Protective Effect of Ginger Extract against Aspirin Induced Acute Gastric, Renal and Hepatic Damage in Rats

Abstract

The present study aimed to investigate the role of ginger in the prevention of aspirin-induced gastric and hepato-renal injury. Forty rats were distributed into 4 groups: normal control, aspirin, ginger control, and ginger plus aspirin. The normal control group was gavaged with saline for 7 days. The second group similarly treated with control except it was administered about 150 mg/kg aspirin on the 7 th day. The animal of third group was treated with ginger orally for 7 days. The forth group was similarly treated as the previous group except it was administrated aspirin on the 7 th day. The results of the biochemical analysis reported that ginger supplement preserved liver and kidney function serum markers close to normal. Also, histopathological findings demonstrated that pretreatment with ginger reversed aspirin-induced gastric, renal and hepatic tissues damage. Additionally, assessment of oxidative stress in tissues homogenates revealed that pretreatment with ginger attenuates significantly (p<0.001) lipid peroxidation marker malondialdehyde (MDA) and preserved the anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in the three investigated organs. It could be concluded that ginger pretreatment attenuates the aspirin-induced gastric and hepato-renal lesions via inhibiting the resultant oxidative stress.