Protective Effect of Remote Ischemic Preconditioning in Renal Ischemia/Reperfusion Injury, in a Model of Thoracoabdominal Aorta Approach

Lazaris, Andreas; Maheras, Anastasios N.; Vasdekis, Spyros N.; Karkaletsis, Konstantinos G.; Charalambopoulos, A; Kakisis, John D.; Martikos, Georgios; Patapis, Paul; Giamarellos‐Bourboulis, Evangelos J.; Karatzas, Gabriel; Liakakos, Theodore

doi:10.1016/j.jss.2008.06.037

Cited by 36 publications

(24 citation statements)

References 50 publications

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“…The RIPC protocols limited the increase in MDA, thus indicating a possible protective effect against renal IRI (table 1). A narrow increase in serum MDA when RIPC precedes renal IRI has already been reported in the literature [27,32,42]. Similarly, RIPC has reduced the MDA levels, as compared to controls, in a rat model of spinal cord ischemia produced after a temporary aortic cross-clamping [43].…”

Section: Discussionmentioning

confidence: 68%

“…In our experience remote preconditioning has been successful by the temporary occlusion of the infrarenal aorta, although this involved different species [27]. This model of RIPC has been reported to be reliable in performance as well as being reproducible by different investigators.…”

Section: Discussionmentioning

confidence: 99%

“…In a previous experimental study, our group found a beneficial effect of RIPC against renal oxidative stress after supraceliac aortic temporary cross-clamping in rats [27]. Extending this model, in the current study we aimed to investigate the effect of RIPC in renal ischemia-reperfusion (IR) injury in an experimental setup of open thoracoabdominal aortic aneurysm repair in large mammals.…”

Section: Introductionmentioning

confidence: 99%

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Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping

Athanasiadis

Kapelouzou²,

Martikos³

et al. 2015

J Vasc Res

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Aim: The effect of remote ischemic preconditioning (RIPC) in decreasing renal ischemia-reperfusion injury (IRI) during a suprarenal aortic cross-clamping was examined in a swine model. Materials and Methods: Four groups of pigs were examined: (a) ischemia-reperfusion (IR) group, renal IRI produced by 30 min of supraceliac aortic cross-clamping; (b) RIPC I group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (15 min ischemia and 15 min reperfusion); (c) RIPC II group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (3 cycles of 5 min ischemia and 5 min reperfusion); (d) sham group. Renal function was assessed before and after IRI by examining creatinine, neutrophil gelatinase-associated lipocalin (NGAL), TNF-α, malondialdehyde (MDA), cystatin C and C-reactive protein (CRP) from renal vein blood samples at specific time intervals. Results: Both RIPC groups presented significantly less impaired results compared to the IR group when considering MDA, cystatin C, CRP and creatinine. Between the two RIPC groups, RIPC II presented a better response with regard to CRP, NGAL, TNF-α, MDA and cystatin C. Conclusions: Remote IR protocols and mainly repetitive short periods of cycles of IR ameliorate the biochemical kidney effects of IRI in a model of suprarenal aortic aneurysm repair.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping

Athanasiadis

Kapelouzou²,

Martikos³

et al. 2015

J Vasc Res

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“…The molecular mechanisms and effects of rIC, which have been investigated, include trigger factors [124,125], intracellular mediators/effectors [95,126,127] and anti-oxidative stress actions [17,111,128,129,130] to systemic and local anti-inflammatory effects [17,131,132] as well as an anti-fibrotic effect [68]. Four studies reported only functional endpoints [19,133,134,135].…”

Section: Mechanisms Of Renal Icmentioning

confidence: 99%

“…Improved renal function following rIPC, rIPerC and rIPoC has been associated with significantly higher levels of anti-oxidants (SOD, CAT, reduced GSH), decreased levels of MDA and higher levels of ferric reducing antioxidant power [17,111,128,129,130,137] (fig. 1).…”

Section: Mechanisms Of Renal Icmentioning

confidence: 99%

Molecular Mechanisms of Renal Ischemic Conditioning Strategies

et al. 2015

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Ischemia-reperfusion injury is the leading cause of acute kidney injury in a variety of clinical settings such as renal transplantation and hypovolemic and/or septic shock. Strategies to reduce ischemia-reperfusion injury are obviously clinically relevant. Ischemic conditioning is an inherent part of the renal defense mechanism against ischemia and can be triggered by short periods of intermittent ischemia and reperfusion. Understanding the signaling transduction pathways of renal ischemic conditioning can promote further clinical translation and pharmacological advancements in this era. This review summarizes research on the molecular mechanisms underlying both local and remote ischemic pre-, per- and postconditioning of the kidney. The different types of conditioning strategies in the kidney recruit similar powerful pro-survival mechanisms. Likewise, renal ischemic conditioning mobilizes many of the same protective signaling pathways as in other organs, but differences are recognized.

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Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: An emerging research perspective

Majumder

Singh

George

et al. 2018

J of Cellular Biochemistry

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Higher levels of nonprotein amino acid homocysteine (Hcy), that is, hyperhomocysteinemia (HHcy) (~5% of general population) has been associated with severe vasculopathies in different organs; however, precise molecular mechanism(s) as to how HHcy plays havoc with body’s vascular networks are largely unknown. Interventional modalities have not proven beneficial to counter multifactorial HHcy’s effects on the vascular system. An ancient Indian form of exercise called ‘yoga’ causes transient ischemia as a result of various body postures however the cellular mechanisms are not clear. We discuss a novel perspective wherein we argue that application of remote ischemic conditioning (RIC) could, in fact, deliver anticipated results to patients who are suffering from chronic vascular dysfunction due to HHcy. RIC is the mechanistic phenomenon whereby brief episodes of ischemia‐reperfusion events are applied to distant tissues/organs; that could potentially offer a powerful tool in mitigating chronic lethal ischemia in target organs during HHcy condition via simultaneous reduction of inflammation, oxidative and endoplasmic reticulum stress, extracellular matrix remodeling, fibrosis, and angiogenesis. We opine that during ischemic conditioning our organs cross talk by releasing cellular messengers in the form of exosomes containing messenger RNAs, circular RNAs, anti‐pyroptotic factors, protective cytokines like musclin, transcription factors, small molecules, anti‐inflammatory, antiapoptotic factors, antioxidants, and vasoactive gases. All these could help mobilize the bone marrow–derived stem cells (having tissue healing properties) to target organs. In that context, we argue that RIC could certainly play a savior’s role in an unfortunate ischemic or adverse event in people who have higher levels of the circulating Hcy in their systems.

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Protective Effect of Remote Ischemic Preconditioning in Renal Ischemia/Reperfusion Injury, in a Model of Thoracoabdominal Aorta Approach

Cited by 36 publications

References 50 publications

Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping

Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping

Molecular Mechanisms of Renal Ischemic Conditioning Strategies

Remote ischemic conditioning as a cytoprotective strategy in vasculopathies during hyperhomocysteinemia: An emerging research perspective

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