Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

Gao, Wei; Li, Haiying; Wang, Lixin; Lü, Hao; Jian-li, Gao; Ruan, Zheng; Cai, Chunjiang; Si, Yiming

doi:10.1016/s1995-7645(14)60065-1

Cited by 15 publications

(11 citation statements)

References 21 publications

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“…There are reports of in vivo studies, in which OME had effects over increased blood flow of the gastric mucosa and PPIs: proton pump inhibitors; TNF-α: tumor necrosis factor-alpha. 6 Oxidative Medicine and Cellular Longevity expression of gastric glycoproteins [69] that is used as a precise and sensitive marker for the gastric mucosal status. Moreover, OME also plays a significant role as an antiacid, pepsin-resistant, and ulceration protector, which helps to protect the mucosal integrity [81] and reduces neutrophil infiltration [69].…”

Section: Antioxidant and Anti-inflammatory Effects Several In Vivo Smentioning

confidence: 99%

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

Paz

Alencar

Lima

et al. 2020

Oxidative Medicine and Cellular Longevity

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Omeprazole (OME) is commonly used to treat gastrointestinal disorders. However, long-term use of OME can increase the risk of gastric cancer. We aimed to characterize the pharmacological effects of OME and to correlate its adverse effects and toxicogenetic risks to the genomic instability mechanisms and cancer-based on database reports. Thus, a search (till Aug 2019) was made in the PubMed, Scopus, and ScienceDirect with relevant keywords. Based on the study objective, we included 80 clinical reports, forty-six in vitro, and 76 in vivo studies. While controversial, the findings suggest that long-term use of OME (5 to 40 mg/kg) can induce genomic instability. On the other hand, OME-mediated protective effects are well reported and related to proton pump blockade and anti-inflammatory activity through an increase in gastric flow, anti-inflammatory markers (COX-2 and interleukins) and antiapoptotic markers (caspases and BCL-2), glycoprotein expression, and neutrophil infiltration reduction. The reported adverse and toxic effects, especially in clinical studies, were atrophic gastritis, cobalamin deficiencies, homeostasis disorders, polyp development, hepatotoxicity, cytotoxicity, and genotoxicity. This study highlights that OME may induce genomic instability and increase the risk of certain types of cancer. Therefore, adequate precautions should be taken, especially in its long-term therapeutic strategies and self-medication practices.

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Section: Antioxidant and Anti-inflammatory Effects Several In Vivo Smentioning

confidence: 99%

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

Paz

Alencar

Lima

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Numerous types of animal models of portal hypertension are currently available, including the following: i) Drug induced models, in which carbon tetrachloride ( 8 ), thioacetamide ( 9 ) or dimethylnitrosamine ( 10 ) is used to induce liver injury. Although prominent cirrhosis and portal hypertension are present in these models, portal-systemic collateral circulation is not evident, and longer time periods of induction may be required (11–15 weeks).…”

Section: Discussionmentioning

confidence: 99%

Establishment of a reversible model of prehepatic portal hypertension in rats

Zhao

Dou

Gao

2016

Experimental and Therapeutic Medicine

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The aim of the present study was to improve upon the traditional model of pre-hepatic portal hypertension in rats, and simulate the anhepatic phase of orthotopic liver transplantation without veno-venous bypass. A reversible model of portal hypertension was induced by portal vein ligation, with a label ring ligated along the portal vein. A total of 135 male Wistar rats were divided into three groups: i) Normal control (NC) group; ii) portal hypertensive control (PHTC) group; and iii) reperfusion (R) group. In the R group, rats with portal hypertension underwent simultaneous clamping of the portal triad and retrohepatic vena cava for 1 h, followed by removal of the clamps to enable blood reperfusion. Portal venography and portal vein pressure were recorded during the surgery. Arterial oxygen pressure (PaO2), and alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) levels were determined, and pathological changes of the liver were investigated by immunohistochemical staining. The results demonstrated that, 3 weeks after portal vein ligation, the vein area and the free portal pressures in the PHTC group were significantly increased compared with those in the NC group. The serum ALT and AST levels in the R group at different time points were significantly elevated compared with those in the PHTC group, and reached their maximal levels at 24 h after reperfusion. Furthermore, the PaO2 at 24 h after reperfusion was significantly decreased. In conclusion, the reversible model of pre-hepatic portal hypertension in rats was successfully established using the introduction of a label ring. This model may be useful for basic research focusing on the anhepatic phase of orthotopic liver transplantation without veno-venous bypass.

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“…To understand the protective effect of gastric mucosal region, this study (131) studied the effects on rats. The authors suggest that omeprazole plays a protective role in the gastric mucosa by improving the gastric environment, by reducing the damage to the gastric mucosa through the influence of inflammatory cytokines.…”

Section: Microbiota-related Treatments In Liver Diseasementioning

confidence: 99%

Gut microbiome and liver disease

Betrapally

Gillevet

Bajaj

2017

Translational Research

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Gut microbiota changes are important in determining the occurrence and progression of chronic liver disease related to alcohol, non-alcoholic fatty liver disease and cirrhosis. Specifically the systemic inflammation, endotoxemia and the vasodilation that leads to complications such as spontaneous bacterial peritonitis and hepatic encephalopathy could be related to the gut milieu. Given the poor prognosis of these events, their prevention and early management are essential. Microbiota may be essential component of the gut milieu that can impact these clinical events and the study of their composition and function in a culture-independent manner could help understand the prognosis. Recent human and animal studies have shown that the relative abundance and the functional changes of microbiota in the stool, colonic mucosa and saliva have varying consequences on the presence and prognosis of chronic liver disease and cirrhosis. The impact of therapies on the microbiota is slowly being understood and will likely lead to a more targeted approach to gut microbiota modification in chronic liver disease and cirrhosis.

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Protective effect of omeprazole on gastric mucosal of cirrhotic portal hypertension rats

Abstract: Omeprazole has an important protective effect on gastric mucosal and it can increase gastric mucosal blood flow and related to many factors.

Cited by 15 publications

References 21 publications

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer

Establishment of a reversible model of prehepatic portal hypertension in rats

Gut microbiome and liver disease

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