshmukh et al [15] . (Table 5).…”

Section: Discussionsupporting

confidence: 93%

Histopathological study of prostatic lesions at a tertiary care hospital, Gujarat

Shaikh,

Parikh,

Parikh

et al. 2024

Int. J. Clin. Diagn. Pathol.

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“…Rajani D from India reported similar findings in 2020 (1). Similar pattern of lesions was reported by different studies done by Shah, Hussain AG from Iraq, Josephine A, Neha A, Bhatta S, Yadav M (11)(12)(13)(14)(15)(16). Testosterone hormone causes the hypertrophy of the gland by binding to DHT receptors in prostate (2).…”

Section: Discussionsupporting

confidence: 57%

Histopathological Findings in Prostatic Chips and its Correlation with Prostate Specific Antigen Levels

Nadeem¹,

Rehman²,

Farooq³

et al. 2022

PJMHS

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Objectives: To determine the pattern of histological findings in prostatic chips obtained from cases of enlarged prostate gland and to correlate the findings with PSA levels. Materials and Methods: It was a cross sectional descriptive study conducted in Northwest General Hospital , Peshawar from 1st January 2018 to 23rd December 2021. A total of 500 male cases with features of enlarged prostate, frequency, urgency and dribbling with mean age of 52 ± 12.3 years (range 45 -80 years) were included in the study. The prostatic biopsy specimens were obtained and PSA levels were done in all cases. The histological specimens were subjected to microscopic examinations and findings were recorded in proforma. The findings were correlated with the PSA levels. Mean and standard deviation were used for quantitative data. Frequency and percentages were used for qualitative data Results: Out of 500 cases of enlarged prostate, benign prostate hypertrophy was seen in 375 (75%) cases. 125 cases (25%) had micro invasive carcinoma prostate . All 375 cases of benign prostate hypertrophy had prostate specific antigen levels less than 4ng. Out of 125 cases of micro invasive carcinoma, 120 (96%) had PSA levels >10ng . Sensitivity of PSA at levels of 10ng/ml for prostatic carcinoma was 96%. Conclusion: Benign prostate hypertrophy is the commonest lesion in cases of prostate pathology. PSA is useful marker to determine the presence or absence of micro invasive carcinoma in patients with prostate hypertrophy. Keywords: Benign prostate hypertrophy, micro invasive carcinoma prostate, prostate specific antigen.

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“…21 Bhatta S et al in their study found PNI in 37.5% cases. 17 In our study, lymphovascular invasion (LVI) was noted in 30% case and high Gleason's score 9 (20%). May M et al in their study stated that LVI was seen in 10.2% cases with high PSA, 79% of cases had a Gleason score of > or = 7.…”

Section: Discussionmentioning

confidence: 51%

“…Bhatta S et al stated most common grade group in their study was grade group 4 and the most predominant Gleason score was 9, which indicated poor prognosis. 17 Gleason score of 9 was seen in 3 out of 8 cases (37.5%). A study by Deshmukh BD et al found Gleason score 9 in 33.33% cases.…”

Section: Discussionmentioning

confidence: 93%

Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma

Aditi¹,

Naik²

2023

JDPO

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Benign prostatic hyperplasia (BPH) and prostate adenocarcinoma are the most common disorders affecting elderly men. The diseases are androgen-dependent and are treated by obstructing androgen receptor (AR) or their action. AR has direct relationship between the development of prostatic hyperplasia and prostatic carcinoma. Estrogens directly target prostate tissue by definite estrogen receptors (ER). The human prostate is primed with a dual system of ERs (ER-α and ER-β). Use of estrogens as hormonal agents is for suppressing prostatic tissue growth. Study aims to identify, assess and establish the significance of ER and AR as a marker in distinguishing BPH and prostatic carcinoma. A cross sectional study was conducted at a tertiary care hospital over a period of two year on 65 specimens which included 30 malignant cases and 35 benign cases. Specimens received were tru-cut biopsy, transurethral resection of prostate chips (TURP) and prostatectomy specimen for malignant cases and TURP for benign lesions. Paraffin embedded blocks was stained with H&E and IHC with ER and AR performed on representative sections and graded .the results were assessed for association with various parameters in both benign and malignant cases. Out of 30 cases of adenocarcinoma of prostate majority of specimens were needle biopsies (54%). The age of presentation was 55-84 years with mean age being 68.93 years. In cases of BPH the presenting age was 35-84 years and mean age was 63 years. Histopathological parameters assessed for malignant lesions, showed negative correlation of grade group with PNI and positive correlation with neutrophils. Higher grade showed adverse histological parameters. %PSA was <25% in malignancy. ER positivity was noted in 80% malignant and 100% benign cases with weaker positivity noted maximum in benign cases. AR positivity was noted in all cases both benign and malignant, with benign cases showing higher intensity. Hormones play a multifactorial role in the pathogenesis of BPH and prostatic carcinoma; most commonly androgen and estrogen, and can be used towards finding a better therapy.

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Prostatic lesions: Histopathological study in a tertiary care hospital

Cited by 5 publications

References 10 publications

Histopathological study of prostatic lesions at a tertiary care hospital, Gujarat

Histopathological study of prostatic lesions at a tertiary care hospital, Gujarat

Histopathological Findings in Prostatic Chips and its Correlation with Prostate Specific Antigen Levels

Immunohistochemistry analysis of estrogen receptor and androgen receptor in benign prostatic hyperplasia and prostate carcinoma

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