2019
DOI: 10.1002/jcb.29209
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Protective effect of RNA interference targeting Ikkβ on hepatic fibrosis in rats

Abstract: Nuclear factor‐κB (NF‐κB) is an important regulatory factor in cells. NF‐κB has a wide range of biological activities. After activation, it participates in the transcription and regulation of many genes and plays a role in infection, inflammatory response, oxidative stress, cell multiplication, and apoptosis. The activation of the NF‐κB signal pathway is dependent on the degradation of the IκB kinase β (IKKβ) complex. IKK β is the key kinase in the NF‐κB activation pathway. After inhibition, it can block the a… Show more

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