Protective effect of lanostane triterpenoids from the sclerotia of Poria cocos Wolf against cisplatin-induced apoptosis in LLC-PK1 cells

Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/Axl NF κB/Nrf2 axis

“…Our latest studies demonstrated that several poricoic acids could protect against renal fibrosis by inhibiting RAS activation and TGF-β/Smad and Wnt/β-catenin pathways in both in vitro and in vivo experiments [48][49][50]. Another study demonstrated that dehydroeburicoic acid monoacetate isolated from Poria cocos could inhibit cisplatin-induced nephrotoxicity by inhibiting the upregulated expression of phosphorylation of the mitogen-activated protein kinase, c-Jun N-terminal kinase, extracellular signal-regulated kinase, and p38 and caspase-3 in the kidney proximal tubule cells (LLC-PK1) [51]. Due to the similar chemical structures among these components isolated from P. cocos, these previous studies supported renoprotective effect of PAA by retarding AKI-to-CKD transition.…”

Novel inhibitors of the cellular renin‐angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β‐catenin pathway against renal fibrosis

“…A number of studies have demonstrated the renoprotective effect of P. cocos (Lee et al, ; Yoon et al, ; Lee et al, ). In addition, several studies have shown the protective effect of lanostane triterpenoids derived from the sclerotia of P. cocos on renal tubular epithelial cells including LLC‐PK1 and HK‐2 cells (Lee et al, ; Wang et al, ). In this study, we demonstrated for the first time that three novel RAS inhibitors including PZC, PZD and PZE, as tetracyclic triterpenoid compounds extracted and isolated from SLPC, significantly attenuated TIF by blocking the Wnt/β‐catenin and TGF‐β/Smad signalling cascades in vitro and in vivo (Figure ).…”

Development of a systematic strategy for the global identification and classification of the chemical constituents and metabolites of Kai‐Xin‐San based on liquid chromatography with quadrupole time‐of‐flight mass spectrometry combined with multiple data‐processing approaches

“…The substances mentioned above played a synergistic effect in KXS traditional Chinese medicine prescription. Beyond that, few components detected in brain, including small triterpene acids in Poria, phenylpropanoids in Acori Tatarinowii Rhizoma, and triterpene acids have also been reported to possess protective effects against apoptosis except the biological activities mentioned above. Some phenylpropanoids with phenolic acids structure showed significant O 2 •– scavenging capacity as well, which may be attributed to the 3‐hydroxy group or 3,4‐dihydroxy moiety on the phenyl ring .…”