Protective effect of pristane on experimental autoimmune uveitis

Daudin, J.-B.; Monnet, Dominique; Kavian, Niloufar; Espy, Cécile; Wang, Andrew; Chéreau, Christiane; Goulvestre, Claire; Omri, Samy; Brézin, Antoine P.; Weill, Bernard; Batteux, Frédéric; Nicco, Carole

doi:10.1016/j.imlet.2011.07.009

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…Rather, Treg cell-mediated uveitis control in mice was correlated with a decrease of ROS production in the eye, revealed by the level of myeloperoxidase and by ROS activity in infiltrating cells. ROS have been shown to be pathogenic in uveitis (27,28) by damaging endothelium cells and the retinal pigment epithelium, increasing the blood-retinal barrier permeability (28,54).…”

Section: Discussionmentioning

confidence: 99%

“…We then tested the role of ROS because these molecules are pathogenic in uveitis (27,28) and because one of the pleiotropic immunoregulatory effects of IL-10 is to reduce ROS production by myeloid cells (29)(30)(31). Administration of N-acetylcysteine, a ROS scavenger, led to a significant reduction of clinical signs of uveitis, compared with nontreated mice (Fig.…”

Section: In Situ Treg Cell Administration Induced a Decrease Of Ros Tmentioning

confidence: 99%

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Treatment of Uveitis by In Situ Administration of Ex Vivo–Activated Polyclonal Regulatory T Cells

Grégoire

Terrada

Martin

et al. 2016

The Journal of Immunology

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CD4+CD25+Foxp3+ regulatory T (Treg) cell therapy is a promising approach for the treatment of autoimmune diseases. To be effective, Treg cells should be in an activated state in the target tissue. This can be achieved by systemic administration of Ag-specific Treg cells, which are difficult to produce in conditions that can be translated to the clinic. In this paper, we propose an alternative approach consisting of in situ injection of preactivated polyclonal Treg cells that would exert bystander suppression in the target tissue. We show that polyclonal Treg cells suppressed uveitis in mice as efficiently as Ag-specific Treg cells but only when preactivated and administered in the vitreous. Uveitis control was correlated with an increase of IL-10 and a decrease of reactive oxygen species produced by immune cell infiltrates in the eye. Thus, our results reveal a new mechanism of Treg cell–mediated suppression and a new Treg cell therapy approach.

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Section: Discussionmentioning

confidence: 99%

Section: In Situ Treg Cell Administration Induced a Decrease Of Ros Tmentioning

confidence: 99%

Treatment of Uveitis by In Situ Administration of Ex Vivo–Activated Polyclonal Regulatory T Cells

Grégoire

Terrada

Martin

et al. 2016

The Journal of Immunology

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“…Pristane shows antiinflammatory activity and also has therapeutic uses in leishmania disese, human uveitis and diffuse pulmonary hemorrhage. 56,57 Dihydroactinidiolide or 5,6,7,7a-tetrahydro-4,4,7a-trimethyl-2(4H)-benzofuranone was present in EASE (0.53%). It is a monoterpenoid essential oil and it shows analgesic, antidiabetic, antibacterial and antifungal activities.…”

Section: Alcoholic and Phenolic Compoundsmentioning

confidence: 99%

Comparative GC-MS Analysis of Bioactive Phytochemicals from Different Plant Parts and Callus of Leptadenia reticulata Wight and Arn.

Godara¹,

Dulara²,

Barwer³

et al. 2019

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The aim of this study is identification and comparative analysis of bioactive phytochemicals present in methanol and ethyl acetate extracts of different plant organs and callus of Leptadenia reticulata by GC-MS technique. Methodology: The shade dried plant samples (leaves stem and root) and callus produced from leaf of L. reticulata were powdered and then sequentially extracted in methanol and ethyl acetate solvents. Total eight extracts were prepared which were Methanolic Leaf Extract (MLE), Methanolic Stem Extract (MSE), Methanolic Root Extract (MRE), Methanolic Callus Extract (MCE), Ethyl Acetate Leaf Extract (EALE), Ethyl Acetate Root Extract (EARE), Ethyl Acetate Stem Extract (EASE) and Ethyl Acetate Callus Extract (EACE). Then, each of the extracts was further subjected to Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Results: The GC-MS analysis of the eight extracts revealed the presence of 77 different types of high and low molecular weight phytochemicals and bioactive compounds in varying quantities. Some of the phytochemicals detected for first time in L. reticulata are γ-sitosterol, Campesterol, Pristane, Hexahydrofarnesol, Stearic acid, Arachidic acid, Coniferyl alcohol, n-Tetracosanol-1, Ascorbic acid 2,6-dihexadecanoate, (2S,3S)-3,7,4'-Trihydroxy-5-methoxy-6-methylflavanone etc. These chemical compounds are considered biologically active and pharmacologically important. Conclusion: This study gives a detailed comparison of detection and identification of various bioactive phytochemicals from different plant parts (leaves, stem and root) and callus of L. reticulata. This provides a basis for the biological and biochemical characterization of some newly detected biologically and pharmacologically important phytochemical components from this plant.

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“…A report demonstrated that NAC reduces the disease score and histopathology of IRBP-induced EAU in mice without details on the mechanism [46]. The same report also tested two kinds of structurally related mineral oils with pro-oxidative effects to treat EAU in mice.…”

Section: Discussionmentioning

confidence: 99%

Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice

Hsu

Yang

Teng

et al. 2020

IJMS

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Reactive oxygen species (ROS) are produced by host phagocytes and play an important role in antimicrobial actions against various pathogens. Autoimmune uveitis causes blindness and severe visual impairment in humans at all ages worldwide. However, the role of ROS in autoimmune uveitis remains unclear. We used ROS-deficient (Ncf1−/−) mice to investigate the role of ROS in experimental autoimmune uveitis (EAU). Besides, we also used the antioxidant N-acetylcysteine (NAC) treatment to evaluate the effect of suppression of ROS on EAU in mice. The EAU disease scores of Ncf1−/− mice were significantly lower than those of wild-type mice. EAU induction increased the levels of cytokines (interleukin (IL)-1α, IL-1β, IL-4, IL-6, IL-12, IL-17, and tumor necrosis factor (TNF)-α) and chemokines (monocyte chemoattractant protein (MCP)-1) in the retinas of wild-type mice but not in those of Ncf1−/− mice. EAU induction enhanced the level of NF-κB activity in wild-type mice. However, the level of NF-κB activity in Ncf1−/− mice with EAU induction was low. Treatment with the antioxidant NAC also decreased the severity of EAU in mice with reduced levels of oxidative stress, inflammatory mediators, and NF-κB activation in the retina. We successfully revealed a novel role of ROS in the pathogenesis of EAU and suggest a potential antioxidant role for the treatment of autoimmune uveitis in the future.

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Protective effect of pristane on experimental autoimmune uveitis

Cited by 8 publications

References 42 publications

Treatment of Uveitis by In Situ Administration of Ex Vivo–Activated Polyclonal Regulatory T Cells

Treatment of Uveitis by In Situ Administration of Ex Vivo–Activated Polyclonal Regulatory T Cells

Comparative GC-MS Analysis of Bioactive Phytochemicals from Different Plant Parts and Callus of Leptadenia reticulata Wight and Arn.

Suppression of the Reactive Oxygen Response Alleviates Experimental Autoimmune Uveitis in Mice

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