Protective effect of proteins derived from <i>Calotropis procera</i> latex against acute inflammation in rat

Kumar, Vijay; Guruprasad, B.; Chaudhary, Priyanka; Fatmi, Syed Meraj A.; Oliveira, Raquel Sombra Basílio de; Ramos, Márcio V.

doi:10.1111/aap.12022

Cited by 14 publications

(5 citation statements)

References 33 publications

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“…Most importantly the plant is used for their ant-leishmaniosis and antimalarial proprieties which are not well-known use for this species. It was shown that the latex of the plant is used as analgesic, anti-inflammatory, hepatoprotective, antidiarrhoeal, antidiabetic, antinociceptive, anthelmintic, anticonvulsant, antimicrobial, anticancer, antifertility, and antioxidant [101]. As well, W. somnifera is traditionally used in Jazan region mainly to expel intestinal worms and to cure several skin and urogenital diseases as well as for scorpion stings.…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical Study of Indigenous Medicinal Plants of Jazan Region, Saudi Arabia

Tounekti

Mahdhi

Khemira

2019

Evidence-Based Complementary and Alternative Medicine

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For a long time, the people of Saudi Arabia have been using medicinal plants (MPs) as conventional medicine to heal diverse human and livestock diseases. The present work is the first study on ethnobotanical uses of 124 MPs species used by the local tribal communities of Jazan province in the Southwest of Saudi Arabia. Ethnobotanical data were collected by interviewing 174 local informants using semistructured interviews. Informants of different ages, from several settlements belonging to several tribal communities, were interviewed. It is worth noticing that the age of informants and their knowledge of MPs were positively correlated, whereas the educational level and MP knowledge of participants were negatively correlated. To find out if there was agreement in the use of certain plants in the treatment of given ailments, we used Informant Consensus Factor (ICF). To determine the most frequently used plant species for treating a particular ailment category by local people we used the fidelity level (FL%). The Relative Frequency of Citation (RFC) was used to indicate the local importance of a species and the relative importance (RI) level was used to check the therapeutic potentials of the cited plants. A total of 124 MPs belonging to 103 genera and 48 families were collected and identified. The majority of these plants were shrubs (45%), perennial herbs (21%), annual herbs (19%), or trees (18%). The Asteraceae (10.48%), Fabaceae (7.25%), and Apocynaceae (7.25%) families were the most represented. Leaves, fruits, and whole plant (24%, 18%, and 16%, respectively) were the most used plant parts in formulating traditional medicines. Ziziphus spina-christi and Calotropis procera with the highest RI level (2.0) were found to have the highest range of therapeutic uses. They were followed by Datura stramonium (1.86), Withania somnifera, and Aloe vera (1.81). The ICF ranged from 0.02 to 0.42 covering 12 disease categories with a prevalence of disease categories related to skin and hair problems (ICF=0.42) having 75 species cited, while 73 species were cited for gastrointestinal tract (GIT) disorders (ICF = 0.40). Senna alexandrina (67%), Tribulus terrestris (64%), Pulicaria undulata (60%), Leptadenia pyrotechnica (55%), and Rumex nervosus (55%) had the highest FL which indicates their good healing potential against specific diseases. The high-FL species are the most promising candidate plants for in-depth pharmacological screening and merit further consideration. Accordingly, Jazan flora has good ethnobotanical potential. Unfortunately, many MP species are endangered by drought, overgrazing, and overexploitation. Some protection measures should be undertaken to prevent these species from becoming extinct. Natural reserves and wild nurseries are typical settings to retain medically important plants in their natural habitats, while botanic gardens and seed banks are important paradigms for ex situ conservation.

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Section: Resultsmentioning

confidence: 99%

Ethnobotanical Study of Indigenous Medicinal Plants of Jazan Region, Saudi Arabia

Tounekti

Mahdhi

Khemira

2019

Evidence-Based Complementary and Alternative Medicine

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“…However, the use of the plant in Mozambique for treatment of Tuberculoses (Jansen and Mendes, 1983) was not verified experimentally (Luo et al, 2011). In compliance with the TM uses the latex of Calotropis procera exhibited analgesic and anti-inflammatory effect against acute inflammation (Murti et al, 2015, Kumar et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

A survey on traditional plants used in Al Khobah village

Abdel‐Kader

Hazazi

Elmakki

et al. 2018

Saudi Pharmaceutical Journal

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The use of traditional medicine for treatment of various diseases is a common practise in most of the developing countries including the Kingdom of Saudi Arabia especially in rural areas. In this survey, Al Khobah village was selected to study the status of Traditional Medicine. Al Khobah village is located on the Southern boarders of the kingdom and characterized by diverse topography and moderate weather. The plants with medicinal uses were collected, identified and their methods of preparation and uses were recorded. After gathering all these information from the local people, literature survey was conducted on each plant to get information about pharmacological activities and weather they support the traditional use or not. The survey revealed that the uses of some plants are consistent with the experimental data in the literature. Some other plants were studied; however, they still need pharmacological investigation to prove the claimed uses. Other plant did not subject to any scientific investigation.

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“…The prednisolone and C. procera treatment significantly prevented the rise in nitrite level. One of the researchers reported that the treatment of non-dialyzable proteins of C. procera latex significantly decreases tissue level of nitrite [64].…”

Section: Discussionmentioning

confidence: 99%

Amelioration of complete Freund’s adjuvant-induced arthritis by Calotropis procera latex in rats

Patel¹,

Kadri

Gohil

et al. 2021

Futur J Pharm Sci

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Background Rheumatoid arthritis is the most common cause of disability, affecting 0.3–1% of the adult population worldwide. The latex of Calotropis procera possesses potent anti-inflammatory as well as analgesic properties. In light above facts, the present study was designed to evaluate anti-arthritic activity of Calotropis procera latex in complete Freund's adjuvant (CFA)-induced arthritis in Wistar albino rats. Complete Freund's adjuvant was injected into the left hind paw on day 0, and treatment of prednisolone and Calotropis procera latex was given from day 0 to 28. Various biochemical, hematological and functional parameters as well as radiological and histopathological changes of joint along with body weight and paw volume were measured. Results Calotropis procera treatment significantly lowered paw volume in CFA-induced arthritic rats. Significant improvement was observed in functional, biochemical and hematological parameters in Calotropis procera-treated rats. However, the body weight remained unaffected. Histological and radiographical examination of synovial joints in Calotropis procera-treated animals exhibited less synovial hyperplasia, infiltration and accumulation of inflammatory cell in synovial fluid, cartilage and bone erosion and joint space narrowing. Conclusion Calotropis procera latex possesses anti-arthritic activity, which is facilitated by modulation in the level of inflammatory mediators and oxidative stress. The improvement in hematological as well as biochemical parameters might be reflected on functional, histopathological, radiological changes and thereby disease progression.

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Protective effect of proteins derived from Calotropis procera latex against acute inflammation in rat

Cited by 14 publications

References 33 publications

Ethnobotanical Study of Indigenous Medicinal Plants of Jazan Region, Saudi Arabia

Ethnobotanical Study of Indigenous Medicinal Plants of Jazan Region, Saudi Arabia

A survey on traditional plants used in Al Khobah village

Amelioration of complete Freund’s adjuvant-induced arthritis by Calotropis procera latex in rats

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