Protective effect of ?-cysteine and glutathione on the modulated suckling rat brain Na+,K+-ATPase and Mg2+-ATPase activities induced by the in vitro galactosaemia

Tsakiris, Stylianos; Schulpis, Kleopatra H.; Marinou, Kyriakoula; Behrakis, Panagiotis

doi:10.1016/j.phrs.2003.11.006

Cited by 118 publications

(62 citation statements)

References 17 publications

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“…The tissue homogenate was centrifuged at 10000 RPM for 10 min at 4°C and the supernatant was separated for the below given biochemical estimation (Tsakiris et al, 2004). Another half of brain of each rat was used for histoplathological study.…”

Section: Estimation Of Biochemical Parameter Brain Tissue Homogenate mentioning

confidence: 99%

Neuroprotective Effect of Amorphophallus Campanulatus in STZ Induced Alzheimer Rat Model

Chen

2016

Afr J Tradit Complement Altern Med

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Background: The present investigation deals with the assessment of neuroprotective effect Amorphophallus campanulatus (AC) tuber in alzheimer diseased (AD) rat and also postulates its possible mechanism of action.Material and Methods: AD was induced by administering streptozotocin i.e. STZ (3 mg/kg, ICV) day one and 3 rd day after surgery.Surgery was performed on anesthetized rats by the help of stereotaxic apparatus. STZ induced AD rats were treated with petroleum ether extract of AC (100, 200 and 500 mg/kg, p.o.) for 14 days. Effect of AC tuber in AD rats were assessed by estimating the alteration in the behavior (Y maze apparatus and single trail passive avoidance), biochemical parameter in the brain tissue {Oxidative stress parameters (SOD, CAT and LPO), amyloid β peptide (Aβ) and acetylcholinesterase (AchE)} and histopathological study of brain tissue.Result: Treatment with AC shows significant (p<0.01) increased in the % of alteration in the behavior and step through latency in Y maze task and single trial passive avoidance test compared to AD rats. AC significantly (p<0.01) decreases the Aβ1-40, Aβ1-42 peptides and AchE in the brain tissue compared to AD rats. Whereas, treatment with AC significantly reduces the oxidative stress level in AD rats.Histopathological study reveals that treatment with AC extract reduces the amyloid plaque formation in the brain tissue of AD rat. Conclusion:The present study concludes the neuroprotective effect of AC extract in AD rats by reducing oxidative stress, Aβ and AchE in the brain tissue.

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Section: Estimation Of Biochemical Parameter Brain Tissue Homogenate mentioning

confidence: 99%

Neuroprotective Effect of Amorphophallus Campanulatus in STZ Induced Alzheimer Rat Model

Chen

2016

Afr J Tradit Complement Altern Med

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“…15 The homogenate was centrifuged at 500× g for 10 minutes, at 4°C. The supernatant (10%) was used for the various biochemical determinations.…”

Section: Biochemical Analysismentioning

confidence: 99%

Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum

Dkhil¹,

Al‐Quraishy²,

Wahab³

2015

IJN

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Nanomedicine has recently emerged as a better option for the treatment of various diseases. Here, we investigated the in vivo anticoccidial properties of zinc oxide nanoparticles (ZNPs). ZNPs were crystalline in nature, with a smooth and spherical surface and a diameter in the range of ~10–15 nm. The X-ray diffraction pattern was utilized to identify the crystalline property of the grown ZNPs, whereas field emission scanning electron microscopy was employed to check the size and morphology of the ZNPs. The data showed that mice infected with Eimeria papillata produced 29.7×10 3 ±1,500 oocysts/g feces on day 5 postinfection. This output was significantly decreased, to 12.5×10 3 ±1,000 oocysts, in mice treated with ZNPs. Infection also induced inflammation and injury of the jejunum. This was evidenced (1) through an increase in the inflammatory histological score, (2) through increased production of nitric oxide and malondialdehyde, and (3) through a decrease in both the glutathione level and goblet cell number in mice jejuna. All these infection-induced parameters were significantly altered during treatment with ZNPs. Our results indicate, therefore, that ZNPs have protective effects against E. papillata -induced coccidiosis.

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“…The first portion of each brain was weighed and homogenized to give 10 % (w/v) homogenate in ice cold medium containing 50 mM Tris-HCl and 300 mM sucrose at pH 7.4 [10]. The homogenate was centrifuged at 3,000 rpm for 10 min in cooling centrifuge at 4°C.…”

Section: Preparation Of Homogenatesmentioning

confidence: 99%

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

et al. 2012

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This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl 3 to induce AD and ADinduced rats treated with melatonin. Hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.

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Protective effect of ?-cysteine and glutathione on the modulated suckling rat brain Na+,K+-ATPase and Mg2+-ATPase activities induced by the in vitro galactosaemia

Cited by 118 publications

References 17 publications

Neuroprotective Effect of Amorphophallus Campanulatus in STZ Induced Alzheimer Rat Model

Neuroprotective Effect of Amorphophallus Campanulatus in STZ Induced Alzheimer Rat Model

Anticoccidial and antioxidant activities of zinc oxide nanoparticles on Eimeria papillata-induced infection in the jejunum

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

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