Protective effect of quercetin against myocardial ischemia as a Ca2+ channel inhibitor: involvement of inhibiting contractility and Ca2+ influx via L-type Ca2+ channels

Liang, Yingran; Zhang, Yuanyuan; Liu, Miaomiao; Han, Xue; Zhang, Jianping; Zhang, Xuan; Chu, Li

doi:10.1007/s12272-020-01261-y

Cited by 24 publications

(16 citation statements)

References 48 publications

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“…This cardioprotective effect was also supported by a reduction of CK-MB and cardiac troponin T in quercetin-treated rats compared to the control group (152). Another in vivo study found that quercetin prevented inhibition of the sodium-potassium and the calcium pumps caused by myocardial infarction (149).…”

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 79%

“…This was further supported by lower levels of serum creatine kinase (CK), CK-MB, cardiac troponin T and lactate dehydrogenase, all enzymatic markers of myocardial insult (144,(147)(148)(149)(151)(152)(153)(154)(155). Histopathological examinations also revealed lower infiltration of leukocytes to the site of infarction, less edema and overall maintained tissue architecture (149,152,153). All these findings are in favor of a preservation of cardiomyocytes' membrane integrity and global improvement in myocardial function after exposure with quercetin.…”

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 94%

“…They showed that quercetin significantly slowed the decline in LVEF and fractional shortening compared with the control group (148). On macroscopic examination, treatment with quercetin induced a significant reduction of myocardial infarct size on triphenyl tetrazolium chloride (TTC) staining (149)(150)(151). This was further supported by lower levels of serum creatine kinase (CK), CK-MB, cardiac troponin T and lactate dehydrogenase, all enzymatic markers of myocardial insult (144,(147)(148)(149)(151)(152)(153)(154)(155).…”

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 99%

“…On macroscopic examination, treatment with quercetin induced a significant reduction of myocardial infarct size on triphenyl tetrazolium chloride (TTC) staining (149)(150)(151). This was further supported by lower levels of serum creatine kinase (CK), CK-MB, cardiac troponin T and lactate dehydrogenase, all enzymatic markers of myocardial insult (144,(147)(148)(149)(151)(152)(153)(154)(155). Histopathological examinations also revealed lower infiltration of leukocytes to the site of infarction, less edema and overall maintained tissue architecture (149,152,153).…”

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 99%

“…Lowered levels of CK, CK-MB, cTnT, and LDH post infarction(144,(147)(148)(149)(151)(152)(153)(154)(155) Decreased leukocytes' infiltration and edema in infarcted myocardium(149,152,153) (Continued)…”

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confidence: 99%

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Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Dagher

Mury

Thorin‐Trescases

et al. 2021

Front. Cardiovasc. Med.

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The vascular endothelium occupies a catalog of functions that contribute to the homeostasis of the cardiovascular system. It is a physically active barrier between circulating blood and tissue, a regulator of the vascular tone, a biochemical processor and a modulator of coagulation, inflammation, and immunity. Given these essential roles, it comes to no surprise that endothelial dysfunction is prodromal to chronic age-related diseases of the heart and arteries, globally termed cardiovascular diseases (CVD). An example would be ischemic heart disease (IHD), which is the main cause of death from CVD. We have made phenomenal advances in treating CVD, but the aging endothelium, as it senesces, always seems to out-run the benefits of medical and surgical therapies. Remarkably, many epidemiological studies have detected a correlation between a flavonoid-rich diet and a lower incidence of mortality from CVD. Quercetin, a member of the flavonoid class, is a natural compound ubiquitously found in various food sources such as fruits, vegetables, seeds, nuts, and wine. It has been reported to have a wide range of health promoting effects and has gained significant attention over the years. A growing body of evidence suggests quercetin could lower the risk of IHD by mitigating endothelial dysfunction and its risk factors, such as hypertension, atherosclerosis, accumulation of senescent endothelial cells, and endothelial-mesenchymal transition (EndoMT). In this review, we will explore these pathophysiological cascades and their interrelation with endothelial dysfunction. We will then present the scientific evidence to quercetin's anti-atherosclerotic, anti-hypertensive, senolytic, and anti-EndoMT effects. Finally, we will discuss the prospect for its clinical use in alleviating myocardial ischemic injuries in IHD.

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Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 79%

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 94%

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 99%

Section: Myocardial Protective Effects Of Quercetinmentioning

confidence: 99%

mentioning

confidence: 99%

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Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Dagher

Mury

Thorin‐Trescases

et al. 2021

Front. Cardiovasc. Med.

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Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca²⁺ homeostasis

Chen

et al. 2022

Phytotherapy Research

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Ischemia/hypoxia (I/H)-induced myocardial injury has a large burden worldwide. Hesperetin (HSP) has a cardioprotective effect, but the molecular mechanism underlying this is not clearly established. Here, we focused on the protective mechanisms of HSP against I/H-induced myocardium injury. H9c2 cardiomyocytes were challenged with CoCl 2 for 22 h to imitate hypoxia after treatment groups received HSP for 4 h. The viability of H9c2 cardiomyocytes was evaluated, and cardiac function indices, reactive oxygen species, apoptosis, mitochondrial membrane potential (MMP), and intracellular Ca 2+ concentration ([Ca 2+ ] i ) were measured. L-type Ca 2+ current (I Ca-L ), myocardial contraction, and Ca 2+ transients in isolated ventricular myocytes were also recorded. We found that HSP significantly increased the cell viability, and MMP while significantly decreasing cardiac impairment, oxidative stress, apoptosis, and [Ca 2+ ] i caused by CoCl 2 . Furthermore, HSP markedly attenuated I Ca-L , myocardial contraction, and Ca 2+ transients in a concentration-dependent manner.Our findings suggest a protective mechanism of HSP on I/H-induced myocardium injury by restoring oxidative balance, inhibiting apoptosis, improving mitochondrial function, and reducing Ca 2+ influx via L-type Ca 2+ channels (LTCCs). These data provide a new direction for HSP applied research as a LTCC inhibitor against I/H-induced myocardium injury.

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Is telomerase a hidden player? Therapeutic potential of natural telomerase activators against age-related diseases

2022

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Protective effect of quercetin against myocardial ischemia as a Ca2+ channel inhibitor: involvement of inhibiting contractility and Ca2+ influx via L-type Ca2+ channels

Cited by 24 publications

References 48 publications

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca²⁺ homeostasis

Is telomerase a hidden player? Therapeutic potential of natural telomerase activators against age-related diseases

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Protective effect of quercetin against myocardial ischemia as a Ca2+ channel inhibitor: involvement of inhibiting contractility and Ca2+ influx via L-type Ca2+ channels

Cited by 24 publications

References 48 publications

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Therapeutic Potential of Quercetin to Alleviate Endothelial Dysfunction in Age-Related Cardiovascular Diseases

Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca2+ homeostasis

Is telomerase a hidden player? Therapeutic potential of natural telomerase activators against age-related diseases

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Hesperetin ameliorates ischemia/hypoxia‐induced myocardium injury via inhibition of oxidative stress, apoptosis, and regulation of Ca²⁺ homeostasis