Prosthetic Patches Used to Close Congenital Diaphragmatic Defects Behave Well: A Long-Term Follow-Up Study

Kort, Laetitia M.O. de; Bax, Klaas N M A

doi:10.1055/s-2008-1066490

Cited by 32 publications

(34 citation statements)

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“…This may reflect the fact that men are more likely to sustain mild to moderate trauma at a younger age. Whereas our review found that 62% of the patients were female, it is reported that the prevalence among infants is equal between the sexes [36].…”

Section: Discussionmentioning

confidence: 86%

Presentation and management of Morgagni hernias in adults: a review of 298 cases

2008

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Section: Discussionmentioning

confidence: 86%

Presentation and management of Morgagni hernias in adults: a review of 298 cases

2008

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“…11,25 Surgical treatment of congenital abnormalities is often complicated by insufficient available tissue at the time of repair, resulting in the use of synthetic materials and a corresponding high morbidity rate. [26][27][28][29][30] Alternatively, broad potential for differentiation and high proliferation rates make AFSC well suited for use in regenerative medicine therapies such as engineered skeletal/cardiac muscles, tendons, heart valves, and blood vessels. 11,17,[31][32][33][34][35] This study confirms our previous work on the capacity for VEGF-mediated differentiation of c-kit + AFSC into endothelial-like cells, 14 as well as illustrates the vasculogenic and perivasculogenic potential of AFSC within a threedimensional fibrin/PEG scaffold in vitro.…”

Section: Discussionmentioning

confidence: 99%

Capillary-Like Network Formation by Human Amniotic Fluid-Derived Stem Cells Within Fibrin/Poly(Ethylene Glycol) Hydrogels

Benavides

Quinn

Pok

et al. 2015

Tissue Engineering Part A

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A major limitation in tissue engineering strategies for congenital birth defects is the inability to provide a significant source of oxygen, nutrient, and waste transport in an avascular scaffold. Successful vascularization requires a reliable method to generate vascular cells and a scaffold capable of supporting vessel formation. The broad potential for differentiation, high proliferation rates, and autologous availability for neonatal surgeries make amniotic fluid-derived stem cells (AFSC) well suited for regenerative medicine strategies. AFSC-derived endothelial cells (AFSC-EC) express key proteins and functional phenotypes associated with endothelial cells. Fibrin-based hydrogels were shown to stimulate AFSC-derived network formation in vitro but were limited by rapid degradation. Incorporation of poly(ethylene glycol) (PEG) provided mechanical stability (65% -9% weight retention vs. 0% for fibrin-only at day 14) while retaining key benefits of fibrin-based scaffolds-quick formation (10 -3 s), biocompatibility (88% -5% viability), and vasculogenic stimulation. To determine the feasibility of AFSC-derived microvasculature, we compared AFSC-EC as a vascular cell source and AFSC as a perivascular cell source to established sources of these cell types-human umbilical vein endothelial cells (HUVEC) and mesenchymal stem cells (MSC), respectively. Cocultures were seeded at a 4:1 endothelial-toperivascular cell ratio, and gels were incubated at 37°C for 2 weeks. Mechanical testing was performed using a stress-controlled rheometer (G¢ = 95 -10 Pa), and cell-seeded hydrogels were assessed based on morphology. Network formation was analyzed based on key parameters such as vessel thickness, length, and area, as well as the degree of branching. There was no statistical difference between individual cultures of AFSC-EC and HUVEC in regard to these parameters, suggesting the vasculogenic potential of AFSC-EC; however, the development of robust vessels required the presence of both an endothelial and a perivascular cell source and was seen in AFSC cocultures (70% -20% vessel length, 90% -10% vessel area, and 105% -10% vessel thickness compared to HUVEC/MSC). At a fixed seeding density, the coculture of AFSC with AFSC-EC resulted in a synergistic effect on network parameters similar to MSC (150% vessel length, 147% vessel area, 150% vessel thickness, and 155% branching). These results suggest that AFSC-EC and AFSC have significant vasculogenic and perivasculogenic potential, respectively, and are suited for in vivo evaluation.

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“…In the study by de Kort and Bax, only 1 of 30 children undergoing prosthetic patch repair of CDH experienced recurrence. However, none of the patients in that series had diaphragmatic agenesis, and most of the diaphragmatic defects were described as small or moderate [6]. Moss et al [7] reported a different experience with the GT patch.…”

Section: Discussionmentioning

confidence: 96%

“…The use of the Gore-Tex (GT) patch seems to vary among different centers and comparison of results is not clear. Some may use patches very liberally, whereas others view reconstruction with foreign material as a last resort [6][7][8]. However, there are long-term complications associated with the use of synthetic patches.…”

Section: Introductionmentioning

confidence: 97%

Congenital diaphragmatic hernia: onset of respiratory distress and size of the defect

et al. 2006

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The purpose of this study was to evaluate the outcome in neonates with congenital diaphragmatic hernia (CDH) either presenting within the first 24 h of life or diagnosed prenatally. The study was particularly focused on the time of onset of respiratory distress and on the use of the Gore-Tex (GT) patch for diaphragmatic reconstruction. Records of 104 neonates with CDH were retrospectively reviewed. The data were analyzed by ANOVA, Kruskal-Wallis test or chi (2) test as appropriate. The result showed that the overall survival rate was 73.1% (76/104). Survival of operated neonates was 91.6% (76/83). Postnatally diagnosed neonates with the onset of respiratory distress within the first minute of life survived in 67%, with the onset between 2 and 10 min survived in 89%, whilst neonates with the onset of respiratory distress after l0 min survived in 100% (P = 0.007). Birth weight, gestational age, time of onset of respiratory distress and Apgar score significantly differed between survivors and nonsurvivors. Primary closure of the diaphragmatic defect was performed in 62 patients while the GT patch was used in 21 patients. The survival of patients with a large defect treated with a GT patch was lower (76.2 vs. 96.8%, P = 0.003). There was only one case of recurrence in our series with the GT patch. Survival depends on the time of onset of respiratory distress and size of the defect, both of which correlate with the degree of pulmonary hypoplasia. The term high-risk CDH is appropriate only for children with respiratory distress within the first 10 min of life and those diagnosed prenatally. The GT patch is a suitable material for the diaphragmatic reconstruction; we suppose that the recurrence is caused by incorrect attachment of the patch to the thoracic wall.

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Prosthetic Patches Used to Close Congenital Diaphragmatic Defects Behave Well: A Long-Term Follow-Up Study

Cited by 32 publications

References 1 publication

Presentation and management of Morgagni hernias in adults: a review of 298 cases

Presentation and management of Morgagni hernias in adults: a review of 298 cases

Capillary-Like Network Formation by Human Amniotic Fluid-Derived Stem Cells Within Fibrin/Poly(Ethylene Glycol) Hydrogels

Congenital diaphragmatic hernia: onset of respiratory distress and size of the defect

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