Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats

Jainu, Mallika; Mohan, K. Vijai; Devi, C. S. Shyamala

doi:10.1016/j.jep.2005.08.076

Cited by 49 publications

(32 citation statements)

References 13 publications

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“…Tumor necrosis factor-α (TNF-α) amplifies the inflammatory response by activating a cascade of immune responses (Ardizzone and Bianchi, 2005). This cytokine also stimulates the production of other cytokines, arachidonic acid metabolites, and proteases (Jainu et al, 2006). Inhibition of PGE2, on the other hand, may follow that of TNF-α or may result from GE ability to inhibit cycloxygenase enzymes.…”

Section: Ginger For Digestive Healthmentioning

confidence: 99%

Ginger and its Health Claims: Molecular Aspects

Butt

Sultan

2011

Critical Reviews in Food Science and Nutrition

170

115

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Recent research has rejuvenated centuries-old traditional herbs to cure various ailments by using modern tools like diet-based therapy and other regimens. Ginger is one of the classic examples of an herb used for not only culinary preparations but also for unique therapeutic significance owing to its antioxidant, antimicrobial, and anti-inflammatory potential. The pungent fractions of ginger, namely gingerols, shogaols, paradols, and volatile constituents like sesquiterpenes and monoterpenes, are mainly attributed to the health-enhancing perspectives of ginger. This review elucidates the health claims of ginger and the molecular aspects and targets, with special reference to anticancer perspectives, immunonutrition, antioxidant potential, and cardiovascular cure. The molecular targets involved in chemoprevention like the inhibition of NF-κB activation via impairing nuclear translocation, suppresses cIAP1 expression, increases caspase-3/7 activation, arrests cell cycle in G2 + M phases, up-regulates Cytochrome-c, Apaf-1, activates PI3K/Akt/I kappaB kinases IKK, suppresses cell proliferation, and inducts apoptosis and chromatin condensation. Similarly, facts are presented regarding the anti-inflammatory response of ginger components and molecular targets including inhibition of prostaglandin and leukotriene biosynthesis and suppression of 5-lipoxygenase. Furthermore, inhibition of phosphorylation of three mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinases 1 and 2 (ERK1/2), and c-Jun N-terminal kinase (JNK) are also discussed. The role of ginger in reducing the extent of cardiovascular disorders, diabetes mellitus, and digestive problems has also been described in detail. Although, current review articles summarized the literature pertaining to ginger and its components. However, authors are still of the view that further research should be immediately carried out for meticulousness.

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Section: Ginger For Digestive Healthmentioning

confidence: 99%

Ginger and its Health Claims: Molecular Aspects

Butt

Sultan

2011

Critical Reviews in Food Science and Nutrition

170

115

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“…This cytokine stimulates also the production of other cytokines, arachidonic acid metabolites, and proteases (Jainu et al, 2006). Infiltration of inflammatory cells, such as neutrophils, in addition to the overproduction of pro-inflammatory cytokines (Dionne et al, 1997) ultimately gives rise to mucosal disruption and ulceration (Fiocchi, 1998).…”

Section: Introductionmentioning

confidence: 99%

Modulating effect of ginger extract on rats with ulcerative colitis

El‐Abhar

Hammad

Gawad

2008

Journal of Ethnopharmacology

135

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“…Different classes of drugs are used in the treatment of peptic ulcer but most of these drugs exhibit serious side effects like arrhythmias, gynaecomastia, impotence, arthralgia, hypergastrinemia and haemopoeitic changes 7 . Alternative approach in recent days is the research of medicaments from Ayurvedic or traditional medicinal system.…”

mentioning

confidence: 99%

Untitled

2013

IJPSR

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Peptic ulcer is the most common gastrointestinal disorder in clinical practice. A number of drugs including proton pump inhibitors and H 2 receptor antagonists are available for the treatment of peptic ulcer, but these drugs has shown incidence of relapses, side effects, and drug interactions. Thus the development of new antiulcer drugs and the search for novel molecules has been extended to herbal drugs that offer better protection and decreased relapse. Medicinal plants provide an effective and safer way in disease management. Many medicinal plants exhibit antiulcer activity and found useful in the treatment of peptic ulcer. Physalis minima has shown antiinflammatory and analgesic action in animals. In this present work, anti-ulcer effect of different extracts of Physalis minima was studied in NSAIDs induced ulcer model in albino rats. The extract at dose of 200,400 mg/kg produced significant inhibition of gastric lesion induced by NSAIDs induced ulcer. The extract reduced ulcerative lesion. The result obtained suggesting that extract possesses significant anti-ulcer activity.

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Protective effect of Cissus quadrangularis on neutrophil mediated tissue injury induced by aspirin in rats

Cited by 49 publications

References 13 publications

Ginger and its Health Claims: Molecular Aspects

Ginger and its Health Claims: Molecular Aspects

Modulating effect of ginger extract on rats with ulcerative colitis

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