Protective Effect of Ethanolic Extract of<i>Tabernaemontana divaricata</i>(L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

Kannappan, Poornima; Palanisamy, Chella Perumal; Gopalakrishnan, Vishrawas

doi:10.1155/2014/240243

Cited by 26 publications

(12 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, slight necrosis and vacuolation in liver and kidney tissues were observed in animals treated with 1500 mg/kg of mixture. These finding are in consistence with previous studies on single plant extracts on microanatomy of kidney up to 2000 mg/kg BW [ 38 , 39 ]. Our studies indicate that the plants are safe individually till 2000 mg/kg BW, but their combination could cause necrosis in the tissues at 1500 mg/kg body weight.…”

Section: Discussionsupporting

confidence: 92%

Antilisterial Effect ofRosa damascenaandNymphaea albainMus musculus

Batool

Kalsoom

Akbar

et al. 2018

BioMed Research International

View full text Add to dashboard Cite

The present study was proposed to investigate the toxicological and prophylactic potential of ethanolic extracts of Rosa damascena and Nymphaea alba and their mixture in albino mice. For toxicity study, three different doses of plant extracts were orally administrated to three groups of mice for 14 successive days. Blood biochemistry and histological examinations of liver and kidney revealed that these extracts had no harmful effects up to 1000 mg/kg. To determine the prophylactic effects of Rosa damascena, Nymphaea alba, and their mixture, an infection model of Listeria monocytogenes was established in a pilot study. Establishment of infection was confirmed by changes in haematological parameters and reisolation of Listeria monocytogenes from different tissues. Results showed that these extracts alone or in combination could restrict the growth of Listeria monocytogenes in different organs. Neutrophils were high in positive control group but remained in normal range in all treated groups. Listeria monocytogenes was recovered in low numbers from animals treated with extract of single plant but was negligible in group treated with mixture of extract of plants. Platelets count was increased in treated groups as compared to control. Results confirmed that these extracts are potent source of antimicrobial compounds and that they have synergistic effect in combined form.

show abstract

Section: Discussionsupporting

confidence: 92%

Antilisterial Effect ofRosa damascenaandNymphaea albainMus musculus

Batool

Kalsoom

Akbar

et al. 2018

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Similarly, the hepatoprotective activity of Catharanthus roseus leaves extract was reported in simvastatin‐induced hepatotoxicity in rats (Ahmed & Srinivasa Rao, ). Moreover, the hepatoprotective activity of ethanolic extract of the whole plant of Tabernaemontana divaricata was reported in DEN as well as Fe NTA‐induced liver injury in Wistar albino rats (Poornima, Chella Perumal, & Gopalakrishnan, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Bhadane¹,

Patil²,

Maheshwari

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

The family Apocynaceae is one of the largest and important families in angiosperm. Several members of this family have medicinal properties and have been in the treatment of various ailments. Most of them are consumed as food by tribal people whereas a few plants are used as source of poison. Members of family Apocynaceae are rich in alkaloids, terpenoids, steroids, flavonoids, glycosides, simple phenols, lactones, and hydrocarbons. Other compounds such as sterols, lignans, sugars, lignans, and lactones have been isolated and systematically studied. Few studies have reported antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities of crude extracts as well as single compound(s) isolated from various members of the family Apocynaceae. Holarrhena antidysenterica, Rauvolfia serpentina, Carissa carandas, and Tabernaemontana divaricata are the extensively studied plants in this family. The present review provides a detailed outlook on ethnopharmacology, phytochemistry, and biological activities of selected members of this family. Moreover, it also covers the biotechnological advances used for large-scale production of bioactive compounds of therapeutic interest along with plant tissue culture-based approaches for conservation of this medicinally valuable family.

show abstract

“…[5] A large proportion of the world population depends on the traditional medicine partly because it is comparatively effective with less/no side effects when compared with orthodox medicines and/or the bioactive compounds from the medicinal plants play a central role in the development of novel drug for the treatment and prevention of human diseases. [6]…”

Section: Introductionmentioning

confidence: 99%

Screening of potential phytocompounds from Euclea crispa (Thunb.) leaves targeting human epidermal growth factor receptor 2 (HER2) signaling pathway

Palanisamy

Ashafa

2019

J Pharm Bioall Sci

View full text Add to dashboard Cite

A BSTRACT Background: Overexpression of human epidermal growth factor receptor 2 (HER2) plays an important role in the development and progression in a variety of cancers and it is a novel therapeutic target for breast cancer and ovarian cancer. Euclea crispa ( E. crispa ) is a South African medicinal plant in the family Ebenaceae used in the management of different human diseases and disorders. Aims: The aim of this study was to evaluate the potential inhibitors against HER2 from hexane extract of E. crispa leaves. Materials and Methods: Chemical fingerprinting method was used to identify the presence of natural compounds from the extract whereas their inhibitory activities were analyzed by molecular docking analysis against HER2. Absorption, distribution, metabolism, and excretion (ADME) properties also predicted to establish the pharmacokinetics and pharmacodynamics profiles of the selected compounds. Results: The molecular docking analysis expressed that phenyl glucuronide, hydrocortisone acetate, and 6-(4,6-dioxo-1,4,5,6-tetrahydropyrimidin-2-yl-amino)hexanoic acid trifluoroacetate possess good inhibitory activities with good glide score of −6.63, −5.41, and −5.40 and glide energy of −35.03, −42.51, and −31.38 kcal/mol, respectively when compared with standard Food and Drug Administration–approved drug and other compounds. All the screened compounds were within the acceptable and permissible limits of ADME properties. Conclusion: Thus, from this study it can be concluded that, these screened natural compounds from E. crispa leaves may serve as potential inhibitors for HER2 and they might lead to development of new therapeutic agents against cancer and its associated complications.

show abstract

Protective Effect of Ethanolic Extract ofTabernaemontana divaricata(L.) R. Br. against DEN and Fe NTA Induced Liver Necrosis in Wistar Albino Rats

Cited by 26 publications

References 25 publications

Antilisterial Effect ofRosa damascenaandNymphaea albainMus musculus

Antilisterial Effect ofRosa damascenaandNymphaea albainMus musculus

Ethnopharmacology, phytochemistry, and biotechnological advances of family Apocynaceae: A review

Screening of potential phytocompounds from Euclea crispa (Thunb.) leaves targeting human epidermal growth factor receptor 2 (HER2) signaling pathway

Contact Info

Product

Resources

About