Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis

Oh, Sarang; Ok, Seon; Jung, Timothy; Jeon, Sang-Ok; Park, Ji-Min; Jung, Junhee; Ryu, Deok‐Seon

doi:10.1016/j.apjtm.2017.08.017

Cited by 33 publications

(15 citation statements)

References 44 publications

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“…In UC pathogenesis, increased secretions of the pro-inflammatory cytokines IL-6, TNF-α, and IFN-γ are closely implicated with intestinal inflammatory responses. IL-6 elevates the body temperature by inducing production of acute-phase response proteins, accompanied with the infiltration of inflammatory immune cells and increased permeability of vascular endothelial cells by TNF-α [13]. The clinical application of TNF-α and IL-6 antagonists (e.g., infliximab, adalimumab, and tocilizumab) demonstrated therapeutic effects against acute and chronic UC.…”

Section: Resultsmentioning

confidence: 99%

Preventive Effects of an UPLC-DAD-MS/MS Fingerprinted Hydroalcoholic Extract of Citrus aurantium in a Mouse Model of Ulcerative Colitis

Hwang

Yeul

2018

Planta Med

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Although traditionally used to improve indigestion, diarrhea, dysentery, and constipation, the therapeutic effects of on intestinal inflammation remain unclear. The aim of this study was to evaluate the beneficial effects and to identify the active components of a hydroalcoholic extract of (HECA) on ulcerative colitis. HECA was prepared with 70% ethanol solution in water and extracted at 37 °C for 12 h in triplicate, filtered through a sieve, and lyophilized. Phytochemical identification of HECA was performed by ultra-performance liquid chromatography-diode array detector-tandem mass spectrometry (UPLC-DAD-MS/MS). Animals were randomly assigned to one of four groups based on the treatment conditions. Ulcerative colitis was induced by administration of 2.5% dextran sodium sulfate (DSS) in drinking water for 5 d. Body weight, clinical signs, colon length, pro-inflammatory cytokine expression levels, and histopathological findings were evaluated. In UPLC-DAD-MS/MS analysis, the identified phytochemical components of HECA included four alkaloids, seven coumarins, 18 flavonoids, two lignans, two phenolics, and 10 terpenoids. HECA markedly protected against body weight loss and colon shortening. In pathological examination, HECA alleviated DSS-related mucosal inflammatory lesions in the colon. Moreover, HECA markedly reduced the expression levels of interleukin-6, interferon-, tumor necrosis factor-, and monocyte chemotactic protein-1 in colonic inflammation. Taken together, HECA has potential to relieve mucosal inflammation in the colon, suggesting that the putative active ingredients are responsible for the anti-ulcerative effects.

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Section: Resultsmentioning

confidence: 99%

Preventive Effects of an UPLC-DAD-MS/MS Fingerprinted Hydroalcoholic Extract of Citrus aurantium in a Mouse Model of Ulcerative Colitis

Hwang

Yeul

2018

Planta Med

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“…5 We were unable to identify which herbs the patient ingested; however, Angelica gigas Nakai, Cnidium officinale Makino, Citrus unshiu Markovich, and Glycyrrhiza uralensis Fischer are thought to be useful for anemia in Korea, so it can be speculated that the patient could have ingested these herbs. Angelica gigas Nakai is known to reduce cardiac contraction, 8 but there are no reports that it causes arrhythmia; the three other herbs also lack evidence of cardiac toxicity. Therefore, she might have taken additional herbs and one or more of them could have caused the refractory VT.…”

Section: Discussionmentioning

confidence: 99%

Intravenous lipid emulsion therapy for cardiac arrest and refractory ventricular tachycardia due to multiple herb intoxication

2019

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Herbal products have been used for therapeutic purposes for a long time. However, many herbs can be toxic and even life-threatening. If refractory ventricular tachycardia (VT) is caused by herbal products and shows no response to conventional therapy, intravenous lipid emulsion (ILE) therapy can be considered. We report a case of herbal intoxication leading to refractory VT, which was successfully treated with ILE therapy. A 36-year-old woman with aplastic anemia presented with mental changes. She had taken an unknown herbal decoction three days before visiting the hospital. Soon after coming to the hospital, she went into cardiac arrest. Cardiopulmonary resuscitation was performed, and return of spontaneous circulation with VT was achieved. Synchronized cardioversion was then performed and amiodarone was administered. However, VT with pulse continued, so ILE therapy was attempted, which led to the resolution of VT.

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“…An acute toxicity test of AGNE determined that the LD50 was >2000 mg/kg. The dosage used in our experiment was determined based on the dosage verified in a previous study of the positive effects of AGNE on ulcerative colitis [ 19 , 20 ]. Also, the dosage was within the range in which terfenadine does not cause adverse reactions [ 21 ].…”

Section: Methodsmentioning

confidence: 99%

Effects of Angelica gigas Nakai as an Anti‐Inflammatory Agent in In Vitro and In Vivo Atopic Dermatitis Models

Ok¹,

Oh²,

Jung³

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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We investigated the cellular and molecular mechanisms mediating the effects of Angelica gigas Nakai extract (AGNE) through the mitogen-activated protein kinases (MAPKs)/NF-κB pathway using in vitro and in vivo atopic dermatitis (AD) models. We examined the effects of AGNE on the expression of proinflammatory cytokines and chemokines in human mast cell line-1 (HMC-1) cells. Compound 48/80-induced pruritus and 2,4-dinitrochlorobenzene- (DNCB-) induced AD-like skin lesion mouse models were also used to investigate the antiallergic effects of AGNE. AGNE reduced histamine secretion, production of proinflammatory cytokines including interleukin- (IL-) 1β, IL-4, IL-6, IL-8, and IL-10, and expression of cyclooxygenase- (COX-) 2 in HMC-1 cells. Scratching behavior and DNCB-induced AD-like skin lesions were also attenuated by AGNE administration through the reduction of serum IgE, histamine, tumor necrosis factor-α (TNF-α), IL-6 levels, and COX-2 expression in skin tissue from mouse models. Furthermore, these inhibitory effects were mediated by the blockade of the MAPKs and NF-κB pathway. The findings of this study proved that AGNE improves the scratching behavior and atopy symptoms and reduces the activity of various atopy-related mediators in HMC-1 cells and mice model. These results suggest the AGNE has a therapeutic potential in anti-AD.

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Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis

Abstract: The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC.

Cited by 33 publications

References 44 publications

Preventive Effects of an UPLC-DAD-MS/MS Fingerprinted Hydroalcoholic Extract of Citrus aurantium in a Mouse Model of Ulcerative Colitis

Preventive Effects of an UPLC-DAD-MS/MS Fingerprinted Hydroalcoholic Extract of Citrus aurantium in a Mouse Model of Ulcerative Colitis

Intravenous lipid emulsion therapy for cardiac arrest and refractory ventricular tachycardia due to multiple herb intoxication

Effects of Angelica gigas Nakai as an Anti‐Inflammatory Agent in In Vitro and In Vivo Atopic Dermatitis Models

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