Protective Effect of Ethanol Extract Tempuyung Leaf (Sonchus arvensis L.) Against Gentamicin Induced Renal Injury Viewed from Blood Ureum Level

Imelda, Imelda; Azaria, Cherry; Lucretia, Teresa

doi:10.28932/jmh.v1i6.555

Cited by 5 publications

(5 citation statements)

References 9 publications

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“…Decreased serum urea and creatinine levels revealed an improvement in kidney function of the test animals [30][31][32]. These findings are in line with the report of Imelda et al showed that Sonchus arvensis L. 100 and 200 mg/kg b.w reduced serum urea and creatinine levels after administration of Sonchus arvensis L. extract and gentamicin for ten days, simultaneously [10,33].…”

Section: Discussionsupporting

confidence: 87%

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

Suliska¹,

Praviska²,

Kurniati³

et al. 2021

jrp

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Kidney failure is characterized by a decrease in the glomerular filtration rate, albuminuria, increased serum creatinine and blood urea nitrogen levels, abnormalities in kidney histology, and electrolyte disturbances. Sonchus arvensis L. contain high antioxidants such as flavonoids, glycosides, alkaloids, steroids/triterpenoids, tannins, saponins, and quinones, so it has the potential to improve kidney function. Twenty-five male Wistar albino rats were divided into five groups: negative control, positive control (induction of kidney failure), and three test groups which were administered an ethanol extract of Sonchus arvensis L. leaves of 50, 100, and 150 mg/kg b.w doses, respectively. Rats kidney failure model were using gentamycin 100 mg/kg b.w. and piroxicam, 3.6 mg/kg b.w. induction. Sonchus arvensis L. extracts were then administered for four weeks. The parameters for nephroprotective of Sonchus arvensis L. were urea and serum creatinine levels, urine volume, kidney organ histology, TBARS, and catalase activity. There was an improvement in kidney function as all Sonchus arvensis L. dosage levels were characterized by a significant decrease in serum urea levels (25-30%) and serum creatinine (16-23%), as well as significantly increased urine volume (83-167%) in the third week of therapy. At the end of treatment, there was a decrease in the TBARS levels (7-17%) and increased catalase activity (41-62%), significantly in all the treatment groups. The best effect was seen when using the 150 mg/kg b.w. the dose of Sonchus arvensis L. extract.

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Section: Discussionsupporting

confidence: 87%

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

Suliska¹,

Praviska²,

Kurniati³

et al. 2021

jrp

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“…The involvement of oxidative stress can cause the amount of antioxidant status to decrease [42]. Oxidative stress condition is defined as imbalance condition between antioxidants and free radicals, where the state of free radicals is higher than antioxidants [14]. The number of antioxidants decreases because the body used to balance the high free radicals due to the presence of parasites.…”

Section: Discussionmentioning

confidence: 99%

“…In Indonesia, Sonchus arvensis L., a highly invasive species of the family Asteraceae, is used as a traditional medicinal plant for malaria treatment [10]. This plant contains various active compounds including flavonoids, saponins, and polyphenols [11], which have been reported for moderate to high antioxidant [12], hepatoprotective [13], nephroprotective [14], anti-inflammatory [15], and antibacterial activities [16][17][18]. Although S. arvensis L. has pharmaceutical benefits, it has never been evaluated for in vivo treatment of malaria.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antiplasmodial activities of leaf extracts from Sonchus arvensis L.

Wahyuni

Wacharasindhu

Bankeeree

et al. 2023

BMC Complement Med Ther

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Background Malaria continues to be a global problem due to the limited efficacy of current drugs and the natural products are a potential source for discovering new antimalarial agents. Therefore, the aims of this study were to investigate phytochemical properties, cytotoxic effect, antioxidant, and antiplasmodial activities of Sonchus arvensis L. leaf extracts both in vitro and in vivo. Methods The extracts from S. arvensis L. leaf were prepared by successive maceration with n-hexane, ethyl acetate, and ethanol, and then subjected to quantitative phytochemical analysis using standard methods. The antimalarial activities of crude extracts were tested in vitro against Plasmodium falciparum 3D7 strain while the Peter's 4-day suppressive test model with P. berghei-infected mice was used to evaluate the in vivo antiplasmodial, hepatoprotective, nephroprotective, and immunomodulatory activities. The cytotoxic tests were also carried out using human hepatic cell lines in [3(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Result The n-hexane, ethyl acetate, and ethanolic extracts of S. arvensis L. leaf exhibited good in vitro antiplasmodial activity with IC50 values 5.119 ± 3.27, 2.916 ± 2.34, and 8.026 ± 1.23 μg/mL, respectively. Each of the extracts also exhibited high antioxidant with low cytotoxic effects. Furthermore, the ethyl acetate extract showed in vivo antiplasmodial activity with ED50 = 46.31 ± 9.36 mg/kg body weight, as well as hepatoprotective, nephroprotective, and immunomodulatory activities in mice infected with P. berghei. Conclusion This study highlights the antiplasmodial activities of S. arvensis L. leaf ethyl acetate extract against P. falciparum and P. berghei as well as the antioxidant, nephroprotective, hepatoprotective, and immunomodulatory activities with low toxicity. These results indicate the potential of Sonchus arvensis L. to be developed into a new antimalarial drug candidate. However, the compounds and transmission-blocking strategies for malaria control of S. arvensis L. extracts are essential for further study.

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“…The diuretic effect obtained comes from ethanol extract of tempuyung leaves with the active antioxidant content of flavonoids. Research shows the effect of protection of ethanol extract tempuyung against kidney injury [14]. In addition, tempuyung leaves can be used as a diuretic drug because they have a high potassium chemical compound content.…”

Section: Diureticsmentioning

confidence: 99%

An Overview of the Traditional Uses, Phytochemicals, and Pharmacological Activities of Tempuyung (Sonchus arvensis L.)

Wulandari¹,

Chandra²,

Zulharmita³

et al. 2021

IJPSM

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Tempuyung (Sonchus arvensis L.) is one of the herbs that the community has widely known. This plant is easy to come by and has excellent benefits. Therefore, it is necessary to obtain information about phytochemicals and their pharmacological effects. Information search is done by literature studies in primary data or official book forms and international journals through trusted websites such as Mendeley, Scopus, ScienceDirect, NCBI, ResearchGate, Google Scholar, Pubmed. The results showed tempuyung has phytochemical compounds, especially flavonoids and derivatives such as kaempferol, rutin, and quercetin. This compound is isolated from the leaves of tempuyung by various extraction methods. Pharmacologically, this plant has been reported to have antibacterial and antiviral, diuretic, kidney stones, antihistamine, antihypertensive, and antihyperuricemia. Thus, tempuyung can be used as an ingredient for traditional medicine, and further research needs to be done to isolate medicinal compounds from tempuyung.

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Protective Effect of Ethanol Extract Tempuyung Leaf (Sonchus arvensis L.) Against Gentamicin Induced Renal Injury Viewed from Blood Ureum Level

Cited by 5 publications

References 9 publications

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

Nephroprotective effect of ethanol extract of Sonchus arvensis L. leaves in gentamicin-piroxicam induced rat renal failure

In vitro and in vivo antiplasmodial activities of leaf extracts from Sonchus arvensis L.

An Overview of the Traditional Uses, Phytochemicals, and Pharmacological Activities of Tempuyung (Sonchus arvensis L.)

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