Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis

Zhao, Jing; Hong, Tian; Dong, Min; Meng, Yixiao; Mu, Jiaye

doi:10.3892/mmr.2012.1225

Cited by 64 publications

(44 citation statements)

References 24 publications

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“…This indicated that DSS administration damaged the antioxidative ability, which may subsequently cause the onset of colitis onset. This is consistent with previous reports (26,27). In the present study, UA treatment for 7 days significantly improved the increased MDA content and decreased SOD activity in the colon tissues.…”

Section: Discussionsupporting

confidence: 82%

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Liu

Piao

Guo

et al. 2016

Molecular Medicine Reports

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Abstract. Ursolic acid (UA) has been reported to have a protective effect in colitis. However, the underlying mechanisms remain to be elucidated. In the present study, experimental ulcerative colitis was induced in male BALB/c mice by the administration of 5% dextran sulfate sodium (DSS) for 7 days, followed by treatment with UA for another 7 days. Hematoxylin & eosin staining was performed to evaluate colon tissue damage, and enzyme assays were used to measure malondialdehyde (MDA) content and superoxide dismutase (SOD) activity in colon homogenate. In addition, serum levels of interleukin (IL)-1β and tumor necrosis factor (TNF)-α were measured using an ELISA, and the level of nuclear factor (NF)-κB p65 in the colonic tissues was assessed by western blotting. The 7-day DSS administration induced marked colon damage, increased the serum levels of IL-1β and TNF-α, increased MDA content and decreased SOD activity in the colon homogenate. These changes were significantly improved by treatment with UA. UA also reduced the DSS-stimulated high nuclear level of NF-κB p65 in the colon tissues. These results demonstrate a protective role of UA in ulcerative colitis, and suggest that anti-inflammatory and antioxidant activities are involved in the underlying mechanisms.

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Section: Discussionsupporting

confidence: 82%

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Liu

Piao

Guo

et al. 2016

Molecular Medicine Reports

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“…In fact, colitic mice treated with vehicle exhibited increased LOOH content and this change was accompanied by reduction in GSH levels, a nonenzymatic antioxidant defense. In addition, similarly to Zhao et al [48], the SOD activity was reduced in colon tissue from colitic mice treated with vehicle. SOD is metal ion cofactor-requiring enzymes that catalyze dismutation of superoxide anion (O 2 •− ) into molecular oxygen (O 2 ) and hydrogen peroxide (H 2 O 2 ) [47].…”

Section: Discussionsupporting

confidence: 76%

Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium‐Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators

Silva

Farias

Boeing

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Achyrocline satureioides is a South American herb used to treat inflammatory and gastrointestinal diseases. This study evaluated intestinal anti-inflammatory effects of the hydroalcoholic extract of inflorescences of satureioides (HEAS) in dextran sulfate sodium (DSS) induced colitis in mice. Mice were orally treated with vehicle, 5-aminosalicylic acid (100 mg/kg), or HEAS (1–100 mg/kg). Clinical signs of colitis and colonic histopathological parameters were evaluated, along with the determination of levels of reduced glutathione and lipid hydroperoxide (LOOH), the superoxide dismutase (SOD), and myeloperoxidase (MPO) activity in colon. The colonic content of cytokines (TNF, IL-4, IL-6, and IL-10) was measured. Additionally, the effects of the extract on nitric oxide (NO) release by lipopolysaccharide (LPS) stimulated macrophages and diphenylpicrylhydrazyl levels were determined. Mucin levels and SOD activity, as well as the LOOH, MPO, TNF, and IL-6 accumulation in colon tissues, were normalized by the HEAS administration. In addition, the extract elicited an increase in IL-4 and IL-10 levels in colon. NO release by macrophages was inhibited by HEAS and its scavenger activity was confirmed. Together these results suggest that preparations obtained from inflorescences from A. satureioides could be used in treatment for IBD. Besides, this work corroborates the popular use of A. satureioides in inflammatory disorders.

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“…These results were supported by some other natural extracts such as mangiferin 30 and myricetin, 34 which were all proven to be effective in preventing colitis as well as decreasing the MPO activity and MDA and NO contents. Since DSS-induced mice developed immunological abnormalities, such as prominent inflammatory cell infiltration in the lamina propria of the colon, thickening of the muscular layer and crypt damage in the inflamed areas and extensive infiltration of leukocytes in the mucosa.…”

Section: Discussionmentioning

confidence: 66%

Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice

et al. 2015

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Ulcerative colitis is a major inflammatory bowel disease (IBD), characterized by inflammation within the gastrointestinal tract through chronic or relapsing immune system activation. The aim of this study is to investigate the potential protective effect of oat β-glucan (βG) against colitis induced by DSS in mice. Eighty mice were randomly divided into the control group (no DSS, no βG), DSS group (DSS only), DSS + L-βG group (DSS plus 500 mg per kg βG), and DSS + H-βG group (DSS plus 1000 mg per kg βG). Compared with the DSS group, administration of βG significantly reduced clinical symptoms with less weight loss, diarrhea and shortening of the colon, the severity of colitis was significantly inhibited as evidenced by the reduced disease activity index (DAI) and degree of histological damage in colon. Moreover, treatment with βG not only decreased myeloperoxidase activity (MPO), and nitric oxide (NO) and malondialdehyde (MDA) levels, but also inhibited mRNA and protein expression of pro-inflammatory factors such as TNF-α, IL-1β, IL-6 and iNOS. This suggests that oat βG in diet might exhibit an anti-inflammatory function against colitis through inhibition of expression of pro-inflammatory factors.

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Protective effect of myricetin in dextran sulphate sodium-induced murine ulcerative colitis

Cited by 64 publications

References 24 publications

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Ursolic acid protects against ulcerative colitis via anti-inflammatory and antioxidant effects in mice

Hydroalcoholic Extract from Inflorescences of Achyrocline satureioides (Compositae) Ameliorates Dextran Sulphate Sodium‐Induced Colitis in Mice by Attenuation in the Production of Inflammatory Cytokines and Oxidative Mediators

Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice

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