Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Moshaei-Nezhad, Pedram; Hosseini, Seyed Mohammad; Yahyapour, Mohsen; Iman, Maryam; Khamesipour, Ali

doi:10.15171/jhp.2019.11

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…Additionally, renal functional indicators (urea, creatinine, and uric acid) in plasma and urine of diabetic nephrotoxic In rats are increased significantly (p≤ 0.05) (40). Because ivy leaves have a higher concentration of phytochemicals such flavones, phenolic compounds, Bglycan, and phytosterols, feeding them extract led to lower serum uric acid and creatinine levels (41). In comparison to the paracetamol group, treatment with ivy leaf extract significantly reduced serum concentrations of creatinine, uric acid, and BUN (42).…”

Section: Resultsmentioning

confidence: 95%

تأثير مستخلص أوراق اللبلاب على المؤشرات الحيويه للفئران المصابه بإرتفاع سكرالدم

عطى¹,

رجب²,

دياب³

2023

مجلة الاقتصاد المنزلي.جامعة المنوفية

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The problem of hyperglycemia has grown to be a significant obstacle for worldwide health issues. Drug resistance to treatments for diabetes and cytotoxicity have caused scientists worldwide to turn their attention from artificial to medicinal herbs. The current investigation aimed to find out how Ivy leaves extract affected the biological markers of diabetic rats. Thirty male adult albino rats (150 ±10 g) were used and divided into five groups (6 rats each). The first group was kept as a negative control group and was given the basal diet, but alloxan injections were given to the other four groups to cause hyperglycemia; the second group was given only a basal diet and served as a positive control group, which as the other three groups received a daily oral dose of ivy leaves extract 50, 100, and 150 mg/kg B.W. The results of treated rats showed a decrease in relative organ weight, liver enzymes, kidney function, serum glucose level, and lipid profile. At the same time, BWG, F.I., FER, and HDL-c were improved by rising compared to the positive control group when ivy leaf extract 50, 100, or 150 mg/kg B.W. was administered orally. The Ivy leaves extract had the best results when used at 150 mg/kg B.W. Conclusion These findings support the extract's traditional usage in the treatment of diabetes by indicating that it contains bioactive substances that can lower persistent hyperglycemia while avoiding complications.

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Section: Resultsmentioning

confidence: 95%

تأثير مستخلص أوراق اللبلاب على المؤشرات الحيويه للفئران المصابه بإرتفاع سكرالدم

عطى¹,

رجب²,

دياب³

2023

مجلة الاقتصاد المنزلي.جامعة المنوفية

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“…97 Furthermore, Moshaie-Nezhad et al proposed that CI extracts could prevent paracetamol-induced renal damage in mice, as significant reductions in blood urea nitrogen, creatinine, and uric acid levels were observed in the kidneys of treated mice. 98 Lastly, the flavonoid fraction of the ethanolic ivy extract would be a suitable candidate for treating rheumatoid arthritis (RA). The total ivy ethanolic extract and its isolated flavonoids fraction significantly (p-value <0.05) repressed the biochemical, pathological, and oxidative changes in rats caused by RA.…”

Section: ■ Physicochemical Properties Of CI Biomassmentioning

confidence: 99%

“…Hence, establishing their neuroprotective capabilities makes them interesting candidates to modulate Parkinson’s and Huntington’s disease . Furthermore, Moshaie-Nezhad et al proposed that CI extracts could prevent paracetamol-induced renal damage in mice, as significant reductions in blood urea nitrogen, creatinine, and uric acid levels were observed in the kidneys of treated mice . Lastly, the flavonoid fraction of the ethanolic ivy extract would be a suitable candidate for treating rheumatoid arthritis (RA).…”

Section: Common Ivy Extractives and Their Applicationsmentioning

confidence: 99%

Common Ivy (Hedera Helix L.) as a Novel Green Resource in an Urban Biorefinery Concept

Vercruysse,

Noppen,

Jozefczak

et al. 2023

ACS Sustainable Chem. Eng.

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Common ivy (CI) or Hedera Helix L., is a clinging evergreen vine that can be cultivated on any vertical surface (walls, fences, tree trunks, etc.). In Europe, CI has been recommended by governments to plant in urban areas because it lowers urban heat island effects and improves urban air quality. Regular trimmings of these vertical greenery systems would be necessary, which would yield a potentially interesting novel biomass resource for urban biorefinery concepts. Furthermore, CI extracts contain pharmaceutically active compounds (e.g., hederacoside C and α-hederin), which constitute the active components of commercially available cough syrups. Moreover, research on their suitability to treat (lung) inflammations and suppress cancer tumor growth is ongoing and shows promise. CI extracts also have demonstrated potential for their application in the agricultural industry to serve as antifungal agents. Recently, postextracted residues of CI have shown to be a promising feedstock for green fertilizer production via slow pyrolysis. Moreover, a provisional sustainability assessment indicated that the proposed process would be both carbon-and energy-negative. Therefore, a novel circular biorefinery approach is proposed, which entails the lifecycle of CI, from cultivation in vertical ecosystems via refinery into bioproduct(s) and valuable nutrients, and then back into soil.

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“…Many studies have also reported increased levels of creatinine and blood urea nitrogen (BUN) after APAP toxicity [25][26][27]. These outcomes are potential indicators of nephrotoxicity.…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats

Hammad

Shawaqfeh

Hikmat

et al. 2023

Toxics

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Paracetamol (acetaminophen, APAP) is the most common non-prescription analgesic drug used during pregnancy. The aim of this study was to investigate the effect of vitamin E on acute APAP toxicity in pregnant rats. Toxicity in the liver, kidney, and brain (hippocampus, cerebellum, and olfactory bulb) was examined. Twenty pregnant female Wistar rats at gestational day 18 were used. Pregnant rats were divided into four groups: Control, APAP, E + APAP, and APAP + E. The Control group was treated with 0.5 mL p.o. corn oil. The APAP group received 3000 mg/kg p.o. APAP. The E + APAP group received 300 mg/kg p.o. vitamin E one hour before 3000 mg/kg APAP. The APAP + E group received 3000 mg/kg paracetamol one hour before 300 mg/kg p.o. vitamin E. Twenty-four hours after the last treatment administration, rats were euthanized and blood, brain, liver, and kidney samples were collected. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), creatinine levels, uric acid (UA), and superoxide dismutase (SOD) levels, as well as the relative mRNA expression of Cyp1a4, Cyp2d6, and Nat2, were determined. Acute APAP treatment upregulated ALT, AST, BUN, and creatinine levels. APAP treatment downregulated UA and SOD levels. APAP treatment upregulated the relative mRNA expression of Cyp1a4 and Cyp2d6, but downregulated Nat2 expression. Vitamin E treatment, either before or after APAP administration, attenuated the toxic effects of APAP. In conclusion, the results showed that an acute toxic APAP dose in late pregnancy can cause oxidative stress and dysregulation in Cyp isoform expression, and that vitamin E treatment attenuates these effects.

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Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Abstract: Results demonstrate that ivy leaf extract might be used to prevent renal damage induced by paracetamol. This is a promising result for preparation of new drugs. Further studies are required to confirm the mechanisms responsible for nephron-protective activity.

Cited by 5 publications

References 20 publications

تأثير مستخلص أوراق اللبلاب على المؤشرات الحيويه للفئران المصابه بإرتفاع سكرالدم

تأثير مستخلص أوراق اللبلاب على المؤشرات الحيويه للفئران المصابه بإرتفاع سكرالدم

Common Ivy (Hedera Helix L.) as a Novel Green Resource in an Urban Biorefinery Concept

The Role of Vitamin E in Protecting against Oxidative Stress, Inflammation, and the Neurotoxic Effects of Acute Paracetamol in Pregnant Female Rats

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