Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using 18F-fuorodeoxyglucose

Deng, Liangliang; Wan, Haitong; Zhou, Huifen; Yu, Li

doi:10.1016/j.ejphar.2018.02.011

Cited by 34 publications

(47 citation statements)

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“…Normally, because glucose is the primary source of energy for brain cells, glucose metabolism also plays an important role in characterizing functional metabolism [15,16]. 18 Fluoro-2-deoxy-D-glucose ( 18 F-FDG) is widely used in different diseases as a common tracer and in the measurement of brain glucose metabolism. Recently, there has been tremendous interest in evaluating the potential of 18 F-FDG in cerebral ischaemia [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

“…18 Fluoro-2-deoxy-D-glucose ( 18 F-FDG) is widely used in different diseases as a common tracer and in the measurement of brain glucose metabolism. Recently, there has been tremendous interest in evaluating the potential of 18 F-FDG in cerebral ischaemia [17][18][19][20]. Deng et al also observed that 18 F-FDG uptake was higher in the cerebral infarction area among drug treatment groups in a rat model of cerebral ischaemia reperfusion injury evaluated after 7 days [18].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, there has been tremendous interest in evaluating the potential of 18 F-FDG in cerebral ischaemia [17][18][19][20]. Deng et al also observed that 18 F-FDG uptake was higher in the cerebral infarction area among drug treatment groups in a rat model of cerebral ischaemia reperfusion injury evaluated after 7 days [18]. Many previous studies have investigated perfusion and glucose metabolism using separate PET and MR procedures or integrated PET/MR in patients with cancer, Alzheimer's disease, epilepsy, and other disorders [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

“…18 F-FDG PET imaging shows promise as an indicator of the effectiveness of therapies in cerebral ischaemia [19]. Yoshida, K. et al combined measurements of CBF and cerebral glucose metabolism to evaluate cognitive changes after carotid endarterectomy [27], and Yu Z et al used 18 F-FDG PET/CT to evaluated 7 patients who underwent STA-MCA bypass surgery [28]. However, few studies have focused on combining measurements of CBF and 18 F-FDG uptake, especially using an integrated simultaneous PET/MR scanner, to evaluate patients after STA-MCA bypass surgery.…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease

Cui

Zhang

et al. 2019

Eur J Nucl Med Mol Imaging

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Purpose Cerebral blood flow (CBF) and glucose metabolism are important and significant factors in ischaemic cerebrovascular disease. The objective of this study was to use quantitative hybrid PET/MR to evaluate the effects of surgery treatment on the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease. Methods Fifteen patients diagnosed with ischaemic cerebrovascular disease were evaluated using a hybrid TOF PET/MR system (Signa, GE Healthcare). The CBF value measured by arterial spin labelling (ASL) and the standardized uptake value ratio (SUVR) measured by 18 F-FDG PET were obtained, except for the infarct area and its contralateral side, before and after bypass surgery. The asymmetry index (AI) was calculated from the CBF and SUVR of the ipsilateral and contralateral cerebral hemispheres, respectively. The ΔCBF and ΔSUVR were calculated as the percent changes of CBF and SUVR between before and after surgery, and paired t tests were used to determine whether a significant change occurred. Spearman's rank correlation was also used to compare CBF with glucose metabolism in the same region. Results The analysis primarily revealed that after bypass surgery, a statistically significant increase occurred in the CBF on the affected side (P < 0.01). The postprocedural SUVR was not significantly higher than the preprocedural SUVR (P > 0.05). However, the postprocedural AI values for CBF and SUVR were significantly lower after surgery than before surgery (P < 0.01). A significant correlation was found between the AI values for preoperative CBF and SUVR on the ipsilateral hemisphere (P < 0.01). Conclusions The present study demonstrates that a combination of ASL and 18 F-FDG PET could be used to simultaneously analyse changes in patients' cerebral haemodynamic patterns and metabolism between before and after superficial temporal artery-middle cerebral artery (STA-MCA) bypass surgery. This therefore represents an essential tool for the evaluation of critical haemodynamic and metabolic status in patients with symptomatic unilateral ischaemic cerebrovascular disease. Bixiao Cui and Tianhao Zhang contributed equally to this study. This article is part of the Topical Collection on Neurology.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease

Cui

Zhang

et al. 2019

Eur J Nucl Med Mol Imaging

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“…It was confirmed that SYA could protect neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro [34]. There have been a large number of studies showing the protective effects of HSYA on the cardiovascular system [35][36][37], nervous system [38,39], liver [40,41], lung [42,43], and others. It was also found to inhibit certain tumors [44,45] and has a certain impact on metabolism [46].…”

Section: Discussionmentioning

confidence: 85%

Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide

Wang

Guo

Wen

et al. 2020

Mediators of Inflammation

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Xuebijing injection is a Chinese herb compound to treat sepsis in China, but it contains many different kinds of components, and each component may have different effects in treating sepsis. The present study was performed to investigate the effect of three ingredients of Xuebijing, safflor yellow A (SYA), hydroxysafflor yellow A (HSYA), and anhydrosafflor yellow B (AHSYB), in lipopolysaccharide- (LPS-) induced acute lung injury (ALI). LPS (10 mg/kg) was injected intratracheally to induce acute lung injury in mice, which were then treated with SYA, HSYA, and AHSYB. The blood, bronchoalveolar lavage fluid (BALF), and lung tissues were collected to detect degree of lung injury, level of inflammation, and neutrophil extracellular traps (NETs). In vitro experiments were performed using HL-60 cells stimulated with phorbol myristate acetate (PMA). Lung injury induced by LPS was alleviated by SYA, HSYA, and AHSYB as demonstrated by the histopathologic test. The three components inhibit LPS-induced elevation of the levels of inflammatory factors and wet-to-dry weight ratio as well as the amount of protein and cells in the BALF. They also induced a remarkably less overlay of myeloperoxidase (MPO) and histone in the immunofluorescence assay and reduced level of MPO-DNA complex in plasma. The in vitro assay showed a similar trend that the three components inhibited PMA-induced NET release in neutrophil-like HL-60 cells. Western blot demonstrated that phosphorylation of c-rapidly accelerated fibrosarcoma (c-Raf), mitogen-activated protein kinase ERK kinase (MEK), and extracellular signal-regulated kinase (ERK) in the lungs of LPS-challenged mice, and PMA-treated HL-60 cells were all significantly reduced by SYA, HSYA, and AHSYB. Therefore, our data demonstrated that three components of XBJ, including SYA, HSYA, and AHSYB, showed a protective effect against LPS-induced lung injury and NET release.

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Cloning and expression analysis of HY5 transcription factor gene of safflower in response to light signal

Xian

Chen

Wang

et al. 2022

Biotech and App Biochem

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The flower of the safflower (Carthamus tinctorius L.) is a traditional Chinese medicine that can improve cerebral blood flow due to its enrichment in flavonoids. Light is one of the main environmental factors that affects safflower growth and flavonoid synthesis. Elongated hypocotyl 5 (HY5) plays an important role in plants’ light signal transduction. However, no study of HY5 in safflower has been conducted. In this study, a 462‐bp sequence of CtHY5 was successfully cloned. The expression pattern of CtHY5 in different safflower tissues and the expression patterns of CtHY5 and CtCHS1 in full‐blooming flowers that were treated under different light intensities were studied. The subcellular localization and the overexpression of CtHY5 were carried out as well. CtHY5 has a DNA‐binding region belonging to the basic leucine zipper transcription factor family. CtHY5 was specifically expressed in flowers. The expression level of CtHY5 first increased and then decreased with increasing light intensity, which was similar to the expression pattern of CtCHS1. The subcellular localization study was implemented in safflower protoplasts and the YFP fluorescence was observed in nucleus. The overexpression analysis initially verified the promotion effect of CtHY5 to the expression of CtCHS1 and the content of flavonoids.

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Protective effect of hydroxysafflor yellow A alone or in combination with acetylglutamine on cerebral ischemia reperfusion injury in rat: A PET study using 18F-fuorodeoxyglucose

Cited by 34 publications

References 46 publications

Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease

Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease

Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide

Cloning and expression analysis of HY5 transcription factor gene of safflower in response to light signal

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