Protective effect of Phyllanthus fraternus against cyclophosphamide-induced nephrotoxicity in rats

Abstract

Background: Cyclophosphamide is commonly used against malignancies, such as leukemia and solid organ cancers. It can induce nephrotoxicity in cancer patients thereby complicating the initiation of chemotherapy. The study is to evaluate the effect of Phylllanthus fraternus against cyclophosphamide induced nephrotoxicity in albino rats.Methods: In this study, a total of 20 albino rats were divided into four groups of five each. Group I (normal control) received i.p. injection of normal saline. While, group II, III and IV received single dose (200 mg/kg b/w) of cyclophosphamide i.p. on day 1. Group III and IV received 200 mg/kg and 400 mg/kg of aqueous extract of Phyllanthus fraternus respectively p.o. daily for 10 days. All the groups were fed with standard diet and water ad libitum. Serum levels of creatinine, urea and albumin were estimated. Histopathology of renal tissues was compared among the groups.Results: The renal parameters significantly improved in groups III and IV after 10 days of treatment with the extract. The histopathology study also supported the finding.Conclusions: The aqueous extract of Phyllanthus fraternus possesses protective effect against cyclophosphamide induced nephrotoxicity.

Protective Role of Aqueous Extract of Atriplex Halimus L. Against Benzene-Induced Damage on Renal Function and Glomerular Cells in Rats

“…The increased levels of urea and creatinine are considered as the marker of impaired kidney functions [27,28]. Thus, in our study, an increase of plasma urea and creatinine reflected the diagnosis of renal damage.…”

دراسة التأثير المحتمل لأوراق نبات القطف على حيوانات التجارب المصابة بارتفاع جلوکوز الدم

“…The finding of this study indicates that alloxan-induced diabetic in the rat at a dose (150 mg per kg) resulted in a significant increase serum liver enzymes (ALT and AST) and kidney functions (serum urea, uric acid and creatinine levels) compared with normal rats. Moirangthem et al, (36) reported that the increased levels of urea and creatinine are considered as the marker of impaired kidney functions. In this study, diabetic rats fed with 7.5% of A. halimus leaves powder treatment significantly (p<0.01) decreased the raised serum urea and creatinine, this means maintained healthy kidney function, and significantly restored the liver enzymatic activity compared with positive control.…”