Protective effect of date extract on rat nephrotoxicity induced by gentamicin, clinical, histological and antioxidant evidences

Çelik, Özgür; Irak, Kıvanç

doi:10.14715/cmb/2018.64.14.18

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…In addition, myristic acid has revealed a nephroprotective effect by reducing tubular necrosis in an experimental model of AKI 43 . Finally, the fact that extracts obtained from Cocos nucifera and Phoenix dactylifera, palms with fatty acid compositions similar to D-005, have demonstrated protection against gentamicin-induced nephrotoxicity supports our hypothesis 11 , 12 .…”

Section: Discussionsupporting

confidence: 75%

“…In this sense, the best protection results have been obtained with antioxidant extracts from plants, being administered concomitantly with the AMG, either simultaneously or as a pre-treatment on the same day 10 . Examples of this are the antioxidant extracts from two species of Arecaceae (Cocos nucifera and Phoenix dactylifera) exhibiting protective effects against AKI, which were administered concomitantly with gentamicin 11 , 12 .…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidant agents are among the best candidates due to their efficacy in preventing the generation of reactive oxygen species 8 - 10 . According to this approach, extracts obtained from plants belonging to Arecaceae family, such as Cocos nucifera and Phoenix dactylifera, have prevented gentamicin-induced AKI in rats 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

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Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

et al. 2022

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Introduction: Aminoglycoside-induced acute kidney injury (AKI) is a pathology closely linked to oxidative and inflammatory reactions. Taking into account the previous reported antioxidant and anti-inflammatory effects of D-005, a lipid extract obtained from Cuban palm Acrocomia crispa (Arecaceae) fruits, this work aimed to evaluate the effects of D-005 on kanamycin-induced AKI. Methods: Male Wistar rats were divided into 7 groups: negative control (vehicle, Tween 65/H2O) and six groups treated with kanamycin to induce AKI: positive control (vehicle), D-005 (25, 100, 200, and 400 mg/kg) and grape seed extract (GSE, 200 mg/kg). D-005, vehicle, and GSE oral treatments were administered once daily for seven days, 1 h before kanamycin (500 mg/kg, i.p.). Serum uric acid and urea concentrations, renal histopathology, and oxidative markers (malondialdehyde (MDA), sulfhydryl (SH) groups, and catalase (CAT) activity) were assessed. Results: D-005 significantly reduced uric acid and urea levels, starting from D-005 100 mg/kg. Histopathologically, D-005, at all the tested doses, protected renal parenchyma structures (glomeruli, proximal tubules, and interstitium). These findings were accompanied by a significant reduction of MDA and SH group concentrations as well as restoration of CAT activity. The highest percentages of inhibition were obtained with the dose of 400 mg/kg. GSE, the reference substance, also prevented kanamycin-induced biochemical and histopathological changes, as well as reduced MDA and SH groups and restored CAT activity. Conclusion: The administration of repeated oral doses of D-005 significantly protected against kanamycin-induced AKI, which could be associated with the antioxidant and anti-inflammatory effects of this extract.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

et al. 2022

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“…A study on rats investigated the antioxidant effect of date fruit extract against gentamicin-induced nephrotoxicity. In this study, they reported that the TAS level that gentamicin decreased in the kidney tissue, increased the date extract (Celik and Irak 2018).…”

Section: Discussionmentioning

confidence: 67%

Protective effect of krill oil against gentamicin-induced oxidative stress-mediated nephrotoxicity in rats

Şahin¹,

Alçığır²,

Şenol³

et al. 2022

Kocatepe Veterinary Journal

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This study aimed to evaluate the protective effect of krill oil against nephrotoxicity caused by gentamicin. Distilled water was given orally to the control and second groups (GI) for seven days while 500 mg/kg krill oil was given to the third (GII), fourth (GIII) groups. In addition, isotonic saline was administered subcutaneously to the control and GIII groups throughout the study, while 80 mg/kg gentamicin was administered to the GI, and GII groups. Alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) peptidase, total cholesterol, urea, and creatinine levels in plasma and, malondialdehyde (MDA) and total antioxidant status (TAS) levels in both plasma and kidney tissue supernatant were evaluated. Histopathological changes in tubules and glomeruli and vascular changes were evaluated by scoring. Urea level and ALT activity were found to be significantly lower in the GII and GIII groups compared to the GI group (p<0.001; p≤0.001). As a result, it was observed that degenerative damage and glomerular changes in the tubule at the histological level mediated by oxidative stress were consistent with the increase in ALT, urea, and MDA levels. In this respect, it is suggested that krill oil can be used as a nephroprotective food supplement to contribute to treatment in cases of toxicity.

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“…These 2 different ways of reporting urea results had the same significantly changes when we compared Gentamicin treated group with the control group and when Curcumin (CC and LCC) groups were compared with Gentamicin treated group) ( Table 4 , Figure 5 ). Celik et al also found significantly increased biomarkers for renal function after Gentamicin administration [ 70 ]. Whereas the new nanoformulation of curcumin therapy (liposomal Curcumin) had a better efficiency on renal function biomarkers, we consider that liposomal curcumin pretreatment could significantly contribute to the preservation of renal function in Gentamicin induced nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Liposomal Curcumin on Oxidative Stress/Antioxidant Imbalance, Metalloproteinases 2 and -9, Histological Changes and Renal Function in Experimental Nephrotoxicity Induced by Gentamicin

et al. 2021

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Background: Our study aimed to assess the efficiency of Curcumin nanoformulation (LCC) on experimental nephrotoxicity induced by Gentamicin in rats. Methods: Six groups of seven rats were used: C—(control group) received saline solution i.p. (i.p. = intraperitoneal), G—gentamicin (G, 80 mg/kg body weight (b.w.)), GCC1 and GCC2—with G and CC solution (single dose of 10 mg/kg b.w.-CC1, or 20 mg/kg b.w.-CC2), GLCC1 (10 mg/kg b.w.) and GLCC2 (20 mg/kg b.w.) with G and LCC administration. Oxidative stress parameters (NOx = nitric oxide, MDA = malondialdehyde, TOS = total oxidative stress), antioxidant parameters (CAT = catalase, TAC = total antioxidant capacity), matrix metalloproteinases (MMP-2 and MMP-9), and renal function parameters (creatinine, blood urea nitrogen, and urea) were measured. Kidneys histopathologic examination was made for each group. Results: Pretreatment with CC and LCC in both doses had significantly alleviating effects on assessed parameters (NOx, MDA, TOS, CAT, TAC, MMP-2, and -9) as compared with the untreated group (p < 0.006). Histopathological aspect and renal function were significantly improved in CC and LCC groups. Liposomal formulation (LCC) showed higher efficiency on all examined parameters compared to CC (p < 0.006). Conclusions: Our results demonstrated improving renal function and kidney cytoarchitecture, oxidative stress/antioxidant/balance, and MMPs plasma concentrations with better dose-related efficacity of LCC than CC.

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Protective effect of date extract on rat nephrotoxicity induced by gentamicin, clinical, histological and antioxidant evidences

Cited by 7 publications

References 28 publications

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

Protective effect of krill oil against gentamicin-induced oxidative stress-mediated nephrotoxicity in rats

Protective Effects of Liposomal Curcumin on Oxidative Stress/Antioxidant Imbalance, Metalloproteinases 2 and -9, Histological Changes and Renal Function in Experimental Nephrotoxicity Induced by Gentamicin

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