Protective Effect of Sasa Quelpaertensis and p-Coumaric Acid on Ethanol-induced Hepatotoxicity in Mice

S, Lee; An, Sang-Mi; Mun, Gyeong-In; Lee, Seung-Jin; Park, Kwon-Moo; Park, Sunhong; Boo, Yong Chool

doi:10.3839/jabc.2008.026

Cited by 17 publications

(9 citation statements)

References 22 publications

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“…In the present study, we examined whether SFN released from UVB-irradiated epidermal keratinocytes increases MMP1 release from dermal fibroblasts, and whether these events are affected by p-coumaric acid (p-CA), a natural metabolite produced in many plants such as Sasa quelpaertensis Nakai and Vaccinium bracteatum Thunberg [ 11 , 12 ]. p-CA was chosen as a test material because its UVB-shielding and anti-oxidant properties were previously demonstrated in cultured cells [ 13 , 14 ] and animal models [ 15 , 16 , 17 ]. The results from the current study showed that p-CA mitigated UVB-induced SFN expression in keratinocytes, and attenuated the MMP1 release by fibroblasts in medium transfer experiments, suggesting its utility as an active cosmetic ingredient.…”

Section: Introductionmentioning

confidence: 99%

p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts

Seok

Boo

2015

Korean J Physiol Pharmacol

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Ultraviolet (UV) radiation-induced loss of dermal extracellular matrix is associated with skin photoaging. Recent studies demonstrated that keratinocyte-releasable stratifin (SFN) plays a critical role in skin collagen metabolism by inducing matrix metalloproteinase 1 (MMP1) expression in target fibroblasts. In the present study, we examined whether SFN released from UVB-irradiated epidermal keratinocytes increases MMP1 release from dermal fibroblasts, and whether these events are affected by p-coumaric acid (p-CA), a natural phenolic compound with UVB-shielding and antioxidant properties. HaCaT cells were exposed to UVB in the absence and presence of p-CA, and the conditioned medium was used to stimulate fibroblasts in medium transfer experiments. The cells and media were analyzed to determine the expressions/releases of SFN and MMP1. UVB exposure increased SFN release from keratinocytes into the medium. The conditioned medium of UVB-irradiated keratinocytes increased MMP1 release from fibroblasts. The depletion of SFN using a siRNA rendered the conditioned medium of UVB-irradiated keratinocytes ineffective at stimulating fibroblasts to release MMP1. p-CA mitigated UVB-induced SFN expression in keratinocytes, and attenuated the MMP1 release by fibroblasts in medium transfer experiments. In conclusion, the present study demonstrated that the use of UV absorbers such as p-CA would reduce UV-induced SFN-centered signaling events involved in skin photoaging.

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Section: Introductionmentioning

confidence: 99%

p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts

Seok

Boo

2015

Korean J Physiol Pharmacol

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“…It has a potent antioxidant activity, which has been demonstrated in cultured cells [7] and animal models [8,9]. Recent studies including those of our laboratory have revealed attractive properties of PCA as a potential hypopigmenting agent.…”

Section: Introductionmentioning

confidence: 99%

UVB-Shielding Effects of para-Coumaric Acid

Song¹,

Boo²

2012

Journal of the Society of Cosmetic Scientists of Korea

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Recent studies have uncovered attractive properties of para-coumaric acid (PCA) as a potential skin hywhitening agent. The purpose of the current study was to examine its UVB-shielding effects. Effects of PCA on the viability of HaCaT cells exposed to UVB were assessed in vitro in comparison with other aromatic amino acid metabolites that have similar UV absorption spectra. For in vivo test, PCA cream (1.5 %) and cream base were topically applied to the dorsal skin of SKH-1 hairless mice and the inflammatory responses due to UVB exposure were monitored by changes in skin color (erythema) and thickness (edema). The cream application-UVB exposure regimen was repeated every other day for a total of 12 sessions. When HaCaT cells were irradiated with UVB, there was a dose-dependent decline in cell viability. The cell viability decline due to UVB exposure (10 mJ cm -2 ) was significantly prevented by 100 µM PCA, cinnamic acid, urocanic acid, or indole acrylic acid by 39, 27, 39, or 31 %, respectively. Topical application of PCA cream onto the dorsal skin of hairless mice (10 µg cm -2 ) attenuated the changes of color parameters, L*, a*, b* values, and thickness of the UVB (150 mJ cm -2 )-exposed skin by 59, 50, 58, and 53 %, respectively. The current study, together with the previous studies that demonstrated the antimelanogenic effects of PCA, suggested that PCA may prevent not only dyspigmentation but also inflammatory reactions in the UVB-exposed skin.

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“…Our previous report showed that an extract of which contained a considerable amount (23.7 mg/g) of p-coumaric acid, exerted anti-obesity effects via AMPK in mice fed a high-fat diet and 3T3-L1 cells. 7) Additionally, the extract and CA protected against ethanol-induced hepatotoxicity in mice, 8) their potential for modulating lipid metabolism in HepG2 cells has not been reported. In this study, we investigated to determine whether Jeju dwarf bamboo extract (JBE) and its main constituent, CA, activate AMPK and modulate lipid metabolism in HepG2 human hepatoma cells.…”

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confidence: 99%

Sasa quelpaertensisandp-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells

Kim

Kang

Shin

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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Protective Effect of Sasa Quelpaertensis and p-Coumaric Acid on Ethanol-induced Hepatotoxicity in Mice

Cited by 17 publications

References 22 publications

p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts

p-Coumaric Acid Attenuates UVB-Induced Release of Stratifin from Keratinocytes and Indirectly Regulates Matrix Metalloproteinase 1 Release from Fibroblasts

UVB-Shielding Effects of para-Coumaric Acid

Sasa quelpaertensisandp-Coumaric Acid Attenuate Oleic Acid-Induced Lipid Accumulation in HepG2 Cells

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