Protective effect of modified glucomannans and organic selenium against antioxidant depletion in the chicken liver due to T-2 toxin-contaminated feed consumption

Dvorska, J. E.; Pappas, Athanasıos C.; Karadaş, Filiz; Speake, Brian K.; Surai, Peter F.

doi:10.1016/j.cbpc.2007.02.005

Cited by 61 publications

(46 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…TBARS content, as end-product of lipid peroxidation, did not change significantly at the lower level (1.5 mg/kg feed) of T-2 toxin contamination, and also not in the liver at both (1.5 or 3.4 mg/kg feed) contamination levels. This result may be explaining those previous results where significant differences in TBARS concentration in the liver were found only at higher dose of exposure (Dvorska et al, 2007). This may cause by the activation of antioxidant defense after T-2 toxin exposure, which eliminate oxygen free radicals effectively.…”

Section: Discussionsupporting

confidence: 73%

“…However, results published on the effects of T-2 toxin on lipid peroxidation are contradictious. T-2 toxin-induced oxidative stress was found in vitro in chondrocytes (He et al, 2012) and in human cervical cancer cells (Chaudhari et al, 2009a) and in vivo in mice (Chaudhari et al, 2009b), rats (Rizzo et al, 1994;Rocha et al, 2005) and broiler chickens (Mézes et al, 1998;Dvorska et al, 2007) in a dose dependent manner. Most of the previous studies also revealed that T-2 toxin has marked effect on the antioxidant status of animals (Atroshi et al, 2002, Surai, 2002 because of its pro-oxidant properties (Rizzo et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens

et al. 2015

View full text Add to dashboard Cite

The effect of two different contamination levels of T-2 toxin (1.5 or 3.4 mg/kg feed) was investigated in a 28-days feeding trial on body weight, relative weight of liver and spleen, and some lipid peroxidation and glutathione redox parameters of 14-days old broiler chicken. The results showed that T-2 toxin decreased significantly the body weight at both contamination levels and showed a dose-dependent tendency. Relative weight of liver increased till the end of the trial, while relative weight of spleen was lower at both samplings at lower level of T-2 toxin exposure. Initial phase of lipid peroxidation (conjugated dienes and trienes) was not detected in the liver, but as product of later phase, thiobarbituric acid reactive substances increased significantly, except in the liver. Glutathione content on day 14 was higher in liver homogenate as compared to the control at the lower T-2 toxin contamination level. On day 28 it was higher in blood plasma at the higher and in liver homogenate at both levels of T-2 contamination. Glutathione peroxidase activity on day 14 was significantly higher in liver and spleen homogenates as compared to the control at the lower level of T-2 toxin contamination. On day 28, significantly higher activity was found at both T-2 toxin contamination levels in liver homogenate, and at the lower contamination level in spleen homogenate as compared to the control.The results revealed that T-2 toxin exposure initiates lipid peroxidation and activates the glutathione redox system as well, but the changes were irrespective of the dose-and partly duration of the exposure.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Recently, the use of yeast has become increasingly popular to prevent mycotoxicoses caused by OTA, aflatoxins, and some Fusarium mycotoxins (Raju and Devegowda 2000;Yiannikouris et al 2004;Karaman et al 2005;PfohlLeszkowicz and Manderville 2007;Dvorska et al 2007;Pfohl-Leszkowicz et al 2015). Therefore, the present study was designed to test the efficacy of a modified yeast cell wall extract (mYCW; Alltech Inc., KY) for preventing the toxic effects of PMs using an in vitro BoMac proliferation assay.…”

Section: Introductionmentioning

confidence: 98%

In vitro exposure of Penicillium mycotoxins with or without a modified yeast cell wall extract (mYCW) on bovine macrophages (BoMacs)

Quinton

Boermans

et al. 2015

Mycotoxin Res

View full text Add to dashboard Cite

Penicillium mycotoxins (PMs) are contaminants that are frequently found in grain or crop-based silage for animal feed. Previously, we have characterized the potential immunotoxicity of the following PMs: citrinin (CIT), ochratoxin A (OTA), patulin (PAT), mycophenolic acid (MPA), and penicillic acid (PA) by using a bovine macrophage cell line (BoMacs). In the present study, cell proliferation was used as a bioassay endpoint to evaluate the efficacy of a modified yeast cell wall extract (mYCW), for preventing PM toxicity under various in vitro conditions such as the following: pH (3, 5, 7), incubation time (1, 2, 4, 6 h), percentage of mYCW (0.05, 0.1, 0.2, 0.5, 1.0 %), and PM concentration. mYCW was most effective in preventing the toxicity of 12.88 and 25.8 μM OTA at pH 3.0 (p < 0.0001), regardless of incubation time (p < 0.0001) and the percentage of mYCW (p < 0.0001). An incubation time of 6 h (p < 0.05) or 0.5 and 1.0 % mYCW (p < 0.0001) significantly improved the efficacy of mYCW for preventing CIT toxicity. In contrast, 0.5 and 1.0 % of mYCW appeared to exacerbate the PAT toxicity (p < 0. 0001). This effect on PAT toxicity was constantly observed with higher PAT concentrations, and it reached significance at a concentration of 0.70 μM (p < 0.0001). mYCW had no effect on PA toxicity. These results suggest that mYCW may reduce OTA toxicity and, to some extent, CIT toxicity at pH 3.0. Although PAT toxicity was increased by mYCW treatment, PAT is readily degraded during heat treatment and may therefore be dealt with using other preventative measures.

show abstract

“…YS, a natural organic product that has been shown to have a mostly selenomethionine source of selenium [10], has been used in numerous nutritional studies [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Use of Stringent Selection Parameters for the Identification of Possible Selenium-Responsive Marker Genes in Mouse Liver and Gastrocnemius

Mallonee

Crowdus

Barger³

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

Selenium is a trace element that, although toxic in higher concentrations, is essential for human and animal health. In this study, we looked at microarray-based gene expression patterns from liver and gastrocnemius tissues in mice fed either a selenium-deficient diet or diets containing sodium selenite, selenomethionine, or a yeast-derived selenium supplement. A p value cutoff of 0.01 was used to identify a select set of selenium-responsive genes that were consistently differentially expressed across three age groups of mice with both ANOVA and t test analyses. A total of 19 gene transcripts were found to be differentially expressed across the three age groups with at least one selenium-deficient/selenium-supplemented diet comparison. Of those 19 genes, 12 had been previously identified as selenoprotein-encoding genes, and four of the genes, Gpx1, Selh, Sep15, and Sepw1, were differentially expressed in both tissues, all three mouse age groups, and all three diet comparisons. Activities associated with non-selenoproteins encoded by selenium-responsive genes included transport and stress response. The selenophosphate synthetase 2 gene Sephs2 in gastrocnemius tissue and the solute carrier gene Slc48a1 in liver tissue, both up-regulated with selenium-deficient diets compared to all three selenium-supplemented diets, are previously overlooked candidates for dietary selenium marker genes.

show abstract

Protective effect of modified glucomannans and organic selenium against antioxidant depletion in the chicken liver due to T-2 toxin-contaminated feed consumption

Cited by 61 publications

References 38 publications

Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens

Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens

In vitro exposure of Penicillium mycotoxins with or without a modified yeast cell wall extract (mYCW) on bovine macrophages (BoMacs)

Use of Stringent Selection Parameters for the Identification of Possible Selenium-Responsive Marker Genes in Mouse Liver and Gastrocnemius

Contact Info

Product

Resources

About