Protective effect of n-3 polyunsaturated fatty acids concentrate on isoproterenol-induced myocardial infarction in rats

Anandan, R.; Mathew, Suseela; Sankar, T.V.; Nair, P.G.V.

doi:10.1016/j.plefa.2006.12.002

Cited by 44 publications

(37 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ISO-induced MI is associated with enhanced levels of circulatory lipids. It has been reported that the increased myocardial cholesterol content in ISO-induced rats is due to increased uptake of LDL-cholesterol from the blood by myocardial membranes [26]. Oral pretreatment with vanillic acid decreased the levels of total cholesterol in the serum and heart of myocardial infarcted rats.…”

Section: Discussionmentioning

confidence: 94%

Preventive Effects of Vanillic Acid on Lipids, Bax, Bcl-2 and Myocardial Infarct Size on Isoproterenol-Induced Myocardial Infarcted Rats: A Biochemical and In Vitro Study

2010

View full text Add to dashboard Cite

We made an attempt to evaluate the preventive effects of vanillic acid on isoproterenol-induced myocardial infarcted rats. Rats were pretreated with vanillic acid (5 and 10 mg/kg) daily for 10 days. After pretreatment, rats were injected with isoproterenol (100 mg/kg) at an interval of 24 h for 2 days to induce myocardial infarction. Isoproterenol induction increased the activity of serum creatine kinase-MB and increased the levels of serum and heart cholesterol, triglycerides, free fatty acids in rats. It increased the levels of serum low density and very low density lipoprotein cholesterol and decreased the levels of high-density lipoprotein cholesterol. Also, the activity of 3-hydroxy-3methyl glutaryl-coenzyme-A-reductase in the plasma and liver was increased, and lecithin cholesterol acyl transferase activity in the plasma and liver was decreased in isoproterenol-induced rats. Furthermore, isoproterenol-induced rats showed a decrease in myocardial expression of B-cell leukemia/lymphoma-2(bcl-2) gene and an increase in myocardial expression of bcl-2 associated-x (bax)-gene. Vanillic acid pretreated isoproterenol-induced rats positively altered all the above-mentioned biochemical parameters. Vanillic acid pretreatment also reduced myocardial infarct size in myocardial infarcted rats. In vitro study confirmed the potent free radical scavenging effect of vanillic acid. The observed effects are due to free radical scavenging effects of vanillic acid. This study may have a significant impact on myocardial infarcted patients.

show abstract

Section: Discussionmentioning

confidence: 94%

Preventive Effects of Vanillic Acid on Lipids, Bax, Bcl-2 and Myocardial Infarct Size on Isoproterenol-Induced Myocardial Infarcted Rats: A Biochemical and In Vitro Study

2010

View full text Add to dashboard Cite

show abstract

“…The reason for the increase in LDL in blood is due to the hyperlipidemia caused by ISO, which in turn leads to the buildup of harmful deposits in the arteries thus favoring coronary heart diseases (CHD) (Rajadurai and Prince Rajadurai and Stanely Mainzen Prince 2006 administration also increases the uptake of LDL from the blood by myocardial membranes thus increasing the myocardial cholesterol levels (Anandan et al 2007). …”

Section: Discussionmentioning

confidence: 99%

Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats

Lobo

Shenoy

2014

J Food Sci Technol

View full text Add to dashboard Cite

Kombucha (Bio-tea) is a beverage produced by the fermentation of sugared black tea using a symbiotic association of bacteria and yeasts. Traditional claims about Kombucha report beneficial effects such as antibiotic properties, gastric regulation, relief from joint rheumatism and positive influence on the cholesterol level, arteriosclerosis, diabetes, and aging problems. The present investigation was carried out to understand the preventive effect of Kombucha on heart weight, blood glucose, total protein, lipid profile and cardiac markers in rats with myocardial damage induced using Isoproterenol. As Bio-tea is produced by fermenting tea, the parameters were compared in rats pre-treated with normal black tea and Bio-tea for 30 days followed by subcutaneous injection of Isoproterenol (85 mg/kg body weight). Normal rats as well as Isoproterenol induced myocardial infarcted rats were also used, which served as controls. Isoproterenol induced myocardial infarcted control rats showed a significant increase in heart weight, blood glucose and cardiac markers and a decrease in plasma protein. Increased levels of cholesterol, triglycerides, low density lipids (LDL) and very low density lipids (VLDL) were also observed, while the high density lipid (HDL) content decreased. Bio-tea showed a higher preventive effect against myocardial infarction when compared to tea, as was observed by the significant reduction in heart weight, and blood glucose and increase in plasma albumin levels. Bio-tea significantly decreased cholesterol, triglycerides, LDL and VLDL while simultaneously increasing the levels of HDL. Similarly a decrease in leakage of cardiac markers from the myocardium was also observed.

show abstract

“…As a result of these metabolic events, peroxidation reactions are accelerated leading to cellular injury [25]. Anandan et al [26] have reported that the increase in the myocardial cholesterol content in ISO-induced rats is due to increased uptake of LDL-cholesterol from the blood by myocardial membranes. The oral administration of EGCG (30 mg/kg) decreased the levels of cholesterol in myocardial-infarcted rats.…”

Section: Discussionmentioning

confidence: 99%

Preventive effect of (−)epigallocatechin gallate on lipids, lipoproteins, and enzymes of lipid metabolism in isoproterenol‐induced myocardial infarction in rats

Prince

2009

J Biochem & Molecular Tox

View full text Add to dashboard Cite

This article reports data on the preventive effect of (-)epigallocatechin gallate (EGCG) on lipid metabolism and lipoproteins in isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats. The rats were induced MI by ISO (100 mg/kg) at an interval of 24 h for 2 days. EGCG (30 mg/kg) was given to rats as pretreatment for 21 days orally using an intragastric tube. EGCG significantly reduced the increased serum levels of cholesterol, triglycerides, and free fatty acids in the heart and serum phospholipids (PLs) in ISO-treated rats. It also significantly increased the reduced levels of heart PLs in ISO-induced rats. EGCG reduced the levels of serum low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol and increased serum high-density lipoprotein (HDL)-cholesterol in ISO-treated rats. It also reduced the increased cholesterol/PL ratio and atherogenic index and significantly increased the reduced ratio of HDL-cholesterol/total cholesterol. Also EGCG significantly increased the reduced activity of lecithin cholesterol acyl transferase in ISO-treated rats. Thus, EGCG prevented the accumulation of lipids and altered the levels of lipoproteins in myocardial-infarcted rats.

show abstract

Protective effect of n-3 polyunsaturated fatty acids concentrate on isoproterenol-induced myocardial infarction in rats

Cited by 44 publications

References 31 publications

Preventive Effects of Vanillic Acid on Lipids, Bax, Bcl-2 and Myocardial Infarct Size on Isoproterenol-Induced Myocardial Infarcted Rats: A Biochemical and In Vitro Study

Preventive Effects of Vanillic Acid on Lipids, Bax, Bcl-2 and Myocardial Infarct Size on Isoproterenol-Induced Myocardial Infarcted Rats: A Biochemical and In Vitro Study

Myocardial potency of Bio-tea against Isoproterenol induced myocardial damage in rats

Preventive effect of (−)epigallocatechin gallate on lipids, lipoproteins, and enzymes of lipid metabolism in isoproterenol‐induced myocardial infarction in rats

Contact Info

Product

Resources

About