Protective Effect of Camel Milk as Anti-Diabetic Supplement: Biochemical, Molecular and Immunohistochemical Study

Mansour, Ahmed A.; Nassan, Mohamed A.; Saleh, O. M.; Soliman, Mohamed Mohamed

doi:10.21010/ajtcam.v14i4.13

Cited by 38 publications

(29 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In studies on rats, camel milk or its extracts have ameliorated biochemical and histochemical disturbances originating from DM induction. [ 12 13 14 15 ] Moreover, it has shown antidiabetic effects in human studies, as found by a systematic review. [ 16 ] Structural studies have suggested that in this kind of milk, insulin may be present in nanoparticles capable of transporting it into the bloodstream.…”

Section: Introductionmentioning

confidence: 98%

Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

et al. 2018

View full text Add to dashboard Cite

Background:This study, for the first time, aimed to assess the effects of fermented camel milk (FCM) on glycemic and inflammatory parameters related to metabolic syndrome (MetS), an aggregation of cardiometabolic risk factors, in adolescents.Materials and Methods:In a double-blind, randomized crossover trial, overweight/obese adolescents (fulfilling MetS criteria, aged 11–18 years) were randomly assigned to receive FCM 250 cc per day for an 8-week period, a 4-week washout, and then diluted cow's yogurt (DCY) 250 cc/day for another 8-week period, or the reverse sequence. Fasting blood sugar (FBS), fasting insulin, insulin resistance by three equations, incretin hormone glucose-dependent insulinotropic peptide (GIP), and glucagon-like peptide-1 (GLP1) as well as inflammatory markers such as interleukin 6 (IL6) and tumor necrosis factor-alpha (TNF-α) were measured before and after each of the four periods. A 3-day food record and physical activity questionnaire were completed before each period. Statistical analyses were done using Minitab and SPSS software considering the significance level of 0.05.Results:Twenty-four participants with a mean (standard deviation) age of 13.77 (1.87) years (range: 10.45–16.25 years) (58% girls) completed the study. It resulted in nonsignificant mean reduction in IL6 (−18.28 pg/mL [95% confidence interval [CI]: −47.48; 10.90]; P = 0.20) and nonsignificant increase in glucose metabolizing hormones such as GIP (683.10 pg/mL [95% CI: −457.84; 1824.0]; P = 0.22) and GLP1 (6.98 pg/mL [95% CI: −66.61; 80.57]; P = 0.84) by FCM consumption in comparison to DCY. Nonsignificant decrease was observed in TNF-α in the first periods of the study. The changes of FBS, fasting insulin, and insulin resistance indices were not statistically significant as well.Conclusion:According to preliminary positive influences of FCM on inflammatory markers, and findings related to glucose metabolism, we suggest conducting further studies on its clinical impacts.

show abstract

Section: Introductionmentioning

confidence: 98%

Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In some inflammatory diseases, such as hepatitis, allergies, lactose intolerance and liver damage induced by alcohol, the benefits of camel milk can be related to important immunological components such as lysozyme, lactoferrin, lactoperoxidase, etc. Besides this, antibodies of camel milk have specific structures and functions, which may result in therapeutic benefits with the mechanism of immune system regulation in inflammatory diseases (12). A study showed its ability to ameliorate severe food allergies in children in a short time with a long time interval (13).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of camel milk in comparison with standard medicinal therapy on asthma patients: a parallel clinical trial

Ravaghi¹,

Yousefi²,

Attaran³

et al. 2019

Electron. physician

View full text Add to dashboard Cite

Background: Asthma is one of the most common chronic diseases in the world by which more than 300 million people are affected. In conventional medicine for asthma treatment, more emphasis is on drug therapy, which has complications and contraindications as well as high costs, so we are investigating to identify the effect of camel's milk on the symptoms of patients with asthma. Objective: To examine the effects of camel milk in comparison with standard medicinal therapy on asthma patients. Methods: This randomized clinical trial was conducted on 46 patients with asthma. The study was conducted in Ghaem Hospital lung clinic in Mashhad, Iran, from May 2016 to November 2017. The participants were randomly divided into control and intervention groups (n, 23 per group) and were assessed both pretreatment and post treatment (before, and three months after treatment). Patients with asthma based on clinical and spirometric criteria were included in the study and divided into two groups of control and intervention. Twenty-three patients with asthma were entered into each group. The control group received routine treatments (steroid and β-agonist inhalation) and the intervention group, which received the usual treatments, plus pasteurized camel milk. Camel milk was administered two times a day (8 am and 8 pm 250 ml without additives). Data were collected using a chronic obstructive pulmonary disease (COPD) assessment test (CAT) questionnaire score and spirometry. The results were analyzed and compared in SPSS version 11.5, using paired t-test, Chi-Square test, and independent sample t-test. The significance level was set at 0.05.

show abstract

“…Camel milk has been used for controlling Diabetes Mellitus (DM) by traditional medicine. Some favorable effects of camel milk are reported in a number of animal and human diabetic populations (7)(8)(9)(10)(11)(12)(13) as follows: terminating biochemical and immunohistochemical alterations after DM induction in albino rats (7), reducing daily insulin doses in type 1 DM patients (8), reducing glycemic indices in type 2 DM patients (9), modifying hyperglycaemia and oxidative damage in animal studies (10), positive effects on incretin hormones, insulin resistance, and inflammatory cytokines (11), and promoting immune functions (12) in experimental DM. Furthermore, a systematic review has documented the beneficial effects of camel milk on DM (13).…”

Section: Introductionmentioning

confidence: 99%

Effect of Fermented Camel Milk on Obesity Measures and Blood Pressure of Adolescents With Metabolic Syndrome

et al. 2019

View full text Add to dashboard Cite

Background: Metabolic Syndrome (MetS) predisposes the human body to a variety of chronic diseases. Objectives: This study, for the first time, aimed to assess the effects of Fermented Camel Milk (FCM), a functional dairy food, on the obesity measures and blood pressure of adolescents with MetS. Methods: This was a crossover, randomized, double-blind trial. We enrolled overweight or obese adolescents, aged 11-18 years, meeting the diagnostic criteria for MetS. We randomly assigned the study participants to receive FCM 250 mL per day for 8 weeks, followed by a 4-week washout, then, consuming Diluted Cow Yogurt (DCY) 250 mL per day for 8 weeks, or the reverse sequence. General and abdominal obesity measures consisting of weight, Body Mass Index (BMI), BMI z-score, Waist Circumference (WC), Hip Circumference (HC), waist to height ratio and Systolic and Diastolic Blood Pressure (SBP, DBP) were measured before and after each of the 4 periods. A three-day food record and physical activity questionnaire were completed before each period. Statistical analyses were performed using Minitab and SPSS considering the significance level of 0.05. Results: Twenty-four participants with the Mean±SD age of 13.77±1.87 years (age range: 10.45-16.25 years) (58% girls) completed the study. It resulted in nonsignificant mean changes (increase or decrease) in weight of-0.67 kg (95%CI:-1.97; 0.61; P=0.28), BMI (-0.10 kg/m 2 , 95%CI:-0.65; 0.45; P=0.70), BMI z-score of-0.06 (95%CI:-0.33; 0.19; P=0.59), WC of-1.10 cm (95%CI:-3.22; 1.01; P=0.29), and HC of-0.12 cm (95%CI:-2.04; 1.79; P=0.89) by FCM consumption in comparison to DCY. The study also resulted in non-significant mean reduction in DBP of-4.45 mm Hg (95%CI:-10.04; 1.12; P=0.11). Conclusions: According to some positive impacts of FCM on obesity measures and blood pressure, we suggest conducting further studies to validate the clinical impacts of fermented camel milk.

show abstract

Protective Effect of Camel Milk as Anti-Diabetic Supplement: Biochemical, Molecular and Immunohistochemical Study

Cited by 38 publications

References 41 publications

Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

Effect of fermented camel milk on glucose metabolism, insulin resistance, and inflammatory biomarkers of adolescents with metabolic syndrome: A double-blind, randomized, crossover trial

Evaluation of the effect of camel milk in comparison with standard medicinal therapy on asthma patients: a parallel clinical trial

Effect of Fermented Camel Milk on Obesity Measures and Blood Pressure of Adolescents With Metabolic Syndrome

Contact Info

Product

Resources

About