Protective Effect of Colchicine on Ovarian Ischemia—Reperfusion Injury

Abstract

Our study results revealed that colchicine reduced ovarian ischemia-reperfusion injury in experimental rat ovarian torsion model. As the ovarian detorsion is the first choice of the treatment modality in the early phase, antioxidant and anti-inflammatory treatment modalities like colchicine might be used to reduce ovarian ischemia-reperfusion injury.

What is the protective effect of metformin on rat ovary against ischemia‐reperfusion injury?

“…Thus, numerous recent studies have focused on preventing or reducing the damage to ovaries incurred due to torsion/detorsion injury. In these studies, most have also focused on antioxidant and anti‐inflammatory agents to prevent ovarian IRI . In this ovarian torsion/detorsion rat model study, we tried to investigate the possible preservative effect of metformin, as its antioxidant and anti‐inflammatory properties have been mentioned in previous studies .…”

“…If the amount of ROS surpasses the capability of these antioxidant systems, oxidative stress is initiated, and this harms the tissue . Because of the importance of this balance between oxidant and antioxidant systems, many studies have focused on reducing oxidative stress using antioxidants . In this study, we investigated the balance in oxidant/antioxidant systems in tissue via the GSH/GSSG ratio.…”

“…ROS damage cell components, such as the membrane, DNA, and mitochondria. Recently, numerous free‐radical scavengers with anti‐inflammatory and antioxidant properties have been investigated in terms of protection of the ovary from ischemia‐reperfusion injury (IRI); some of them, such as metamizole, colchicine, and sildenafil, have been demonstrated to have a protective effect on the ovary against IRI …”

“…Recently, numerous free-radical scavengers with anti-inflammatory and antioxidant properties have been investigated in terms of protection of the ovary from ischemia-reperfusion injury (IRI); some of them, such as metamizole, colchicine, and sildenafil, have been demonstrated to have a protective effect on the ovary against IRI. [5][6][7] Reduced glutathione (GSH) is mostly described as an important intracellular and extracellular defensive antioxidant. 8 Total GSH consists of two forms, namely a free form and a form that is bound to proteins in the cells.…”

Adnexal torsion in adolescents

“…Assuming that detorsion can provoke this injury and alone is insufficient to protect ovarian reserve as the follicle count decreases (Ozler et al [38]), several agents, including antiinflammatories and antioxidant drugs, have been evaluated to determine whether they have a protective effect [36]. Experimental studies were performed on rat ovaries to demonstrate the role of different drugs in the protection of ovarian function [36,[39][40][41][42][43][44][45][46][47][48][49][50][51][52][53]. Gradual detorsion can also reduce reperfusion injury in a rat model of ovarian torsion [37].…”