Protective Effect of Fat Extract on UVB-Induced Photoaging <i>In Vitro</i> and <i>In Vivo</i>

Deng, Mingwu; Xu, Yuda; Yu, Ziyou; Wang, Xiangsheng; Cai, Yu; Zheng, Hongjie; Li, Wei; Zhang, Wenjie

doi:10.1155/2019/6146942

Cited by 48 publications

(42 citation statements)

References 36 publications

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“…It has also been reported that the reductions in capillary diameter and volume are associated with vascular endothelial cell apoptosis via increased oxidative stress [26]. Furthermore, in UV-induced skin, the dermal thickness increased while the capillary density decreased, as recently reported by Deng et al [27]. We also found an inverse correlation between wrinkling and the levels of ROS and between wrinkling and the capillary number in the skin of mice ( Figure 6).…”

Section: Discussionsupporting

confidence: 88%

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Li¹,

Matsumoto²,

Takuwa³

et al. 2019

Preprint

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Ultraviolet (UV) induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin, a ketocarotenoid from Haematococcus pluvialis, has been extensively studied with respect to its possible effect on skin health as well as UV protection. In addition, astaxanthin attenuates increases in the generation of reactive oxygen species (ROS) and capillary regression of skeletal muscle. In the present study, we investigated whether astaxanthin would protect UV-induced photoaging and capillary regression in the skin of HR-1 hairless mice. UV induces wrinkle formation, thickness and capillary regression in dermis of hairless mice and the administration of astaxanthin decreased the UV-induced wrinkle formation, skin thickness, and increase in collagen fibers in skin. Astaxanthin supplementation also inhibited the levels of ROS generation and attenuated the decreases in wrinkle formation, thickness and capillary number in the skin. We also found an inverse correlation between wrinkling and capillary number, and the photoaging associated with capillary regression in skin. These results suggest that astaxanthin can protect against photoaging caused by ultraviolet irradiation and the effects of astaxanthin in photoaging inhibition may be associated with the protection of capillary regression in skin.

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Section: Discussionsupporting

confidence: 88%

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Li¹,

Matsumoto²,

Takuwa³

et al. 2019

Preprint

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“…Topical application of ATSC-Ex accelerates wound healing in vivo 2. ATE promotes HDF proliferation and migration and ECM protein production [ 64 ] Mingwu Deng Dermal fibroblasts were cultured with different concentrations of FE and then were exposed to UVB light Female BALB/c nude mice skin photoaging model 1. FE increases cell proliferation and abrogates UVB irradiation-induced cell cycle arrest.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic applications of adipose cell-free derivatives: a review

et al. 2020

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Background: Adipose-derived stem cells (ADSCs) have become one of the most utilized adult stem cells due to their abundance and accessibility. Recent studies have shown that paracrine cytokines, exosomes, and other active substances are the main factors through which ADSCs exert their biological effects. Main body: Adipose cell-free derivatives have been recently gaining attention as potential therapeutic agents for various human diseases. These derivatives include ADSC-conditioned medium (ADSC-CM), ADSC exosomes (ADSC-Exo), and cell-free adipose tissue extracts (ATEs), all of which can be conveniently carried, stored, and transported. Currently, research on ADSC-conditioned medium (ADSC-CM) and ADSC exosomes (ADSC-Exo) is surging. Moreover, cell-free adipose tissue extracts (ATEs), obtained by purely physical methods, have emerged as the focus of research in recent years. Conclusion: Adipose cell-free derivatives delivery can promote cell proliferation, migration, and angiogenesis, suppress cell apoptosis, and inflammation, as well as reduce oxidative stress and immune regulation. Thus, adipose cell-free derivatives have a broad therapeutic potential in many areas, as they possess anti-skin aging properties, promote wound healing, reduce scar formation, and provide myocardial protection and neuroprotection. This article summarizes these effects and reviews research progress in the use of adipose cell-free derivatives.

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“…In addition, a previous study revealed that AST could prevent capillary regression in atrophied soleus muscles by upregulating vascular endothelial growth factor (VEGF) protein and downregulating thrombospondin-1 (TSP-1) protein in the soleus muscle of rats [45]. It has also been reported that reductions in the capillary diameter and volume are associated with vascular endothelial cell apoptosis via increased oxidative stress in hind limb unweighting of a rat model [46]. The data from the present study also indicate that the number of capillaries is markedly reduced after exposure to UV, whereas oral administration with AST prevented the decrease in capillaries in the skin of mice (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Matsumoto

Takuwa

et al. 2020

Biomedicines

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Ultraviolet (UV) light induces skin photoaging, which is characterized by thickening, wrinkling, pigmentation, and dryness. Astaxanthin (AST), a ketocarotenoid isolated from Haematococcus pluvialis, has been extensively studied owing to its possible effects on skin health as well as UV protection. In addition, AST attenuates the increased generation of reactive oxygen species (ROS) and capillary regression of the skeletal muscle. In this study, we investigated whether AST could protect against UV-induced photoaging and reduce capillary regression in the skin of HR-1 hairless mice. UV light induces wrinkle formation, epidermal thickening, and capillary regression in the dermis of HR-1 hairless mice. The administration of AST reduced the UV-induced wrinkle formation and skin thickening, and increased collagen fibers in the skin. AST supplementation also inhibited the generation of ROS, decreased wrinkle formation, reduced epidermal thickening, and increased the density of capillaries in the skin. We also found an inverse correlation between wrinkle formation and the density of capillaries. An association between photoaging and capillary regression in the skin was also observed. These results suggest that AST can protect against photoaging caused by UV irradiation and the inhibitory effects of AST on photoaging may be associated with the reduction of capillary regression in the skin.

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Protective Effect of Fat Extract on UVB-Induced Photoaging In Vitro and In Vivo

Cited by 48 publications

References 36 publications

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

Therapeutic applications of adipose cell-free derivatives: a review

Protective Effects of Astaxanthin Supplementation against Ultraviolet-Induced Photoaging in Hairless Mice

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