Protective effect of ethanolic extract of leaf and seed of Tamarindus indica on paracetamol induced hepatotoxicity in rats

Shammi, NJ; Choudhry, ZK; Khan, Muhammad Issa; Hossain, MM

doi:10.3329/jdmc.v21i1.13232

Cited by 1 publication

(6 citation statements)

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“…Most studies that use medicinal plants show effects similar to those found in this study [11][12][13][14][15] , however all perform prophylactic treatment of toxic hepatitis, similar to PCG1 and PCG7. However, studies should focus on the analysis of the therapeutic effect of the oils, whereas hardly identifies the patients who abuse acetaminophenin before they show hepatitis.…”

Section: Discussionsupporting

confidence: 50%

“…The acetaminophenin the dose used, showed hepatotoxic effects perceived by increased dosage of ALT and AST in the control group 11,12,14 , and the copaiba oil showed no effects when administered prophylactically during a day, however for 7 days and prophylactic therapy showed similar results to those animals treated with N-Acetyl-Cysteine, showing a hepatoprotective potential of this oil.…”

Section: Discussionmentioning

confidence: 50%

“…One mechanism of liver injury caused by acetaminophenin is the production of free radicals leading to apoptosis and necrosis 3,7,12 . The oil of copaiba demonstrably can attenuate the production of free radicals due to its anti-inflammatory, and the effect of copaiba oil in liver transaminases had already been identified by Noguchi et al 20 , suggesting a hepatoprotective real potential of this oil.…”

Section: Discussionmentioning

confidence: 99%

“…Studies shows an effect of the plants in reduce liver damage caused by acetaminophen and some others with similar results comparing with N-AcetylCysteine, the gold standard for the treatment of this kind of liver failure [11][12][13][14][15] . This practice has been encouraged by the World Health Orgaznization 16 .…”

Section: Introductionmentioning

confidence: 97%

“…The acetaminophen and N-acetyl-cysteine were administered by gavage at a dose of 2 g/kg and 1.2 g/kg, respectively 11,12 .…”

Section: Approved By the Ethicsmentioning

confidence: 99%

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Effect of copaiba oil in hepatic damage induced by acetaminophen in rats

Teixeira

Yamaki²,

Yasojima

et al. 2013

Acta Cir. Bras.

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PURPOSE:To investigate the effects of copaiba oil on the hepatic damage induced by paracetamol.METHODS Thirty six rats were distributed into six study groups (N=6): control group, that didn't receive the acetaminophen; Acetaminophen Group, that only received the acetaminophen; Prophylactic Copaiba Group 1, that received copaiba oil two hours before the acetaminophen; Prophylactic Copaiba Group 7, that received copaiba oil seven days, once by day, before the acetaminophen; Therapy Copaiba Group, that received the copaiba oil two hours afther the acetaminophen; and N-Acetyl-Cysteine Group, , that received the N-Acetyl-Cysteine two hours afther the acetaminophen. Euthanasia was performed after 24 hours. The serum levels of AST, ALT, alkaline phosphatase, GT, total bilirubin, direct bilirubin and indirect bilirubin and histological analisis were analized. RESULTS:The prophylactic copaiba group 7, therapy copaiba group and N-Acetyl-Cysteine Group showed amounts of AST and ALT similar to the control group; and the prophylactic copaiba group 1 showed similar levels to the acetaminophen group. There was no significant difference between the groups regarding the amount of alkaline phosphatase and GT (p>0.05). The therapy copaiba group showed the highest levels of bilirubin and was statistically different from the other groups (p<0.01) and this increased the costs of direct bilirubin. Regarding histopathology, the oil of copaiba administered prophylactic or therapeutic form for 7 days could decrease the amount of necrosis and inflammatory infiltrate. CONCLUSION:Copaiba oil administered prophylactically for seven days, and therapeutic could reduce liver damage caused by paracetamol similarly N-Acetyl-Cysteine, however, when treated with copaiba therapeutically showed increases in bilirubin, costs increasing fraction indirect.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 50%