Protective effect of ocotillol against doxorubicin-induced acute and chronic cardiac injury

Abstract

Abstract. Doxorubicin (Dox) has been clinically observed to exert marked anticancer activity. However, it is severely restricted by its associated dose-dependent cardiotoxicity, which may be attenuated by decreasing the cumulative dosage via combining with a non-toxic 'sensitizer'. We previously reported that ocotillol is capable of enhancing the antitumor activity of Dox; however, the effects of ocotillol on its cardiotoxicity remain unclear. In the current study, the effects of ocotillol on the toxicity of Dox were investigated, particularly its role in cardiotoxicity. In the acute injury model, pre-administration of ocotillol prolonged the survival time. In the chronic animal model, pre-administration of ocotillol decreased the elevated levels of plasma creatine kinase (CK) and CK-MB, as well as attenuated the pathological changes that occurred. Pre-treatment with ocotillol ameliorated the decreased glutathione level and reduced the cumulated malondialdehyde in the heart tissue. In addition, pre-treatment with ocotillol restored the lowered white blood cell count. The results indicate that Dox co-treatment with ocotillol may effectively alleviate its associated toxic injury, particularly cardiotoxicity. Thus, co-administration of Dox with ocotillol may be a potential therapeutic strategy.

The pseudoginsenoside F11 ameliorates cisplatin-induced nephrotoxicity without compromising its anti-tumor activity in vivo

“…There were substantial evidences to show that ginseng had a wide range of pharmacological actions, including neuroprotective, cardioprotective, antioxidant and anticancer properties, in which the active ingredient were primarily thought to the ginsenosides14. Recently, we reported that Rh2 and ocotillol, two ingredients in the gingeng, attenuated doxorubicin-induced cardiotoxicology via their antioxidant capabilities1617. Here we reported that F1118, one pseudoginsenoside, attenuated the nephrotoxicity induced by CDDP without affecting its anti-tumor efficacy.…”

Cardioprotective Potentials of Plant‐Derived Small Molecules against Doxorubicin Associated Cardiotoxicity

“…Ocotillol prevented depletion of glutathione and lipid peroxidation along with restoration of myocyte injury marker enzymes following preservation of cardiomyocytes cell membrane. Furthermore, ocotillol also improved cardiac function and hence was suggested as an adjuvant for counteracting DOX-induced cardiotoxicity [ 86 ].…”

Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice

“…18,28,29 The administration of Dox has been shown to cause toxicity and the depletion of leukocytes. 31,32 The results of the present study showed that free Dox induces both quantitative and qualitative changes in the leukocytes. The group of mice treated with free Dox exhibited a substantial reduction in leukocyte count compared to the groups injected with Lip-Dox or a combination of Lip-Dox and glycosphingosomes.…”