Protection against Oxidative Damage by Dihydroflavonols in<i>Engelhardtia chrysolepis</i>

Haraguchi, Hiroyuki; Mochida, Yasutomo; Sakai, Sachiko; Masuda, Hiroto; Tamura, Yukiyoshi; Mizutani, Kenji; Tanaka, Osamu; Chou, Wen-Hua

doi:10.1271/bbb.60.945

Cited by 79 publications

(45 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 Astilbin exhibits a variety of other biological activities such as reducing total liver cholesterol concentration, 9 protecting against oxidative damage to liver mitochondria and hemolysis erytrocytes, 10 inhibiting lens aldose reductase to prevent cataract formation in diabetes, 11 enhancement of the vanadate-stimulated release of lipoprotein lipase activity, 12 and hepatoprotective effect in rats 13 and mices.…”

Section: Resultsmentioning

confidence: 99%

Toxicity of Dimorphandra mollis to Workers of Apis mellifera

Cintra

Malaspina

Petacci³

et al. 2002

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

Nesta comunicação estamos reportando as propriedades tóxicas dos extratos metanólicos das flores, pedúnculos, folhas, pecíolo e casca do tronco de Dimorphandra mollis sobre as operárias de Apis mellifera. Astilbina (3-β-O-rhamnosideo de 5,7,3',4'-tetraidroxi-2,3-diidroflavonol) isolada dos pedúnculos e flores como o seu principal componente, apresentou atividade inseticida sobre abelhas confinadas. Os resultados obtidos indicam que a astilbina reduz a sobrevivência média das abelhas tratadas.In this communication we have evaluated the toxic properties of methanol extracts from flowers, peduncles, leaves, petioles and stem bark of Dimorphandra mollis to Apis mellifera workers. Astilbin (5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-β-O-rhamnoside) has been isolated from peduncles and flowers of this plant in large amounts. Astilbin presented insecticidal activity against confined bees. The results suggest that astilbin reduces the average survival of treated bees.

show abstract

Section: Resultsmentioning

confidence: 99%

Toxicity of Dimorphandra mollis to Workers of Apis mellifera

Cintra

Malaspina

Petacci³

et al. 2002

J. Braz. Chem. Soc.

View full text Add to dashboard Cite

show abstract

“…Of both compounds only astilbin has the catechol orientation. Both astilbin and taxifolin (2, 3-dihydro quercetin), its aglycone, have been demonstrated to protect against oxidative damage [136]. Therefore, the antioxidant flavonoids such as engeletin and astilbin are potentially useful for therapeutic prevention of diabetic complications resulting from AGEs accumulation [137].…”

Section: `-O-[β -D-apiosyl (1→2)] -β -D-glucopyranosyl] -5-hydroxyl-mentioning

confidence: 99%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

View full text Add to dashboard Cite

“…org/content/vol53/issue3). This flavonoid shows properties of coenzyme A reductase inhibition (3 ), aldose reductase inhibition (4 ), and antioxidation (5,6 ). In our previous work (7,8 ), astilbin significantly inhibited both ear contact dermatitis and liver injury induced by delayed-type hypersensitivity (DTH) at the effector phase.…”

mentioning

confidence: 98%

Identification of a New Metabolite of Astilbin, 3′-O-Methylastilbin, and Its Immunosuppressive Activity against Contact Dermatitis

Guo

Feng

et al. 2007

Clinical Chemistry

View full text Add to dashboard Cite

Background: Astilbin is a flavonoid isolated from the rhizome of Smilax glabra. In a previous study, we revealed its unique immunosuppressive activity, a selective inhibition against activated T lymphocytes. This characteristic of astilbin is beneficial for the treatment of human immune diseases. Methods: We incubated astilbin with rat liver microsomal/cytosolic fractions and isolated the metabolite of astilbin, which was fully characterized by mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. We administered astilbin orally via a gastric tube to rats at 0.22 mmol/kg and collected whole blood samples after 30 min and urine samples after 0 to 12 h. We applied HPLC and liquid chromatography/MS to measure the metabolite in the samples, and we assayed cytokine expression by reverse-transcription PCR. Results: After incubation of astilbin with rat liver microsomal/cytosolic fractions, we detected a new metabolite of astilbin and isolated it from the culture solution. We characterized this metabolite by MS and NMR techniques as 3-O-methylated astilbin. We detected the metabolite in both blood and urine samples after oral administration of astilbin, and the metabolite inhibited picryl chloride-induced ear swelling in mice and suppressed the expression of tumor necrosis factor-␣ and interferon-␥, similarly to astilbin. Conclusion: This is the first identification of 3-Omethylastilbin as a new flavonoid, as well as an active metabolite of astilbin in vivo, and is helpful for study-

show abstract

Protection against Oxidative Damage by Dihydroflavonols inEngelhardtia chrysolepis

Cited by 79 publications

References 10 publications

Toxicity of Dimorphandra mollis to Workers of Apis mellifera

Toxicity of Dimorphandra mollis to Workers of Apis mellifera

Plant-Derived Agents with Anti-Glycation Activity

Identification of a New Metabolite of Astilbin, 3′-O-Methylastilbin, and Its Immunosuppressive Activity against Contact Dermatitis

Contact Info

Product

Resources

About