Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury

Choi, Jae Sue; Han, Yu Ran; Byeon, Jeong Su; Choung, Se‐Young; Sohn, Hee Sook; Jung, Hyun Ah

doi:10.1111/jphp.12404

Cited by 39 publications

(39 citation statements)

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“…This insightful paper outlines the approaches necessary for using VCD in the determination of absolute conguration. 537 The rst asymmetric synthesis of (À)-dolastatrienol (14-hydroxydolasta-1(15),7,9-triene) 538 was reported 539 along with a concise synthesis of dictyodendrins A and F. 540 Additionally, there were many papers and reviews dealing with the biological properties of brown algal polyphenolics [541][542][543][544][545][546][547][548][549][550][551][552][553][554][555][556][557] and carotenoids. 15,[558][559][560][561][562] 6 Red algae…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2017

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“…A similar study by Chen et al demonstrated that fucosterol isolated from S. fusiforme also enhanced the transactional activity of both LXR‐α and LXR‐β, indicating a selective LXR‐β agonist and a natural cholesterol‐lowering agent. Recently, Choi et al reported that hepatoprotective effect of fucosterol may be due to increase in the hepatic level of glutathione and inhibition of ROS generation as well as increase in the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). These findings suggest that fucosterol could be used for preventive therapies against oxidative stress‐related hepatotoxicity.…”

Section: Biological Effects Of Fucosterolmentioning

confidence: 99%

“…10 The total MeOH (70%) extract and partition fractions from Sargassum angustifolium, Chondria dasyphylla and Ulva flexuosa were evaluated against colon carcinoma (HT-29), colorectal adenocarcinoma (Caco-2), breast ductal carcinoma (T47D) and Swiss mouse embryo fibroblast (NIH 3 T3) cell lines by MTT assay. The hexane fraction from C. dasyphylla (IC 50 The genus Sargassum belongs to the brown algae of class Phaeophyceae, in the order Fucales. Several publications have confirmed that Sargassum metabolites have a wide range of biological activities, including antibiotic, anti-HIV, anticoagulant, anticonvulsant, anti-inflammatory, antineoplastic and antitumor properties.…”

Section: Anticancer Effectsmentioning

confidence: 99%

Health benefit of fucosterol from marine algae: a review

et al. 2016

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Seaweeds belong to a group of marine plants known as algae, which are consumed as sea vegetables in several Asian countries. Recent studies have focused on the biological and pharmacological activities of seaweeds and their highly bioactive secondary metabolites because of their potential in the development of new pharmaceutical agents. Although several varieties of bioactive novel compounds such as phlorotannins, diterpenes and polysaccharides from seaweeds have already been well scrutinized, fucosterol as a phytosterol still needs to reinvent itself. Fucosterol (24-ethylidene cholesterol) is a sterol that can be isolated from algae, seaweed and diatoms. Fucosterol exhibits various biological therapeutics, including anticancer, antidiabetic, antioxidant, hepatoprotective, antihyperlipidemic, antifungal, antihistaminic, anticholinergic, antiadipogenic, antiphotodamaging, anti-osteoporotic, blood cholesterol reducing, blood vessel thrombosis preventive and butyrylcholinesterase inhibitory activities. In this review, we address some potential approaches for arbitrating novel fucosterol biologics in the medical field, focusing on the selection of personalized drug candidates and highlighting the challenges and opportunities regarding medical breakthroughs. We also highlight recent advances made in the design of this novel compound, as the significant health benefits from using these optimized applications apply to the nutraceutical and pharmaceutical fields.

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“…Brown algae is a kind of macroalgae in the ocean. Fucosterol is a sort of algal phytosterol in ethanol extract of brown algae, which has been proved to have multiple biological activities, including antioxidant [14][15][16], anti-inflammatory [17][18][19], anticancer [20], antimicrobial [21], anti-depression [22], etc. Previous research have reported fucosterol on anti-cervical cancer [20], anti-leukemia [23], anti-colorectal cancer [24], etc., but there are few studies on the mechanisms of fucosterol in treating non-small cell lung cancer, and its potential therapeutic targets and related pathways have not been reported in detail.…”

Section: Introductionmentioning

confidence: 99%

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer Based on network pharmacology and molecular docking

Lin

et al. 2020

Preprint

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Background: It has been demonstrated that fucosterol induces a therapeutic effect on cancer. However, the molecular mechanisms underlying the effects of fucosterol in the treatment of non-small cell lung cancer are still unclear.Methods: In this study, pharmMapper and GeneCards databases were utilized to gather the prediction of fucosterol targets and NSCLC-related targets. The mechanisms of fucosterol against NSCLC were identified in DAVID6.8 by enrichment analysis of GO and KEGG, and protein-protein interaction data was obtained from Sting Database. Molecular docking was used to predict the docking of GRB2. Moreover, the relationship of GRB2 expression and immune infiltrates was analyzed by TIMER database.Results: The results suggest that fucosterol acts against by candidate targets, such as MAPK1, EGFR, GRB2, IGF2, MAPK8 and SRC, which regulate biological processes including negative regulation of apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation of cell proliferation. The Raf / MEK / ERK signaling pathway initiated by GRB2 maybe the most significant pathway for fucosterol to treat NSCLC.Conclusions: These results show that GRB2 is the key target for fucosterol in the treatment of NSCLC, which laying a theoretical foundation for further research and providing scientific support for the development of new drugs.

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Protective effect of fucosterol isolated from the edible brown algae, Ecklonia stolonifera and Eisenia bicyclis, on tert-butyl hydroperoxide- and tacrine-induced HepG2 cell injury

Abstract: These results suggest that fucosterol may be an effective hepatoprotective agent that could be useful for preventive therapies against oxidative stress-related hepatotoxicity.

Cited by 39 publications

References 48 publications

Marine natural products

Marine natural products

Health benefit of fucosterol from marine algae: a review

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer Based on network pharmacology and molecular docking

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